Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus

Lalou, Afroditi D; Levrini, Virginia; Garnett, Matthew; Nabbanja, Eva; Kim, Dong-Joo; Gergelé, Laurent; Bjornson, Anna; Czosnyka, Zofia; Czosnyka, Marek

doi:10.1007/s00701-018-3497-9

Cited by 4 publications

(2 citation statements)

References 26 publications

(37 reference statements)

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“…a reduction in the cross-sectional area of the sagittal sinus of 35%, a 30% reduction in the transverse sinuses and 41% reduction in the sigmoid sinuses compared to controls 28 . An increase in the CSF outflow resistance in hydrocephalus will increase the CSF pressure with respect to the venous pressure 30 (i.e. the transmural pressure) accounting for the sinus compression in hydrocephalus.…”

Section: Similarities Between Sans and Hydrocephalusmentioning

confidence: 99%

“…The authors suggested there may be venous obstruction downstream, outside of the cranium or venous laxity in the SANS individuals, in comparison to the non-SANS individuals, to account for the findings but also noted the difficulty in explaining the dilatation given that most astronauts appear to have an elevated post-flight ICP 25 . The CSF pressure should always stay above the venous sinus pressure for CSF to drain via this route 30 . The free walls of the sinuses are fixed at their inner attachments to the falx or tentorium cerebri and also their outer attachments to the inner aspect of the skull 31 .…”

Section: Similarities Between Sans and Hydrocephalusmentioning

confidence: 99%

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A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue

Bateman,

Bateman

2024

npj Microgravity

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Spaceflight associated neuro-ocular syndrome (SANS) alters the vision of astronauts during long-duration spaceflights. Previously, the current authors have discussed the similarities and differences between SANS and idiopathic intracranial hypertension to try to elucidate a possible pathophysiology. Recently, a theory has been advanced that SANS may occur secondary to failure of the glymphatic system caused by venous dilatation within the brain and optic nerves. There is recent evidence to suggest glymphatic obstruction occurs in childhood hydrocephalus, multiple sclerosis and syringomyelia due to venous outflow dilatation similar to that proposed in SANS. The purpose of the current paper is to discuss the similarities and differences between the known CSF and venous pathophysiology in SANS with these other terrestrial diseases, to see if they can shed any further light on the underlying cause of this microgravity-induced disease.

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Section: Similarities Between Sans and Hydrocephalusmentioning

confidence: 99%

Section: Similarities Between Sans and Hydrocephalusmentioning

confidence: 99%

A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue

Bateman,

Bateman

2024

npj Microgravity

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Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications

Geregele¹,

Balédent²,

Manet³

et al. 2019

Biomechanics of the Brain

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Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly

Lalou

Levrini

Czosnyka

et al. 2020

Fluids Barriers CNS

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Background: Post-traumatic hydrocephalus (PTH) is potentially under-diagnosed and under-treated, generating the need for a more efficient diagnostic tool. We aim to report CSF dynamics of patients with post-traumatic ventriculomegaly. Materials and methods: We retrospectively analysed post-traumatic brain injury (TBI) patients with ventriculomegaly who had undergone a CSF infusion test. We calculated the resistance to CSF outflow (Rout), AMP (pulse amplitude of intracranial pressure, ICP), dAMP (AMPplateau-AMPbaseline) and compensatory reserve index correlation coefficient between ICP and AMP (RAP). To avoid confounding factors, included patients had to be non-decompressed or with cranioplasty > 1 month previously and Rout > 6 mmHg/min/ml. Compliance was assessed using the elasticity coefficient. We also compared infusion-tested TBI patients selected for shunting versus those not selected for shunting (consultant decision based on clinical and radiological assessment and the infusion results). Finally, we used data from a group of shunted idiopathic Normal Pressure Hydrocephalus (iNPH) patients for comparison. Results: Group A consisted of 36 patients with post-traumatic ventriculomegaly and Group B of 45 iNPH shunt responders. AMP and dAMP were significantly lower in Group A than B (0.55 ± 0.39 vs 1.02 ± 0.72; p < 0.01 and 1.58 ± 1.21 vs 2.76 ± 1.5; p < 0.01. RAP baseline was not significantly different between the two. Elasticity was higher than the normal limit in all groups (average 0.18 1/ml). Significantly higher Rout was present in those with probable PTH selected for shunting compared with unshunted. Mild/moderate hydrocephalus, ex-vacuo ventriculomegaly/ encephalomalacia were inconsistently reported in PTH patients. Conclusions: Rout and AMP were significantly lower in PTH compared to iNPH and did not always reflect the degree of hydrocephalus or atrophy reported on CT/MRI. Compliance appears reduced in PTH.

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Validation of Davson’s equation in patients suffering from idiopathic normal pressure hydrocephalus

Cited by 4 publications

References 26 publications

A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue

A perspective on the evidence for glymphatic obstruction in spaceflight associated neuro-ocular syndrome and fatigue

Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications

Cerebrospinal fluid dynamics in non-acute post-traumatic ventriculomegaly

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