Validation of Predictive Metabolic Syndrome Biomarkers of World Trade Center Lung Injury

Kwon, Sophia; Crowley, George; Caraher, Erin J.; Haider, Syed Hissam; Lam, Rachel; Veerappan, Arul; Yang, Lei; Liu, Mengling; Zeig‐Owens, Rachel; Schwartz, Theresa; Prezant, David J.; Nolan, Anna

doi:10.1016/j.chest.2019.02.019

Cited by 21 publications

(50 citation statements)

References 72 publications

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“…Our study shows that a single exposure of WTC-PM is associated with acute and chronic cardiopulmonary changes. WTC-PM exposure has traditionally been known to cause pulmonary disease [7][8][9] . We demonstrate that there are early vascular and hemodynamic changes, evidence of hypermetabolic activity, collagen deposition, and oxidative stress following WTC-PM exposure.…”

Section: Discussionmentioning

confidence: 99%

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model

Veerappan

Oskuei

Crowley

et al. 2020

Sci Rep

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Vascular changes occur early in the development of obstructive airways disease. However, the vascular remodeling and dysfunction due to World trade center-particulate Matter (Wtc-pM) exposure are not well described and are therefore the focus of this investigation. C57Bl/6 female mice oropharyngeally aspirated 200 µg of Wtc-pM 53 or phosphate-buffered saline (PBS) (controls). 24-hours (24-hrs) and 1-Month (1-M) after exposure, echocardiography, micro-positron emission tomography(µ-pet), collagen quantification, lung metabolomics, assessment of antioxidant potential and soluble-receptor for advanced glycation end products (sRAGE) in bronchoalveolar lavage(BAL) and plasma were performed. 24-hrs post-exposure, there was a significant reduction in (1) Pulmonary artery(PA) flowvelocity and pulmonary ejection time(PET) (2) Pulmonary acceleration time(PAT) and PAT/PET, while (3) Aortic ejection time(AET) and velocity time integral(VTI) were increased, and (4) Aortic acceleration time (AAT)/AET, cardiac output and stroke volume were decreased compared to controls. 1-M postexposure, there was also significant reduction of right ventricular diameter as right ventricle free wall thickness was increased and an increase in tricuspid E, A peaks and an elevated E/A. The pulmonary and cardiac standard uptake value and volume 1-M post-exposure was significantly elevated after pM-exposure. Similarly, α-smooth muscle actin(α-SMA) expression, aortic collagen deposition was elevated 1-M after PM exposure. In assessment of the metabolome, prominent subpathways included advanced glycation end products (AGEs), phosphatidylcholines, sphingolipids, saturated/ unsaturated fatty acids, eicosanoids, and phospholipids. BAL superoxide dismutase(SOD), plasma total-antioxidant capacity activity, and sRAGE (BAL and plasma) were elevated after 24-hrs. PM exposure and associated vascular disease are a global health burden. our study shows persistent Wtc-Cardiorespiratory and Vascular Dysfunction (WTC-CaRVD), inflammatory changes and attenuation of antioxidant potential after pM exposure. early detection of vascular disease is crucial to preventing cardiovascular deaths and future work will focus on further identification of bioactive therapeutic targets. The negative health effects of particulate matter (PM) exposure are a significant global burden. Epidemiologic studies demonstrate associations between PM exposure and development of lung and cardiovascular disease(CVD) 1,2. Pulmonary vascular remodeling occurs in mild non-hypoxemic chronic obstructive pulmonary

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Section: Discussionmentioning

confidence: 99%

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model

Veerappan

Oskuei

Crowley

et al. 2020

Sci Rep

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“…(12)(13)(14)(15)(16)(17)(18)(19) Furthermore, metabolic biomarkers, elevated BMI, and a >2 kg/m 2 BMI increase predicted WTC-OAD. (15,(20)(21)(22)(23) Since high-caloric diets are key contributors to MetSyn, nutritional interventions to potentially reverse pulmonary dysfunction have been studied. (14)(15)(16) Our in vitro and in vivo models identi ed that the receptor for AGE(RAGE) is associated with lung dysfunction after WTC-particulate matter (WTC-PM) exposure.…”

Section: Introductionmentioning

confidence: 99%

“…(9)(10)(11) Speci cally, Mediterranean diets characterized by high consumption of fruits, vegetables, and sh, were associated with lower COPD, whereas, western diets were signi cantly associated with higher risk of newly diagnosed COPD. (12)(13)(14)(15)(16) Metabolic syndrome (MetSyn) is a risk factor of cardiovascular, lung disease, and World Trade Center-OAD (WTC-OAD). (15,16) It affects over 30% of US adults and 23% of participants in the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) program.…”

