Validation of proteomic biomarkers previously found to be differentially expressed in women with Polycystic Ovary Syndrome: a cross-sectional study

Abstract

Total haptoglobin and haptoglobin beta chain protein abundance was found to be elevated in women with PCOS compared with controls. We were unable to confirm decreased alpha-2 macroglobulin levels as reported in a previous study. Independent validation studies are required to validate early promising proteomic biomarkers in PCOS.

Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome

“…This finding supports previous proteomic studies suggesting that Hp may be a biomarker of PCOS [16,17]. In addition, a small study in the UK (n = 30 per group) using Western blotting to quantify Hp protein subunits found that total Hp and Hp beta chain protein abundance were elevated in women with PCOS compared with controls [54].…”

Regulatory and transport proteins in the serum and follicular fluid of patients with polycystic ovary syndrome and in tubal factor infertility in predicting the effectiveness offertilization programs

“…Результаты проведенного исследования не подтверждают мнения некоторых авторов [13,18,26,27] о том, что развитие СПКЯ сопряжено с признаками хронического воспаления низкой степени выраженности. Мы полагаем, что повышенные сывороточные концентрации α 2 -МГ и α 1 -АТ могут быть связаны с нарушением утилизации клетками, так как у большинства женщин поликистоз яичников ассоциируется с ожирением, что может свидетельствовать о снижении эффективности работы гепатоцитов.…”

Polycystic ovary syndrome and iron overload: biochemical link and underlying mechanisms with potential novel therapeutic avenues

“…Thus, the decrease in the circulating levels of hepcidin as well as α2-macroglobulin in patients with PCOS produces a synergistic effect in increasing the density of the iron exporter ferroportin in the cell surface of duodenal enterocytes and macrophages, leading to an increase in circulating levels of iron. However, a later study could not confirm the decrease in circulating levels of α2-macroglobulin in PCOS patients [ 40 ], thus underlining the need for additional studies in this area.…”