Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications

Geregele, Laurent; Balédent, Olivier; Manet, Romain; Lalou, Afroditi D; Barszcz, Sławomir; Kasprowicz, Magdalena; Śmielewski, Piotr; Pickard, John D.; Czosnyka, Marek; Czosnyka, Zofia

doi:10.1007/978-3-030-04996-6_8

Cited by 6 publications

(3 citation statements)

References 67 publications

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“…The CSF can be generated and eliminated in several ways: while the relative contributions of these different mechanisms remain unclear (Wagshul et al, 2011), there are multiple lines of evidence indicating that the majority of the CSF surrounding the spinal cord was produced in the brain and exited the skull at the foramen magnum (Magnaes, 1989;Geregele et al, 2019). Recent work on zebra fish embryos have shown that lateral deflection of the body, as is produced by skeletal muscle during locomotion, results in significant unidirectional flow of CSF (Olstad et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

The myodural bridge of the American alligator (Alligator mississippiensis) alters CSF flow

Young

Adams

Beary

et al. 2020

Journal of Experimental Biology

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Disorders of the volume, pressure or circulation of the cerebrospinal fluid (CSF) lead to disease states in both newborns and adults; despite this significance, there is uncertainty regarding the basic mechanics of the CSF. The suboccipital muscles connect to the dura surrounding the spinal cord, forming a complex termed the ‘myodural bridge’. This study tests the hypothesis that the myodural bridge functions to alter the CSF circulation. The suboccipital muscles of American alligators were surgically exposed and electrically stimulated simultaneously with direct recordings of CSF pressure and flow. Contraction of the suboccipital muscles significantly changed both CSF flow and pressure. By demonstrating another influence on CSF circulation and pulsatility, the present study increases our understanding of the mechanics underlying the movement of the CSF.

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Section: Resultsmentioning

confidence: 99%

The myodural bridge of the American alligator (Alligator mississippiensis) alters CSF flow

Young

Adams

Beary

et al. 2020

Journal of Experimental Biology

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“…This further prevented CSF leakage and created a robust anchoring point for the catheter. The main limitations of the present study were: (1) the implanted catheters could not record CSF flow rates; (2) alligators have variation in their CSF fluid dynamics [ 46 ] similar to humans [ 8 ]; and (3) some of the movements analyzed in this study were performed manually, which produced additional variation.…”

Section: Discussionmentioning

confidence: 99%

“…To fulfill either functional role, the CSF must circulate; studies have postulated that abnormal CSF circulation may cause a variety of neurological disorders, including syringomyelia [ 3 ], Alzheimer’s disease [ 4 ], and hydrocephalus [ 5 , 6 , 7 ]. Despite the recognized importance of the CSF fluid mechanics, little is known about the magnitude, or dynamic range, of “normal” CSF pressure [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

The Influence of Movement on the Cerebrospinal Fluid Pressure of the American Alligator (Alligator mississippiensis)

Young

Cramberg

2022

Biology

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This study was undertaken to document how the cerebrospinal fluid (CSF) pressure varied during movements and physiological activities. Using surgically implanted pressure catheters; the CSF pressure was recorded from sub-adult American alligators (Alligator mississippiensis) under anesthesia and post-recovery. Pressures were recorded during physiological activities (the cardiac cycle; passive and active ventilation); manual manipulation of the anesthetized animals (foot sweeps; tail oscillations; and body bends); as well as voluntary movements post-recovery (changes in body tone; defensive strikes; and locomotion). The CSF pulsations associated with the cardiac cycle had the lowest mean amplitude (3.7 mm Hg); during active ventilation and defensive strikes; the alligators routinely generated CSF pressure spikes in excess of 100 mm Hg. The recorded CSF pressures appear to be caused by a variety of mechanisms including vascular pressure; fluid inertia; and possible physical displacement of the spinal cord. The results of the study suggest that any model of CSF dynamics or perfusion should incorporate the episodic high-pressure CSF pulsations associated with movement

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External Hydrocephalus After Traumatic Brain Injury: Retrospective Study of 102 Patients

Gergelé

Manet²,

Kolias

et al. 2021

Acta Neurochirurgica Supplement

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Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications

Cited by 6 publications

References 67 publications

The myodural bridge of the American alligator (Alligator mississippiensis) alters CSF flow

The myodural bridge of the American alligator (Alligator mississippiensis) alters CSF flow

The Influence of Movement on the Cerebrospinal Fluid Pressure of the American Alligator (Alligator mississippiensis)

External Hydrocephalus After Traumatic Brain Injury: Retrospective Study of 102 Patients

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