Validation of a quantitative liquid chromatography tandem mass spectrometry assay for linezolid in cerebrospinal fluid and its application to patients with HIV-associated TB-meningitis

Mazanhanga, Marian; Joubert, Anton; Castel, Sandra; Van de Merwe, Marthinus; Maartens, Gary; Wasserman, Sean; Wiesner, Lubbe

doi:10.1016/j.heliyon.2023.e21962

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2024

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“…Furthermore, Davis’s study confirmed the safety of linezolid in TBM treatment [ 15 ]. Currently, the Mazanhanga team has developed a method for measuring the concentration of linezolid in cerebrospinal fluid, thus providing a foundation for monitoring the pharmacokinetics of linezolid in the future [ 16 ]. The utilization of linezolid may represent a significant advancement in the management of TBM, potentially playing a crucial role in limiting the transmission of the disease and reducing mortality rates.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis

Liu,

Tang,

et al. 2024

Arch Med Sci

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IntroductionTuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.MethodsWe searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.ResultsOur findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients.ConclusionsThe analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.

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Section: Discussionmentioning

confidence: 99%