Validation of a gas chromatography-electron capture detection of T-2 and HT-2 toxins in Chinese herbal medicines and related products after immunoaffinity column clean-up and pre-column derivatization

Kong, Weijun; Zhang, Xiaofei; Shen, Hong-Hong; Ouyang, Zhen; Yang, Meihua

doi:10.1016/j.foodchem.2011.10.073

Cited by 48 publications

(23 citation statements)

References 15 publications

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“…Positive samples with DON contamination levels were found to range from 17.2 to 50.5 μg kg −1 , which was further confirmed using GC-MS. In 2012, Kong et al [ 188 ] further extended this method for the simultaneous determination of T-2 and HT-2 toxins. Following thorough validation, this was used for the analysis of TCMs and related products from various sources.…”

Section: Analytical Techniques Of Mycotoxinsmentioning

confidence: 99%

A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

Zhang

Dou

Zhang

et al. 2018

Toxins

165

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The presence of mycotoxins in herbal medicines is an established problem throughout the entire world. The sensitive and accurate analysis of mycotoxin in complicated matrices (e.g., herbs) typically involves challenging sample pretreatment procedures and an efficient detection instrument. However, although numerous reviews have been published regarding the occurrence of mycotoxins in herbal medicines, few of them provided a detailed summary of related analytical methods for mycotoxin determination. This review focuses on analytical techniques including sampling, extraction, cleanup, and detection for mycotoxin determination in herbal medicines established within the past ten years. Dedicated sections of this article address the significant developments in sample preparation, and highlight the importance of this procedure in the analytical technology. This review also summarizes conventional chromatographic techniques for mycotoxin qualification or quantitation, as well as recent studies regarding the development and application of screening assays such as enzyme-linked immunosorbent assays, lateral flow immunoassays, aptamer-based lateral flow assays, and cytometric bead arrays. The present work provides a good insight regarding the advanced research that has been done and closes with an indication of future demand for the emerging technologies.

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Section: Analytical Techniques Of Mycotoxinsmentioning

confidence: 99%

A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

Zhang

Dou

Zhang

et al. 2018

Toxins

165

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“…Therefore, we used a further solid-phase extraction clean-up after the sample extraction in order to avoid these ion effects and not to overload the HPLC column. Generally, specific Mycosep or immunoaffinity SPE columns were used in other studies for additional cleaning of sample extracts [6,7,11,15,17]. In this study we tested four reversed-phase (RP) SPE cartridges, namely Strata-XL (6 mL, 200 mg, and 3 mL, 200 mg), Oasis HLB (6 mL, 200 mg) and Strata C-18-U (6 mL, 500 mg) with the above described clean-up procedure (Section 2.2).…”

Section: Optimization Of Sample Preparationmentioning

confidence: 99%

“…T-2 and HT-2 mycotoxins can be separated using both gas and liquid chromatographic (GC and LC) techniques [4][5][6][7]. GC determination involves an addition derivatization step prior to analysis [10][11][12], which extends the analysis time. For LC separation ultraviolet (UV) detection results in high analytical limits and non-selective separation due to the low UV absorbance of these mycotoxins, and consequently, it is not recommended for analysis of complex matrices [4].…”

Section: Introductionmentioning

confidence: 99%

Quantification of T-2 and HT-2 mycotoxins in cereals by liquid chromatography-multimode ionization-tandem mass spectrometry

Tölgyesi

Kunsági

2013

Microchemical Journal

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“…; Kong et al . ). During the outbreak of severe acute respiratory syndrome (SARS) and hemagglutinin type 1 and neuraminidase type 1 (H1N1)‐influenza, banlangen was prescribed as a daily tea to prevent and treat infections in China (Liau et al .…”

Section: Introductionmentioning

confidence: 97%

“…Banlangen tea, made of the roots of Isatis tinctoria L., is a popular functional herbal tea in China (Wu et al 1997;Hamburger 2002;Liau et al 2007;Kong et al 2012). During the outbreak of severe acute respiratory syndrome (SARS) and hemagglutinin type 1 and neuraminidase type 1 (H1N1)-influenza, banlangen was prescribed as a daily tea to prevent and treat infections in China (Liau et al 2007).…”

Section: Introductionmentioning

confidence: 99%

Rapid Detection of Exogenous Adulterants and Species Discrimination for a Chinese Functional Tea (Banlangen) by Fourier‐Transform Near‐Infrared (FT‐NIR) Spectroscopy and Chemometrics

et al. 2015

Journal of Food Quality

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The practical adulterations of herbal tea are usually performed by adding some marker components together with adulterants, or some exogenous adulterants containing the marker components. It is difficult to detect such adulterations by the traditional analytical methods focused on a few marker components. Therefore, Fourier‐transform near‐infrared (FT‐NIR) spectroscopy was used to characterize the compositions and class models of authentic banlangen tea and to detect possible exogenous adulterants. Discrimination of two different species of banlangen tea was also performed using partial least squares discrimination analysis (PLSDA). The most accurate one‐class partial least squares (OCPLS) model was obtained with standard normal variate (SNV) transformation. SNV‐OCPLS could detect adulterations with 5% (w/w) or more dried apple skin in banlangen. For species discrimination, a total classification accuracy of 0.936 was achieved by SNV‐PLSDA. FT‐NIR spectrometry and chemometrics can provide a useful and alternative tool for rapid quality control of banlangen tea. Practical Applications FT‐NIR spectrometry and chemometrics can provide a useful and alternative tool for rapid quality control of banlangen tea.

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Validation of a gas chromatography-electron capture detection of T-2 and HT-2 toxins in Chinese herbal medicines and related products after immunoaffinity column clean-up and pre-column derivatization

Cited by 48 publications

References 15 publications

A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

A Review of Current Methods for Analysis of Mycotoxins in Herbal Medicines

Quantification of T-2 and HT-2 mycotoxins in cereals by liquid chromatography-multimode ionization-tandem mass spectrometry

Rapid Detection of Exogenous Adulterants and Species Discrimination for a Chinese Functional Tea (Banlangen) by Fourier‐Transform Near‐Infrared (FT‐NIR) Spectroscopy and Chemometrics

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