Validation of SinoSCORE for isolated CABG operation in East China

Ma, Xiue; Wang, Yunqian; Shan, Lingtong; Cang, Zheng-Qiang; Gu, Chang; Qu, Nianyi; Li, Qifan; Li, Jun; Wang, Zhenhua; Zhang, Yangyang

doi:10.1038/s41598-017-16925-x

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…The post hoc pairwise comparison was conducted with Fisher's least significant difference t -test, expression at multiple time points was analyzed with repeated measurement ANOVA (denoted by F ), and the post hoc test was carried out with Bonferroni [ 20 , 21 ]. The diagnostic value of miR-29c-3p and CDCA4 in MM was visualized with a receiver operating characteristic (ROC) curve [ 22 ]. Pearson's test identified the correlation of miR-29c-3p with CDCA4 in the serum, and the Cox analysis analyzed the independent prognostic factors of MM.…”

Section: Methodsmentioning

confidence: 99%

Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression

Liu

Tao

Zhong

et al. 2021

BioMed Research International

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Objective. To investigate the expression and regulation mechanism of miR-29c-3p and cell division cycle associated 4 (CDCA4) in melanoma (MM). Data and Methods. Fifty-nine patients with MM admitted to our hospital were enrolled as the MM group. They were followed up for 3 years to analyze the prognostic factors; meanwhile, 51 healthy subjects were allocated into a normal group. MM cell lines (M21 and C8161) were transfected with miR-29c-3p-mimics, miR-29c-3p-inhibitor, miR-NC, si-CDCA4, and sh-CDCA4. The expression of miR-29c-3p, CDCA4, Bax, Caspase3, Bcl-2, N-cadherin, vimentin, and E-cadherin was quantified, and cell proliferation, migration, invasion, and apoptosis, as well as epithelial-mesenchymal transition (EMT), were determined. Results. Serum miR-29c-3p was lowly expressed and CDCA4 was highly expressed in the MM group. The area under the curve (AUC) of both for diagnosing MM was greater than 0.9. miR-29c-3p and CDCA4 were related to regional lymph node staging (N staging), distant metastasis (M staging), tumor diameter, and pathological differentiation. Low miR-29c-3p and high CDCA4 were associated with poor prognosis of MM. Overexpression of miR-29c-3p and suppression of CDCA4 hindered cell proliferation, migration, invasion, and expression of Bax, Caspase3, N-cadherin, and vimentin, but cell apoptosis and expression of Bcl-2 and E-cadherin were enhanced. Dual-luciferase reporter (DLR) assay confirmed the targeted relationship between miR-29c-3p and CDCA4. After miR-29c-3p-mimics+sh-CDCA4 was transfected into M21 and C8161 cells, the proliferation, invasion, and apoptosis were not different from those in the miR-NC group transfected with unrelated sequences. Conclusion. Overexpression of miR-29c-3p suppresses CDCA4 expression and decreases proliferation, migration, invasion, apoptosis, and EMT of MM cells, thus hindering MM progression.

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Section: Methodsmentioning

confidence: 99%

Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression

Liu

Tao

Zhong

et al. 2021

BioMed Research International

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“…The performance of the EuroSCORE II was poor among patients with the lower predicted mortality [ 20 ]. Moreover, our previous research considered that EuroSCORE II underestimated the risk of cardiac surgery for the Chinese population, especially for CABG patients [ 21 , 22 ]. Continuing to use the model may mislead the judgment of clinicians and even will harm the interest of patients.…”

Section: Discussionmentioning

confidence: 99%

Predictive ability of EuroSCORE II integrating cardiactroponin T in patients undergoing OPCABG

