Validation of the MaGIC paediatric germ cell tumour risk stratification

Frazier, A. Lindsay; Faure‐Conter, Cécile; Fresneau, Brice; Lopes, Luiz Fernando; Pashankar, Farzana; Shaikh, Furqan; O’Neill, Amanda; Amatruda, J.F.; Krailo, Mark; Klosterkemper, L.; Piao, Jinhua; Xia, C.; Stoneham, Sara; Murray, Matthew J.; Nicholson, Jill

doi:10.1016/s1569-9056(19)32509-6

Cited by 4 publications

(3 citation statements)

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“…In the years since this protocol was first published, this risk stratification has been validated in three independent datasets, as provided by our Brazilian research group, together with the British and French clinical trial groups. The original MaGIC risk stratification method was confirmed, thus supporting its use in prospective clinical trial designs [53].…”

Section: Search For Better Therapeutic Approachesmentioning

confidence: 83%

Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review

Pinto

Martins

Vieira

et al. 2023

Cancers

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Ovarian germ cell tumors (OGCTs) are rare in adults; indeed, they occur predominantly in children, adolescents, and young adults, and they account for approximately 11% of cancer diagnoses in these groups. Because OGCTs are rare tumors, our current understanding of them is sparse; this is because few studies have investigated the molecular basis of pediatric and adult cancers. Here, we review the etiopathogenesis of OGCTs in children and adults, and we address the molecular landscape of these tumors, including integrated genomic analysis, microRNAs, DNA methylation, the molecular implications of treatment resistance, and the development of in vitro and in vivo models. An elucidation of potential molecular alterations may provide a novel field for understanding the pathogenesis, tumorigenesis, diagnostic markers, and genetic peculiarity of the rarity and complexity of OGCTs.

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Section: Search For Better Therapeutic Approachesmentioning

confidence: 83%

Molecular Biology of Pediatric and Adult Ovarian Germ Cell Tumors: A Review

Pinto

Martins

Vieira

et al. 2023

Cancers

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“…MAGIC analyzed patient data from both the COG and the Children's Cancer and Leukemia Group (UK), which resulted in the introduction of a further refined and validated risk stratification for children. [16][17][18] In contrast to the children or the adults, there is no universally accepted classification scheme for adolescents with a GCT. This remains a management challenge for this population.…”

Section: Stagingmentioning

confidence: 99%

“…Building on this work and others, the Malignant Germ Cell International Consortium (MAGIC) was formed in 2009. MAGIC analyzed patient data from both the COG and the Children's Cancer and Leukemia Group (UK), which resulted in the introduction of a further refined and validated risk stratification for children 16–18 . In contrast to the children or the adults, there is no universally accepted classification scheme for adolescents with a GCT.…”

Section: Stagingmentioning

confidence: 99%

Imaging of pediatric ovarian tumors: A COG Diagnostic Imaging Committee/SPR Oncology Committee White Paper

Behr

Morani

Artunduaga

et al. 2022

Pediatric Blood & Cancer

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Ovarian tumors in children are uncommon. Like those arising in the adult population, they may be broadly divided into germ cell, sex cord, and surface epithelium subtypes; however, germ cell tumors comprise the majority of lesions in children, whereas tumors of surface epithelial origin predominate in adults. Diagnostic workup, including the use of imaging, requires an approach that often differs from that required in an adult. This paper offers consensus recommendations for imaging of pediatric patients with a known or suspected primary ovarian malignancy at diagnosis and during follow‐up.

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