Validation of micro-computed tomography for occlusal caries detection: an in vitro study

Özkan, Gökhan; Kanlı, Aydan; Başeren, Nurdan Meserret; Arslan, Ümüt; Tatar, İlkan

doi:10.1590/1807-3107bor-2015.vol29.0132

Cited by 35 publications

(43 citation statements)

References 24 publications

(46 reference statements)

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“…This was also the case for conceptual papers and other reviews (not primary studies). Neuhaus et al [2011] 0.73 (0.21, 1.25) Jallad et al [2015] 0.88 (0.80, 0.96) Ekstrand et al [2011] 0.96 (0.83, 1.09) Diniz et al [2011] 0.89 (0.86, 0.92) Souza et al [2013] 0.92 (0.72, 1.12) Gomez et al [2013] 0.85 (0.56, 1.14) Cotta et al [2015] Ekstrand et al [2011] 0.91 (0.78, 1.04) Castilho et al [2016] 0.60 (0.24, 0.96) Ozkan et al [2015] 0.76 (0.38, 1.14) Ko et al [2015] 0.96 (0.94, 0.96) Ekstrand et al [2007] 0. 85 (0.65 Forest plots for meta-analysis and heterogeneity analysis of intra-and inter-examiner reproducibility when ICDAS was used for assessing caries lesion severity.…”

Section: Systematic Review: the Accuracy Of The Icdas In Detectingmentioning

confidence: 99%

The International Caries Detection and Assessment System – ICDAS: A Systematic Review

et al. 2018

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The aims of this study were: (1) to evaluate the overall reproducibility and accuracy of the International Caries Detection and Assessment System (ICDAS) for assessing coronal caries lesions, and (2) to investigate the use of systems associated with the ICDAS for activity assessment of coronal caries lesions. Specific search strategies were adopted to identify studies published up to 2016. For the first objective, we selected studies that assessed primary coronal caries lesions using the ICDAS as a reference standard. A total of 54 studies were included. Meta-analyses summarized the results concerning reproducibility and accuracy (correlation with histology, summary ROC curves [SROC], and diagnostic odds ratio [DOR]). The latter 2 were expressed at D1/D3 levels. The heterogeneity of the studies was also assessed. Reproducibility values (pooled) were > 0.65. The ICDAS mostly presented a good overall performance as most areas under SROC were > 0.75 at D1 and > 0.90 at D3; DOR ≥6. For the second objective, we selected studies investigating activity assessment associated with the ICDAS. The meta-analyses pooled results based on the same methodology and parameters as above. Longitudinal findings regarding caries progression were described to estimate the validity of these systems. On average, the systems for activity assessment of caries lesions showed moderate values concerning reproducibility and overall performance. Active caries lesions were more prone to progress than inactive ones after 2 years. In conclusion, the ICDAS presented a substantial level of reproducibility and accuracy for assessing primary coronal caries lesions. Additional systems associated with the ICDAS that classify caries lesion activity can be useful as they are moderately reproducible and accurate.

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Section: Systematic Review: the Accuracy Of The Icdas In Detectingmentioning

confidence: 99%

The International Caries Detection and Assessment System – ICDAS: A Systematic Review

et al. 2018

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“…In fact, a recent study has shown that this method correlates well with a histological gold standard (0.917 for accuracy and 0.949 for AUC) when visual scores for the presence of caries are compared. 9 Some advantages of the micro-CT method is that it is non-destructive and provides mineral density values as outcomes of caries presence instead of possibly relying on dentin reactions to caries rather than on the effect of tissue demineralization. 10 Moreover, micro-CT allows threedimensional visualization and quantification of sound and diseased tissues.…”

Section: Discussionmentioning

confidence: 99%

“…7 Although most studies on sensitivity, specificity, reproducibility, and accuracy of dental caries diagnostic tools are performed against a histological gold standard (stereomicroscopy), 8 more recently, laboratory non-destructive methods have been proposed as possible surrogate gold standards for detection of carious lesions. 9 Histological detection of caries has some limitations, including the destructive and two-dimensional approach, difficulties in discriminating between histological dentin reactions and true demineralization, 10 and the applied qualitative-based scoring system, which may vary among studies. 11,12 Micro-CT is a laboratory non-destructive technique which allows reconstruction of linear attenuation coefficients measured from a series of X-ray projections into a pattern of gray scale values throughout the object's volume.…”

