Validation of an In Vivo Medical Image-Based Young Human Lumbar Spine Finite Element Model

Mills, Matthew J.; Sarigul‐Klijn, Nesrin

doi:10.1115/1.4042183

Cited by 16 publications

(8 citation statements)

References 55 publications

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“…For the fusion and MACDVC-AM model, the interfaces at the implant-endplate and screw-bone were defined as a tied contact condition to simulate a complete fusion status [ 23 ]. Finally, a convergence analysis in vertebral and disc meshes was conducted to ensure that the maximum changes in the strain energy were less than 5% [ 24 ]. The mesh element numbers are presented in Table 1 .…”

Section: Methodsmentioning

confidence: 99%

Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis

Ouyang

et al. 2022

J Orthop Surg Res

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Background Changes in spinal mobility after vertebral fusion are important factors contributing to adjacent vertebral disease (ASD). As an implant for spinal non-fusion, the motion-preserving prosthesis is an effective method to reduce the incidence of ASD, but its deficiencies hamper the application in clinical. This study designs a novel motion-preserving artificial cervical disc and vertebra complex with an anti-dislocation mechanism (MACDVC-AM) and verifies its effect on the cervical spine. Methods The MACDVC-AM was designed on the data of healthy volunteers. The finite element intact model, fusion model, and MACDVC-AM model were constructed, and the range of motion (ROM) and stress of adjacent discs were compared. The biomechanical tests were performed on fifteen cervical specimens, and the stability index ROM (SI-ROM) were calculated. Results Compared with the intervertebral ROMs of the intact model, the MACDVC-AM model reduced by 28–70% in adjacent segments and increased by 26–54% in operated segments, but the fusion model showed the opposite result. In contrast to the fusion model, the MACDVC-AM model diminished the stress of adjacent intervertebral discs. In biomechanical tests, the MACDVC-AM group showed no significant difference with the ROMs of the intact group (p > 0.05). The SI-ROM of the MACDVC-AM group is negative but close to zero and showed no significant difference with the intact group (p > 0.05). Conclusions The MACDVC-AM was successfully designed. The results indicate that the MACDVC-AM can provide physiological mobility and stability, reduce adjacent intervertebral compensatory motion, and alleviate the stress change of adjacent discs, which contributes to protect adjacent discs and reduce the occurrence of ASD.

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Section: Methodsmentioning

confidence: 99%

Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis

Ouyang

et al. 2022

J Orthop Surg Res

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“…Most models are created from computed tomography (CT) scans, either directly or by the scaling of a previous model, however, the musculature is rarely included. A few studies have focused on the creation and validation of models 26,27 . The model developed from CT images by Mills and Sarigul‐Klijn is one of the first young (20 years) female models 27 .…”

Section: Methodsmentioning

confidence: 99%

“…A few studies have focused on the creation and validation of models. 26 , 27 The model developed from CT images by Mills and Sarigul‐Klijn is one of the first young (20 years) female models. 27 This provided an initial model for future studies on the young female spine.…”

Section: Methodsmentioning

confidence: 99%

“…Other studies have modelled the individual components of the IVJ. Linear 32 and non‐linear models 26 , 27 , 28 , 34 , 35 , 37 , 49 , 51 have been used for the IVD, often modelling the nucleus pulposus and the annulus fibrosus separately. Non‐linear hyperelastic equations described the RoM much better than linear equations.…”

Section: Methodsmentioning

confidence: 99%

“… 122 , 123 Further, validation using the FJF was challenging due to the conflicting and limited data available within the literature. 26 Large and conclusive data sets for IDP and FJF would significantly aid the validation of spine models, 26 , 27 and data sets from scoliotic spines would greatly support the verification of scoliotic spine models.…”

Section: Methodsmentioning

confidence: 99%

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Computational modelling of the scoliotic spine: A literature review

Gould¹,

Cristofolini

Davico³

et al. 2021

Numer Methods Biomed Eng

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Scoliosis is a deformity of the spine that in severe cases requires surgical treatment. There is still disagreement among clinicians as to what the aim of such treatment is as well as the optimal surgical technique. Numerical models can aid clinical decision‐making by estimating the outcome of a given surgical intervention. This paper provided some background information on the modelling of the healthy spine and a review of the literature on scoliotic spine models, their validation, and their application. An overview of the methods and techniques used to construct scoliotic finite element and multibody models was given as well as the boundary conditions used in the simulations. The current limitations of the models were discussed as well as how such limitations are addressed in non‐scoliotic spine models. Finally, future directions for the numerical modelling of scoliosis were addressed.

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Biomechanical modelling of the facet joints: a review of methods and validation processes in finite element analysis

Mengoni

2020

Biomech Model Mechanobiol

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There is an increased interest in studying the biomechanics of the facet joints. For in silico studies, it is therefore important to understand the level of reliability of models for outputs of interest related to the facet joints. In this work, a systematic review of finite element models of multi-level spinal section with facet joints output of interest was performed. The review focused on the methodology used to model the facet joints and its associated validation. From the 110 papers analysed, 18 presented some validation of the facet joints outputs. Validation was done by comparing outputs to literature data, either computational or experimental values; with the major drawback that, when comparing to computational values, the baseline data was rarely validated. Analysis of the modelling methodology showed that there seems to be a compromise made between accuracy of the geometry and nonlinearity of the cartilage behaviour in compression. Most models either used a soft contact representation of the cartilage layer at the joint or included a cartilage layer which was linear elastic. Most concerning, soft contact models usually did not contain much information on the pressure-overclosure law. This review shows that to increase the reliability of in silico model of the spine for facet joints outputs, more needs to be done regarding the description of the methods used to model the facet joints, and the validation for specific outputs of interest needs to be more thorough, with recommendation to systematically share input and output data of validation studies.

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Validation of an In Vivo Medical Image-Based Young Human Lumbar Spine Finite Element Model

Cited by 16 publications

References 55 publications

Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis

Cervical non-fusion using biomimetic artificial disc and vertebra complex: technical innovation and biomechanics analysis

Computational modelling of the scoliotic spine: A literature review

Biomechanical modelling of the facet joints: a review of methods and validation processes in finite element analysis

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