Validation of green tea polyphenol biomarkers in a phase II human intervention trial

Wang, Jiasheng; Luo, Haitao; Wang, Piwen; Tang, Lili; Yu, Jiahua; Huang, Tianren; Cox, Stephen B.; Gao, Weimin

doi:10.1016/j.fct.2007.08.007

Cited by 47 publications

(37 citation statements)

References 35 publications

(32 reference statements)

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“…Moreover, numerous human intervention and bioavailability studies using green tea extracts or EGCG have reported no serious adverse effects from their use (Wang et al 2008;Abboud et al 2008;Mochizuki and Hasegawa 2010). On AST (U\L)…”

Section: Discussionmentioning

confidence: 99%

High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions

Inoue

Akiyama

Maeda‐Yamamoto

et al. 2011

Cell Stress and Chaperones

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Previously, we reported that oral feeding of 1% green tea polyphenols (GTPs) aggravated the dextran sulfate sodium (DSS)-induced colitis in mice. In the present study, we assessed the toxicity of 1% GTPs in several organs from normal and DSS-exposed mice. Sixty-two male ICR mice were initially divided into four groups. Nontreated group (group 1, n=15) was given standard diet and water, GTPs (group 2, n=15) received 1% GTPs in diet and water, DSS (group 3, n=15) received diet and 5% DSS in water, and GTPs + DSS group (group 4, n=17) received 1% GTPs in diet and 5% DSS in water. We found that group 4 significantly increased (P<0.05) kidney weight, the levels of serum creatinine and thiobarbituric acid-reactive substances in both kidney and liver, as compared with those in group 3. The mRNA expression levels of antioxidant enzymes and heat-shock proteins (HSPs) in group 4 were lower than those of group 3. For instance, heme oxygenase-1 (HO-1), HSP27, and 90 mRNA in the kidney of group 4 were dramatically down-regulated as compared with those of group 3. Furthermore, 1% GTPs diet decreased the expression of HO-1, NAD(P)H:quinone oxidoreductase 1 (NQO1) and HSP90 in kidney and liver of non-treated mice. Taken together, our results indicate that high-dose GTPs diet disrupts kidney functions through the reduction of antioxidant enzymes and heat-shock protein expressions in not only colitis but also non-treated ICR mice.

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Section: Discussionmentioning

confidence: 99%

High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions

Inoue

Akiyama

Maeda‐Yamamoto

et al. 2011

Cell Stress and Chaperones

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“…The placebo rats also had free access to no GTP (P group) or 0.5% GTP drinking water (PG group) throughout the study period. The 0.5% concentration of GTP in drinking water daily mimics human consumption of green tea of 4 cups a day based on our previous human [20] and animal studies [15,21]. All rats were fed a rodent chow diet ad libitum during the 12-week feeding period.…”

Section: Animals and Gtp Treatmentsmentioning

confidence: 99%

Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation

et al. 2010

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“…A dose of 110 mg/day of phytosome given for 30 days revealed the enhanced level of α-tocopherol in RBCs in addition to higher PUFA levels. It has been found that these phytosomes reduce the oxidative stress in body (Wang et al 2008). These phytosomes have been found to enhance the pumping of heart, and increase prostacyclins into blood circulation.…”

Section: Drug Deliverymentioning

confidence: 97%

Liposomal and Phytosomal Formulations

Guliani

Singla

Kumari

et al. 2016

Nanoscale Materials in Targeted Drug Delivery, Theragnosis and Tissue Regeneration

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Liposomes and phytosomes are kind of nanoparticles (NPs) which serve as an imperative tool for the delivery of various bioactive molecules. The molecules possessing lesser water solubility, bioavailability and retention time are encapsulated into both of these formulations. More specifically, liposomes can encapsulate both hydrophobic as well as hydrophilic molecules. While phytosomes contain only plant-based molecules having poor solubility in biological media like flavanones and terpenes. The various advantages of liposomes and phytosomes like biocompatibility, nontoxicity, ease to administer, decrease in dosage and increase in retention time make them potent vehicles for the drug delivery of various molecules. These nanoformulations find potential applications for delivery of various bioactive molecules, in tissue regeneration and as antimicrobials. This chapter highlights the importance of liposomes and phytosomes, methods of their preparation, mechanism of their action and applications.

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Validation of green tea polyphenol biomarkers in a phase II human intervention trial

Cited by 47 publications

References 35 publications

High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions

High-dose green tea polyphenols induce nephrotoxicity in dextran sulfate sodium-induced colitis mice by down-regulation of antioxidant enzymes and heat-shock protein expressions

Green tea polyphenols attenuate deterioration of bone microarchitecture in female rats with systemic chronic inflammation

Liposomal and Phytosomal Formulations

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