Validation of a liquid chromatography-tandem mass spectrometry screening method to monitor 58 antibiotics in milk: a qualitative approach

“…With LC‐MS/MS, values of LOQs as low as few µg kg −1 are generally reached; also, the analyses are relatively fast. For instance, 58 antibiotics were analyzed in milk in less than 15 min (Gaugain‐Juhel et al, 2009). However, the selective detection of the triple quadrupole analyzers allows the accurate analysis of incompletely separated compounds.…”

Section: Mass Spectrometry In Foodomicsmentioning

confidence: 99%

Foodomics: MS‐based strategies in modern food science and nutrition

Herrero

Simó

García‐Cañas

et al. 2011

Mass Spectrometry Reviews

338

210

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Modern research in food science and nutrition is moving from classical methodologies to advanced analytical strategies in which MS-based techniques play a crucial role. In this context, Foodomics has been recently defined as a new discipline that studies food and nutrition domains through the application of advanced omics technologies in which MS techniques are considered indispensable. Applications of Foodomics include the genomic, transcriptomic, proteomic, and/or metabolomic study of foods for compound profiling, authenticity, and/or biomarker-detection related to food quality or safety; the development of new transgenic foods, food contaminants, and whole toxicity studies; new investigations on food bioactivity, food effects on human health, etc. This review work does not intend to provide an exhaustive revision of the many works published so far on food analysis using MS techniques. The aim of the present work is to provide an overview of the different MS-based strategies that have been (or can be) applied in the new field of Foodomics, discussing their advantages and drawbacks. Besides, some ideas about the foreseen development and applications of MS-techniques in this new discipline are also provided.

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“…For determination of tetracyclines in biological samples, the first step is to purify the low concentrations of analytes in the samples. Among the reported methods, liquid-liquid extraction (Adrian et al 2012;Gao et al 2013), solid phase extraction (SPE) (Cinquina et al 2003;Cherlet et al 2003;Furusawa 2003;Spisso et al 2007;Gaugain-Juhel et al 2009;Al-Mazeedi et al 2010;Capriotti et al 2012), and molecularly imprinted polymers (Jing et al 2009(Jing et al , 2010Dai et al 2012;Lv et al 2012) are commonly used purification approaches.…”

Section: Introductionmentioning

confidence: 99%

Determination of Tetracyclines in Milk by Graphene-Based Solid-Phase Extraction and High-Performance Liquid Chromatography

Wang

Yang

et al. 2017

Analytical Letters

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A graphene-based solid phase extraction column was prepared for the isolation of tetracyclines from milk followed by determination by high performance liquid chromatography. Graphene provided better separation for tetracyclines than amine modified graphene and carboxyl modified graphene. The optimized graphene-based solid phase extraction column showed high absorption capacities (greater than 4,660 ng) and high recoveries (exceeding 92%) for tetracycline, oxytetracycline, chlortetracycline, and doxycycline and was successfully reused at least fifty times. The limits of detection in milk were from 10 to 20 ng/mL, with recoveries between 82.3 and 103.6%. Furthermore, the system showed superior performance than two commercial solid phase extraction cartridges with respect to recovery, purification, and reusability. Therefore, this approach is suitable for the determination of tetracyclines in milk.

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Validation of a liquid chromatography-tandem mass spectrometry screening method to monitor 58 antibiotics in milk: a qualitative approach

Cited by 73 publications

References 9 publications

Rapid multiresidue and multi-class screening for antibiotics and benzimidazoles in feed by ultra high performance liquid chromatography coupled to tandem mass spectrometry

Rapid multiresidue and multi-class screening for antibiotics and benzimidazoles in feed by ultra high performance liquid chromatography coupled to tandem mass spectrometry

Foodomics: MS‐based strategies in modern food science and nutrition

Determination of Tetracyclines in Milk by Graphene-Based Solid-Phase Extraction and High-Performance Liquid Chromatography

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