Section: Introductionmentioning

confidence: 99%

Accuracy of visual and image-based ICDAS criteria compared with a micro-CT gold standard for caries detection on occlusal surfaces

et al. 2018

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The aim of this study was to check the in vitro accuracy of ICDAS criteria on digital images compared to visual examination for the diagnosis of occlusal caries against a micro-CT gold standard. ICDAS was scored in 40 extracted permanent molars by means of visual inspection and stereomicroscopic images. Visual examinations were performed in duplicate and at a one-week interval by three different calibrated examiners. The analysis of digital images by ICDAS criteria was also performed in duplicate, 1 month after visual examinations. The detection methods were compared by means of sensitivity, specificity, area under the curve, predictive positive and negative values, and accuracy for two different thresholds (1- sound vs. carious teeth; 2- tooth requiring operative vs. non-operative treatment). Sensitivity and accuracy values for threshold 1 in the visual ICDAS and image-based ICDAS methods were high for sensitivity (0.93 and 0.97) and for accuracy (0.83 and 0.85), but low for specificity (0.55 for both methods). Specificity values for threshold 2 were 0.77 and 0.82, while sensitivity was 0.33 and 0.28 for each method. Spearman's rank correlation coefficient was 0.53 and 0.43 (p<0.05) for visual and image-based ICDAS compared to the gold standard scores. Both visual and image-based ICDAS scores were similar to each other in terms of diagnostic accuracy when compared to the micro-CT gold standard. Low specificity for the presence of caries and sensitivity for the detection of caries requiring operative treatment were found.

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“…On the other hand, µCT provides nonoverlapping 3D imaging of the dental structure where mineral density can be estimated in large volume areas. Prior studies have validated µCT for the detection of occlusal and proximal caries [Mitropoulos et al, 2010;Taylor et al, 2010;Soviero et al, 2012;Ozkan et al, 2015], and more recently it has been reported to be an alternative to histological sectioning of carious tissue [Boca et al, 2017]. Despite the differences between methods, there were outcome similarities for the high remineralization (A, B, and C mints and GT) and low remineralization (xylitol) groups.…”

Section: Discussionmentioning

confidence: 99%

Remineralization Potential of Mints Containing Bioactive Agents in Artificially Induced Root Caries

Zamperini

Bedran-Russo²

2018

Caries Res

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This study investigated the remineralization effect of experimental mint formulations containing bioactive agents (xylitol; green tea extract, GT; and amorphous calcium phosphate, ACP) in the progression of artificially induced root caries. Root caries lesions were induced by demineralization solution (pH 4.6; 96 h; 37°C). The lesions were treated with mint A, mint B, mint C, xylitol, GT, ACP, or remineralization solution (RS; negative control). Specimens were pH-cycled through treatments (5×/day; 3 min) and 6 cycles of acidic (pH 5.0; 30 min) and neutral (pH 7.0; 10 min) buffers for 8 days. Bacterial collagenase (Clostridium histolyticum) was used overnight to simulate proteolytic challenge. Caries depth and porosity as well as mineral density were estimated using fluorescence microscopy (n = 15) and microcomputed tomography (n = 6). Analysis of variance (ANOVA, α = 0.05) showed no statistically significant difference in caries depth among all groups (p = 0.172). The highest fluorescence intensity decrease was observed for GT followed by mint C, with no significant difference between them (p = 0.868). There were significant differences among GT and mints A, B, and C when compared to RS (p < 0.001). No statistically significant differences in fluorescence intensity were observed among ACP, xylitol, and RS (p > 0.05). The mineral density of the lesions in GT, mints A, B, and C, and ACP was statistically similar (p > 0.05) and significantly higher than that in RS (p < 0.05). No significant difference was observed between xylitol and RS (p = 0.728). The experimental mints showed remineralization action on artificial root caries, and GT was found to be the main active ingredient in the investigated formulations.

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Validation of micro-computed tomography for occlusal caries detection: an in vitro study

Cited by 35 publications

References 24 publications

The International Caries Detection and Assessment System – ICDAS: A Systematic Review

The International Caries Detection and Assessment System – ICDAS: A Systematic Review

Accuracy of visual and image-based ICDAS criteria compared with a micro-CT gold standard for caries detection on occlusal surfaces

Remineralization Potential of Mints Containing Bioactive Agents in Artificially Induced Root Caries

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