Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome

Carvalho, Laura Machado Lara; Ferreira, Cláudia N.; Oliveira, Daisy K. D. de; Rodrigues, Kathryna Fontana; Duarte, Rita Carolina Figueiredo; Teixeira, Márcia F. A.; Xavier, Luana B.; Cândido, Alexandre Luna; Reis, Fernando M.; Silva, Ieda F. O.; Campos, Fernanda Magalhães Freire; Gomes, Karina Braga

doi:10.1007/s10815-017-1030-3

Cited by 16 publications

(17 citation statements)

References 52 publications

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“…Proteomic studies have suggested that haptoglobin -an inflammatory acute phase glycoprotein -may be also associated to PCOS (Matharoo-Ball et al 2007;Insenser et al 2010). More recently, we conducted a case-control study (Carvalho et al 2017b) that showed higher plasma haptoglobin levels in the PCOS group than in controls. In the aforementioned study, haptoglobin also showed a positive correlation with C-reactive protein (CRP) and pro-oxidative profile in the PCOS group.…”

Section: Pathophysiology Of Pcosmentioning

confidence: 86%

“…There is an imbalance in PCOS between pro-inflammatory mediators and anti-inflammatory cytokines, which is associated with a systemic low-grade inflammation in these women (Duleba and Dokras 2012;Mortada et al 2015;Soter et al 2015;Aytan et al 2016). Inflammation is considered to be a strong link between the numerous metabolic ramifications of the syndrome, such as IR, dyslipidemia, and T2DM (Repaci et al 2011), and may also contribute to an increased risk of cardiovascular complications in PCOS (Repaci et al 2011;Soter et al 2015;Carvalho et al 2017b).…”

Section: Pathophysiology Of Pcosmentioning

confidence: 99%

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Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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Polycystic Ovary Syndrome (PCOS) is characterized by hyperandrogenism, amenorrhea, and polycystic ovaries. This endocrinopathy is associated with many metabolic disorders such as dyslipidemia and insulin resistance, with increased risk of type 2 diabetes mellitus, metabolic syndrome, and cardiovascular complications. Inflammation is likely to play an important role in the promoting these metabolic imbalances, while prothrombotic and pro-oxidative mechanisms further contribute to the cardiovascular risk of these patients. The etiology of PCOS is still not fully understood, but there is evidence of genetic and environmental components. This review aims to discuss some molecular pathways associated with PCOS that could contribute to the better understanding about this syndrome. Recent evidence suggests that intrauterine exposure of female mice to an excess of anti-Müllerian hormone may induce PCOS features in their post-natal life. High cytokine levels and cytokine gene polymorphisms also appear to be associated with the pathophysiology of PCOS. Furthermore, high levels of microparticles may contribute to the altered hemostasis and enhanced inflammation in PCOS. All these mechanisms may be relevant to clarify some aspects of PCOS pathogenesis and inspire new strategies to prevent the syndrome as well as treat its symptoms and mitigate the risk of long-term complications.

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Section: Pathophysiology Of Pcosmentioning

confidence: 86%

Section: Pathophysiology Of Pcosmentioning

confidence: 99%

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Carvalho

Reis

Cândido

et al. 2018

Endocrine Regulations

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“…Dyslipidemia is the most common metabolic disorder in PCOS patients [42]. It has a prevalence rate of 70% and is positively correlated with IR [43]. IR reduces ability of the insulin to inhibit lipase, leading to a high level of free fatty acids and an increase in the risk of obesity and cardiovascular diseases in PCOS patients.…”

Section: Ir and The Metabolic Abnormality In Women With Pcosmentioning

confidence: 99%

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

2020

J Ovarian Res

159

132

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Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder. Typically, it is characterized by hirsutism, hyperandrogenism, ovulatory dysfunction, menstrual disorders and infertility. To date, its pathogenesis remains unclear. However, insulin resistance (IR) is considered as the primary pathological basis for its reproductive dysfunction. On the other hand, a condition in which insulin is over-secreted is called hyperinsulinemia. IR/ Hyperinsulinemia is associated with chronic inflammation, hormonal changes, follicular dysplasia, endometrial receptivity changes, and abortion or infertility. Additionally, it increases incidence of complications during pregnancy and has been associated with anxiety, depression, and other psychological disorders. Gut microbiota, the "second genome" acquired by the human body, can promote metabolism, immune response through interaction with the external environment. Gut microbiota dysbiosis can cause IR, which is closely linked to the occurrence of PCOS. This article reviewed recent findings on the roles of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome.

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“…Table 1 summarizes the characteristics of studies on Brazilian populations. Seven studies were from the Northeast region [23][24][25][26][27][28][29], thirteen studies were from the Southeast [30][31][32][33][34][35][36][37][38][39][40][41][42], five studies were from the South [43][44][45][46][47], and two studies were from the Midwest region [48,49]. No data from the North region were available.…”

Section: Discussionmentioning

confidence: 99%

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Spritzer

Ramos

Marchesan

et al. 2021

Diabetol Metab Syndr

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Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries.

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Haptoglobin levels, but not Hp1-Hp2 polymorphism, are associated with polycystic ovary syndrome

Abstract: Hp1-Hp2 polymorphism is not associated with PCOS but plasma Hp could be a potential biomarker for PCOS and its complications.

Cited by 16 publications

References 52 publications

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Polycystic Ovary Syndrome as a systemic disease with multiple molecular pathways: a narrative review

Role of gut microbiota in the development of insulin resistance and the mechanism underlying polycystic ovary syndrome: a review

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

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