Validation of an Evacuated Canister Method for Measuring Part-Per-Billion Levels of Chemical Warfare Agent Simulants

Coffey, Christopher C.; LeBouf, Ryan F.; Calvert, Catherine A.; Slaven, James E.

doi:10.3155/1047-3289.61.8.826

Cited by 7 publications

(4 citation statements)

References 18 publications

(16 reference statements)

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“…Coffey et al performed a similar method validation study for fused-silica lined, evacuated-canister air sampling analyzed using a microscale purge and trap preconcentrator configuration. 17 They found that acetone passed the accuracy criterion but failed the stability criterion, while the current study found that acetone passed both the accuracy and stability criteria. Also, LODs established by Coffey et al 17 were not so low as those established in the current study, presumably due to a difference in trap configurations.…”

Section: Discussionmentioning

confidence: 41%

“…17 They found that acetone passed the accuracy criterion but failed the stability criterion, while the current study found that acetone passed both the accuracy and stability criteria. Also, LODs established by Coffey et al 17 were not so low as those established in the current study, presumably due to a difference in trap configurations. In contrast to the Coffey et al study, the preconcentrator configuration for the current study did not employ a sorbent in trap 2.…”

Section: Discussionmentioning

confidence: 41%

“…To our knowledge, the current study and a study by Coffey et al 8 are the only published method validation studies for evacuated-canister air sampling that have used the NIOSH guidelines. 17 The current study is the first to provide method validation data for VOC air contaminants at ppm-and ppb-level concentrations.…”

Section: Discussionmentioning

confidence: 99%

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Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings

2012

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Healthcare settings present a challenging environment for assessing low-level concentrations of specific volatile organic compounds (VOCs) in the presence of high background concentrations of alcohol from the use of hand sanitizers and surface disinfectants. The purposes of this laboratory-based project were to develop and validate a sampling and analysis methodology for quantifying low-level VOC concentrations as well as high-level alcohol concentrations found together in healthcare settings. Sampling was conducted using evacuated canisters lined with fused silica. Gas chromatography/mass spectrometry analysis was performed using preconcentration (for ppb levels) and loop injection (for ppm levels). For a select list of 14 VOCs, bias, precision, and accuracy of both the preconcentration and loop injection methods were evaluated, as was analyte stability in evacuated canisters over 30 days. Using the preconcentration (ppb-level) method, all validation criteria were met for 13 of the 14 target analytes-ethanol, acetone, methylene chloride, hexane, chloroform, benzene, methyl methacrylate, toluene, ethylbenzene, m,p-xylene, o-xylene, alpha-pinene, and limonene. Using the loop injection (ppm-level) method, all validation criteria were met for each analyte. At ppm levels, alpha-pinene and limonene remained stable over 21 days, while the rest of the analytes were stable for 30 days. All analytes remained stable over 30 days at ppb levels. This sampling and analysis approach is a viable (i.e., accurate and stable) methodology that will enable development of VOC profiles for mixed exposures experienced by healthcare workers.

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Section: Discussionmentioning

confidence: 41%

Section: Discussionmentioning

confidence: 41%

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Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings

2012

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“…The coating on state-of-the-art canisters prevents many VOCs from reacting with canister walls and allows for high stability for up to a month or longer. Canisters provide detection limits in the part per trillion range and often display precisions of less than 15% for re-analysis, which is within the ASTM criteria of +/− 30% [ 32 , 33 , 34 , 35 ]. The acceptance range in commonly conducted inter-laboratory comparison studies of method TO-15 using replicate samples has demonstrated considerably wider ranges [ 32 ].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Long-Term Flow Controller for Monitoring Gases and Vapors in Buildings Impacted by Vapor Intrusion

Rossner

Wick

Lutes

et al. 2023

IJERPH

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This study evaluated the use of a long-term capillary flow controller paired with an evacuated canister for indoor air exposure monitoring in a vapor intrusion (VI) environment with trichloroethylene in comparison to the traditional method utilizing a diaphragm flow controller. Traditionally, air sampling with 6 L evacuated canisters equipped with diaphragm flow controllers has been best suited for 8 to 24 h samples. New advances in capillary flow controllers can extend sampling to up to 3 weeks by reducing flow rates to 0.1 milliliters min−1. During six 2 wk sampling events, conventional diaphragm flow controller canisters were used to collect 24 h samples simultaneously with capillary flow controllers collecting 2 wk samples. Testing was performed at four indoor locations in buildings impacted by VI with co-located samples for each method at each location. All samples were analyzed using GC/MS, and the results were statistically analyzed to produce a direct comparison of the two sampling systems. Ninety-two percent of the 14 d capillary samples were within the 95% levels of agreement of the average concentration of the diaphragm flow controllers. The ability to collect 14 days of data, with less occupant disturbance, allows for improved exposure assessments and thus improved risk management decisions.

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Chromatographic Techniques in Industrial Hygiene

Hahne,

LeBouf

2016

Encyclopedia of Analytical Chemistry

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Chromatographic techniques in industrial hygiene are defined as those separation and analysis techniques that rely on the separation of multiple chemical constituents by taking advantage of the differential adsorption, absorption, mobility, or affinity of the components in a system with a stationary phase (solid, liquid coated on solid, reactive substituent attached to solid surface, ion‐exchange resin, etc.) and a mobile phase (gas or liquid) that transports the separated constituents to a detector for immediate identification and possible quantitation or to a collector for later identification and possible quantitation. By industrial (occupational) hygiene is meant that science and art, which is the anticipation, identification, assessment, and control of chemical and physical hazards in the workplace (meant to include offices, places of business, retail establishments, and schools) and home. Included among those methods that make possible the identification and assessment of such hazards are those methods that are used to determine the concentration of airborne and surface chemical contaminants, as well as those that assess levels of exposure to chemical contaminants by the analysis of exhaled breath, blood, urine, or other biological samples.

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Validation of an Evacuated Canister Method for Measuring Part-Per-Billion Levels of Chemical Warfare Agent Simulants

Cited by 7 publications

References 18 publications

Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings

Validation of evacuated canisters for sampling volatile organic compounds in healthcare settings

Evaluation of Long-Term Flow Controller for Monitoring Gases and Vapors in Buildings Impacted by Vapor Intrusion

Chromatographic Techniques in Industrial Hygiene

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