Section: Introductionmentioning

confidence: 99%

“…(12)(13)(14)(15)(16) Metabolic syndrome (MetSyn) is a risk factor of cardiovascular, lung disease, and World Trade Center-OAD (WTC-OAD). (15,16) It affects over 30% of US adults and 23% of participants in the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) program. (12)(13)(14)(15)(16)(17)(18)(19) Furthermore, metabolic biomarkers, elevated BMI, and a >2 kg/m 2 BMI increase predicted WTC-OAD.…”

Section: Introductionmentioning

confidence: 99%

“…(15,16) It affects over 30% of US adults and 23% of participants in the Fire Department of New York (FDNY) WTC-Health Program (WTC-HP) program. (12)(13)(14)(15)(16)(17)(18)(19) Furthermore, metabolic biomarkers, elevated BMI, and a >2 kg/m 2 BMI increase predicted WTC-OAD. (15,(20)(21)(22)(23) Since high-caloric diets are key contributors to MetSyn, nutritional interventions to potentially reverse pulmonary dysfunction have been studied.…”

Section: Introductionmentioning

confidence: 99%

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Dietary Phenotype and Advanced Glycation End-Products Predict WTC-Obstructive Airways Disease: a Longitudinal Observational Study

Lam

Kwon

Riggs

et al. 2020

Preprint

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BACKGROUND. Diet is a modifier of metabolic syndrome which in turn is associated with World Trade Center Obstructive Airways Disease(WTC-OAD). We have designed this study to 1.assess the dietary phenotype(food types, physical activity, and dietary habits) of the Fire Department of New York(FDNY) WTC-Health Program(WTC-HP) cohort and 2.quantify the association of dietary quality and its advanced glycation end product(AGE) content with the development of WTC-OAD.METHODS. WTC-OAD, defined as developing WTC-Lung Injury(WTC-LI;FEV1<LLN) and/or airway hyperreactivity(AHR;positive methacholine and/or positive bronchodilator response). Rapid Eating and Activity Assessment for Participants-Short Version(REAP-S) deployed on 3/1/2018 in the WTC-HP annual monitoring assessment. Clinical and REAP-S data of consented subjects was extracted(7/17/2019). Diet quality[low-(15-19), moderate-(20-29), and high-(30-39)] and AGE content per REAP-S questionnaire were assessed for association with WTC-OAD. Regression models adjusted for smoking,hyperglycemia,hypertension,age on 9/11,WTC-exposure,BMI and job description. RESULTS. N=9,508 completed the annual questionnaire, while N=4,015 completed REAP-S and had spirometry. WTC-OAD developed in N=921, while N=3,094 never developed WTC-OAD. Low- and moderate-dietary quality, eating more (processed meats,fried foods,sugary drinks), fewer(vegetables,whole-grains),and having a diet abundant in AGEs were significantly associated with WTC-OAD. Smoking was not a significant risk factor of WTC-OAD. CONCLUSIONS. REAP-S was successfully implemented in the FDNY WTC-HP monitoring questionnaire and produced valuable dietary phenotyping. Our observational study has identified low dietary quality and AGE abundant dietary habits as risk factors for pulmonary disease in the context of WTC-exposure. Dietary phenotyping, not only focuses our metabolomic/biomarker profiling but also further informs future dietary interventions that may positively impact particulate matter associated lung disease.

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Twenty-Year Reflection on the Impact of World Trade Center Exposure on Pulmonary Outcomes in Fire Department of the City of New York (FDNY) Rescue and Recovery Workers

Cleven

Rosenzvit

Nolan

et al. 2021

Lung

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Validation of Predictive Metabolic Syndrome Biomarkers of World Trade Center Lung Injury

Cited by 21 publications

References 72 publications

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model

World Trade Center-Cardiorespiratory and Vascular Dysfunction: Assessing the Phenotype and Metabolome of a Murine Particulate Matter Exposure Model

Dietary Phenotype and Advanced Glycation End-Products Predict WTC-Obstructive Airways Disease: a Longitudinal Observational Study

Twenty-Year Reflection on the Impact of World Trade Center Exposure on Pulmonary Outcomes in Fire Department of the City of New York (FDNY) Rescue and Recovery Workers

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