Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients

Höll, G.; Dorn, R.; Wengenmair, H.; Weckermann, Dorothea; Sciuk, J.

doi:10.1007/s00259-009-1157-2

Cited by 126 publications

(186 citation statements)

References 19 publications

Supporting

Mentioning

169

Contrasting

Unclassified

Order By: Relevance

“…Another intraoperative sampling technique, sentinel node surgery, has only recently been used in prostate pathology, and is usually used in a research setting. 39 Staging of prostate cancer may be improved through the recovery of greater numbers of lymph nodes for examination purposes. 40 Xylene and other clearance techniques have been used by some to increase lymph node retrieval.…”

Section: Lymph Node Macroscopic Assessmentmentioning

confidence: 99%

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes

et al. 2011

View full text Add to dashboard Cite

The 2009 International Society of Urological Pathology Consensus Conference in Boston made recommendations regarding the standardization of pathology reporting of radical prostatectomy specimens. Issues relating to the infiltration of tumor into the seminal vesicles and regional lymph nodes were coordinated by working group 4. There was a consensus that complete blocking of the seminal vesicles was not necessary, although sampling of the junction of the seminal vesicles and prostate was mandatory. There was consensus that sampling of the vas deferens margins was not obligatory. There was also consensus that muscular wall invasion of the extraprostatic seminal vesicle only should be regarded as seminal vesicle invasion. Categorization into types of seminal vesicle spread was agreed by consensus to be not necessary. For examination of lymph nodes, there was consensus that special techniques such as frozen sectioning were of use only in high-risk cases. There was no consensus on the optimal sampling method for pelvic lymph node dissection specimens, although there was consensus that all lymph nodes should be completely blocked as a minimum. There was also a consensus that a count of the number of lymph nodes harvested should be attempted. In view of recent evidence, there was consensus that the diameter of the largest lymph node metastasis should be measured. These consensus decisions will hopefully clarify the difficult areas of

show abstract

Section: Lymph Node Macroscopic Assessmentmentioning

confidence: 99%

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes

et al. 2011

View full text Add to dashboard Cite

show abstract

“…The detection rate of the SN procedure ranged 76-100%. 5,8,9,12,23,25,29,31,33,36,[43][44][45][46][47][48] A total of 13-75% of the patients showed one or more SN outside the limited PLND template. In addition, SN were detected outside the standard PLND in 51.8-76.9% of the patients with positive LN.…”

Section: Clinical Implications Of Sn Biopsy For Pcamentioning

confidence: 99%

“…In 4.1-25% of patients, SN outside the ePLND template were found, whereas 3.5-17% of patients with positive LN had SN metastases outside the ePLND template. 5,7,8,[23][24][25]27,28,31,33,37,[43][44][45]47,[49][50][51][52][53][54] In these studies, the median percentage of positive LN was 20.4% (range 4.7-50) with a FN rate of 1% (range 0-20), respectively.…”

Section: Clinical Implications Of Sn Biopsy For Pcamentioning

confidence: 99%

See 1 more Smart Citation

Advances in sentinel node dissection in prostate cancer from a technical perspective

et al. 2015

View full text Add to dashboard Cite

Abbreviations & Acronyms ePLND = extended pelvic lymph node dissection FN = false negative ICG = indocyanine green LN = lymph node MRI = magnetic resonance imaging NIR = near-infrared NR = not reported PCa = prostate cancer PET = positron emission tomography PLND = pelvic lymph node dissection SN = sentinel node SPECT-CT = single-photon emission computed tomography combined with computed tomography TRUS = transrectal ultrasound Abstract: The most important feature of sentinel node biopsy for prostate cancer procedure is that staging can be improved. Sentinel nodes might be found outside the extended pelvic lymph node dissection template what renders the sentinel node additive of extended pelvic lymph node dissection. At the same time, staging within the template can be further refined. We reviewed the literature regarding the sentinel node biopsy procedure for prostate cancer. PubMed and Embase were searched for all Englishlanguage publications from January 1999 to September 2014 by using the keywords as "prostate cancer" and "sentinel lymph node" plus "biopsy" "dissection" and/or "procedure." The present review discusses step-by-step sentinel node biopsy for prostate cancer. Topics of discussion are: (i) preoperative sentinel node mapping (tracers and imaging); (ii) intraoperative sentinel node identification (surgical procedure and outcome); and (iii) novelties to improve sentinel node identification (pre-and intraoperative approaches). Conventional sentinel node mapping is carried out after the injection of a 99m Tc-based tracer and subsequent preoperative imaging; for example, lymphoscintigraphy and singlephoton emission computed tomography/computed tomography. This approach allowed the detection of sentinel nodes outside the extended lymph node dissection template in 3.6-36% of men with intermediate-and high-risk prostate cancer. Hereby, an overall false negative rate of sentinel nodes was reported between 0% and 24.4%. To further refine the intraoperative sampling procedure, novel imaging methods such as fluorescence imaging have been introduced. Prospective randomized comparison studies are required to confirm the added benefit of sentinel template directed nodal dissection. A proper and obtainable end-point of such a study could be the number of removed positive nodes for carrying out nodal dissection with or without sentinel template directed dissection. Similarly, the clinical impact of novel imaging technologies requires further investigation.

show abstract

“…N staging directly influences the treatment decision in patients for whom potentially curative treatments are planned. However, the authors [1] provide a reminder that there is an ongoing debate about which patients require lymph node resection and how the dissection should be extended [2]. The Augsburg group first developed and described sentinel lymphadenectomy (SLNE) in prostate cancer.…”

mentioning

confidence: 99%

Commentary on: Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients

Brenot-Rossi

Bastide

2009

Eur J Nucl Med Mol Imaging

View full text Add to dashboard Cite

Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients

Abstract: Our results demonstrate that SLND in prostate cancer is a reliable procedure for nodal staging.

Cited by 126 publications

References 19 publications

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes

International Society of Urological Pathology (ISUP) Consensus Conference on Handling and Staging of Radical Prostatectomy Specimens. Working group 4: seminal vesicles and lymph nodes

Advances in sentinel node dissection in prostate cancer from a technical perspective

Commentary on: Validation of sentinel lymph node dissection in prostate cancer: experience in more than 2,000 patients

Contact Info

Product

Resources

About