Efficacy of linezolid in the treatment of tuberculous meningitis: a meta-analysis

Abstract

IntroductionTuberculous meningitis (TBM) is a severe extra-pulmonary tuberculosis with high fatality. This meta-analysis aimed to assess the impact of linezolid on TBM treatment outcomes.MethodsWe searched multiple databases for studies published up to May 18, 2024 comparing the effects of linezolid on TBM. Meta-analysis was conducted using Review Manager 5.4.ResultsOur findings indicated that linezolid may reduce treatment failure risk (RR = 0.42 (0.20, 0.89), p = 0.02) and improve temperature recovery (RR = 1.56 (1.21, 2.02), p < 0.001) in TBM patients.ConclusionsThe analysis suggests a positive association between linezolid treatment and therapeutic improvements, with no significant adverse reactions reported.