Validation of Musculoskeletal Ultrasound to Assess and Quantify Muscle Glycogen Content. A Novel Approach

Hill, John C.; Millán, Íñigo San

doi:10.3810/psm.2014.09.2075

Cited by 62 publications

(101 citation statements)

References 38 publications

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“…For example, Pillen et al (2009) demonstrated that increases in interstitial fibrous and fat tissues were associated ( r = 0.87) with increases in echo intensity. Hill and Millan (2014) and Nieman et al (2015) showed that changes in rectus femoris and vastus lateralis echo intensity are strongly related ( r = 0.88–0.92) to changes in skeletal muscle glycogen content following cycling exercise. Although, several previous studies have demonstrated decreases in echo intensity following chronic resistance training (Pinto et al, 2014; Radaelli et al, 2014), Radaelli et al (2014) suggested that the mechanism for changes in echo intensity is unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Ultrasound echo intensity has also been used as a surrogate of muscle quality (Pillen et al, 2009; Arts et al, 2012; Fukumoto et al, 2012; Radaelli et al, 2013) and as an indicator of skeletal muscle glycogen content and tissue hydration (Sarvazyan et al, 2005; Hill and Millan, 2014; Nieman et al, 2015). For example, Pillen et al (2009) demonstrated that increases in interstitial fibrous and fat tissues were associated ( r = 0.87) with increases in echo intensity.…”

Section: Discussionmentioning

confidence: 99%

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Greater Neural Adaptations following High- vs. Low-Load Resistance Training

et al. 2017

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We examined the neuromuscular adaptations following 3 and 6 weeks of 80 vs. 30% one repetition maximum (1RM) resistance training to failure in the leg extensors. Twenty-six men (age = 23.1 ± 4.7 years) were randomly assigned to a high- (80% 1RM; n = 13) or low-load (30% 1RM; n = 13) resistance training group and completed leg extension resistance training to failure 3 times per week for 6 weeks. Testing was completed at baseline, 3, and 6 weeks of training. During each testing session, ultrasound muscle thickness and echo intensity, 1RM strength, maximal voluntary isometric contraction (MVIC) strength, and contractile properties of the quadriceps femoris were measured. Percent voluntary activation (VA) and electromyographic (EMG) amplitude were measured during MVIC, and during randomly ordered isometric step muscle actions at 10–100% of baseline MVIC. There were similar increases in muscle thickness from Baseline to Week 3 and 6 in the 80 and 30% 1RM groups. However, both 1RM and MVIC strength increased from Baseline to Week 3 and 6 to a greater degree in the 80% than 30% 1RM group. VA during MVIC was also greater in the 80 vs. 30% 1RM group at Week 6, and only training at 80% 1RM elicited a significant increase in EMG amplitude during MVIC. The peak twitch torque to MVIC ratio was also significantly reduced in the 80%, but not 30% 1RM group, at Week 3 and 6. Finally, VA and EMG amplitude were reduced during submaximal torque production as a result of training at 80% 1RM, but not 30% 1RM. Despite eliciting similar hypertrophy, 80% 1RM improved muscle strength more than 30% 1RM, and was accompanied by increases in VA and EMG amplitude during maximal force production. Furthermore, training at 80% 1RM resulted in a decreased neural cost to produce the same relative submaximal torques after training, whereas training at 30% 1RM did not. Therefore, our data suggest that high-load training results in greater neural adaptations that may explain the disparate increases in muscle strength despite similar hypertrophy following high- and low-load training programs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Greater Neural Adaptations following High- vs. Low-Load Resistance Training

et al. 2017

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“…New cutting edge ultrasound technology [45] is being utilized routinely by the world's most elite professional athletes (i.e. Tour de France) to directly measure muscle glycogen in a few minutes at the bedside[45].…”

Section: Metabolic Response To Icu- Relationship To Exercise Stress Amentioning

confidence: 99%

“…Tour de France) to directly measure muscle glycogen in a few minutes at the bedside[45]. This technology is utilized by athletes to predict and prevent overtraining and guide nutritional needs during training.…”