Shan

et al. 2020

BMC Cardiovasc Disord

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Background Preoperative risk evaluation systems are significant and important to the allocation of medical resources and the communication between doctors and patients. The European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) is widely used in clinical practice. Cardiac troponin T (cTnT) can specifically and accurately reflect myocardial injury. Whether EuroSCORE II can improve the predictive power after integrating with cTnT is still unclear. This study was a retrospective single center study designed to assess the predictive ability of EuroSCORE II integrated with cTnT for patients undergoing isolated off-pump coronary artery bypass grafting (OPCABG). Methods This retrospective and observational cohort study included 1887 patients who underwent first isolated OPCABG. cTnT was detected within 48 h before operation in each patient. According to myocardial injury, patients were divided by cTnT into 4 stages. A new risk evaluation system was created through logistic regression with EuroSCORE II and myocardial injury classification as covariates. Then the two risk evaluation systems were comparatively assessed by regression analysis, receiver operator characteristic curves, net reclassification index, Bland–Altman plots and decision curve analysis. Results There were 43 in-hospital deaths, with a mortality of 2.30% (43/1887). The logistic regression analysis showed that preoperative myocardial injury classification was a significant risk factor for in-hospital mortality in both total cohort (OR 1.491, 95%CI 1.049–2.119) and subsets (OR 1.761, 95%CI 1.102–2.814). The new risk evaluation system has higher calibration and discrimination power than EuroSCORE II, both for overall cohort and subsets. Especially, the new system has obvious advantages in discrimination power in the subset of acute myocardial infarction (AUC 0.813 vs. 0.772, 0.906 vs. 0.841, and 0.715 vs. 0.646, respectively). Conclusions Both myocardial injury classification and EuroSCORE II are independent risk factors of in-hospital mortality in OPCABG patients. The new risk evaluation system has higher predictive ability than EuroSCORE II, especially in patients with a recent history of AMI.

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“…The meta-analysis by Guida et al 3 , which included 22 studies, showed overall discrimination of 0.79, similar to that in our study. The most recent publications, not included yet in a systematic review, include some of the following: Iran 21 , China 22,23 , Greece 24 , Spain 25,26 , India 27 , US 28,29 , and the Netherlands 30 , with ROC areas ranging from 0.67 to 0.87.…”

Section: Discussionmentioning

confidence: 99%

Multicenter prospective validation of the European System for Cardiac Operative Risk Evaluation II in Argentina

Borracci¹,

Rubio²,

Baldi-Jr³

et al. 2020

ACME

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Objective: To validate prospectively in multiple centers, the accuracy and clinical utility of the European System for Cardiac Operative Risk Evaluation (EuroSCORE II) to predict the operative mortality of cardiac surgery in Argentina. Methods: Between January 2012 and February 2018, 2000 consecutive adult patients who underwent cardiac surgery in different centers in Argentina were prospectively included. The endpoint was in-hospital all-cause mortality. Discrimination, calibration, precision, and clinical utility of the EuroSCORE II were evaluated in the global cohort and in the different types of surgeries, based on receiver operating characteristics (ROC) curves, Hosmer-Lemeshow goodness-of-fit test, observed/expected mortality ratio, Shannon index, and decision curves analysis. Results: ROC area of the EuroSCORE II was between 0.73 and 0.80 for all types of surgery, being the lowest value for coronary surgery. The observed and expected mortality was 4.3% and 3.0%, respectively (p = 0.034). The decision curve analysis showed a positive net benefit for all thresholds below 0.24, considering all type of surgeries. Conclusions: The EuroSCORE II showed an adequate performance in terms of discrimination and calibration for all types of surgery, although somewhat inferior for coronary surgery. Although, in general terms, this model underestimated the risk in intermediate-risk groups, its overall performance was acceptable. The EuroSCORE II could be considered an optional updated generic model of operative risk stratification to predict in-hospital mortality after cardiac surgery in our context.

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Validation of SinoSCORE for isolated CABG operation in East China

Cited by 13 publications

References 26 publications

Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression

Upregulation of miR-29c-3p Hinders Melanoma Progression by Inhibiting CDCA4 Expression

Predictive ability of EuroSCORE II integrating cardiactroponin T in patients undergoing OPCABG

Multicenter prospective validation of the European System for Cardiac Operative Risk Evaluation II in Argentina

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