Section: Metabolic Response To Icu- Relationship To Exercise Stress Amentioning

confidence: 99%

Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise

Wischmeyer

Puthucheary

Millán

et al. 2017

Current Opinion in Critical Care

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Purpose of Review We have significantly improved hospital mortality from sepsis and critical illness in last 10 years, however over this same period we have tripled the number of “ICU survivors” going to rehabilitation. Further, as up to half the deaths in the first year following ICU admission occur post-ICU discharge, it is unclear how many of these patients ever returned home or a meaningful quality of life (QoL). For those who do survive, recent data reveals many “ICU survivors” will suffer significant functional impairment or Post-ICU Syndrome (PICS). Thus, new innovative metabolic and exercise interventions to address PICS are urgently needed. These should focus on optimal nutrition and lean body mass (LBM) assessment, targeted nutrition delivery, anabolic/anti-catabolic strategies, and utilization of personalized exercise intervention techniques, such as utilized by elite athletes to optimize preparation and recovery from critical care. Recent findings New data for novel LBM analysis technique such as CT scan and ultrasound analysis of lean body mass are available showing objective measures of LBM now becoming more practical for predicting metabolic reserve and effectiveness of nutrition/exercise interventions. 13C-breath testing is a novel technique under study to predict infection earlier and predict over- and under-feeding to target nutrition delivery. New technologies utilized routinely by athletes such as muscle glycogen ultrasound also show promise. Finally, the role of personalized cardiopulmonary exercise testing (CPET) to target pre-operative exercise optimization and post-ICU recovery are becoming reality. Summary New innovative techniques are demonstrating promise to target recovery from PICS utilizing a combination of objective LBM and metabolic assessment, targeted nutrition interventions, personalized exercise interventions for prehabilitation and post-ICU recovery. These interventions should provide hope that we will soon begin to create more “survivors” and fewer victim's post-ICU care.

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“…It employs a portable device and cloud-based software. In a study funded by MuscleSound and led by the founder of the company, elite cyclists had muscle glycogen assessed before and after an intense bout of ergometer cycling [ 44 ]. The ultrasound value of muscle glycogen change compared favorably to that obtained with muscle biopsies ( r = 0.81).…”

Section: Misdirected: Indirect and Direct Measuresmentioning

confidence: 99%

Beyond the Obvious: Future Innovations in Sports Nutrition

Almada¹

2015

Nutritional Supplements in Sports and Exercise

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The global proliferation of sports nutrition brands is emblematic of the size of consumers seeking enhancements through this class of ingestible products. However, a nearly ubiquitous theme of commonality is shared by these products: the compositions are often close to identical, differing only by amount and description, with ancillary alterations in fl avor or packaging. How many branched chain amino acid or whey protein compositions can be birthed? The future of sports nutrition will continue to witness the penetration of multinational (food, beverage, and pharma) brands entering the fray through acquisition, and patent fi lings, which may foster a generic storm or heightened innovation. What remains most compelling is the opportunity for true innovation and pioneering to disrupt the highly duplicative sports nutrition product landscape. Such adventurous excursions may include systematic research/innovation programs that provide novelty, compelling proof of concept, and "real-world" utility; implementation of research methods that provide direct, inferential insights into the bioavailability and metabolism of bioactives; and novel protein/amino nitrogen sources that mimic the biological effects of whey protein.

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Validation of Musculoskeletal Ultrasound to Assess and Quantify Muscle Glycogen Content. A Novel Approach

Abstract: These results demonstrate that skeletal muscle glycogen can be measured quickly and noninvasively through high-frequency ultrasound using MuscleSound technology.

Cited by 62 publications

References 38 publications

Greater Neural Adaptations following High- vs. Low-Load Resistance Training

Greater Neural Adaptations following High- vs. Low-Load Resistance Training

Muscle mass and physical recovery in ICU: innovations for targeting of nutrition and exercise

Beyond the Obvious: Future Innovations in Sports Nutrition

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