Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems

Bartsch, Helmut; Malaveille, Christian; Camus, Anne-Marie; Martel‐Planche, Ghyslaine; Brun, G; Hautefeuille, A.; Sabadie, N.; Barbin, Alain; Kuroki, Toshio; Drevon, C.; Piccoli, C.; Montesano, Ruggero

doi:10.1016/0165-1110(80)90002-0

Cited by 246 publications

(46 citation statements)

References 63 publications

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“…Therefore, chemical analyses in this study were limited to 16 PAHs, most of them are biologically active [20][21][22][23] or even carcinogenic [6]. The seasonal and spatial pattern of these 16 PAHs was investigated.…”

Section: Discussionmentioning

confidence: 99%

“…Indirect-acting mutagenicity is usually attributed to PAHs [20], since these compounds need metabolic activation in order to exert effect. Next to the indirect-acting compounds other chemicals like nitro-PAHs and oxy-PAHs have direct mutagenic effect and do not need any metabolic activation [38].…”

Section: Discussionmentioning

confidence: 99%

“…It can be assumed that the levels of the nitroderivatives are higher in summer due to increase atmospheric reactions of PAHs with nitrogen oxides [33,39]. [20][21][22][23]. The sum of the concentrations of these 10 indirectacting PAHs correlated quite well with the indirect-acting (+S9) total mutagenic activity (r=0.73, p=0.0004).…”

Section: Discussionmentioning

confidence: 99%

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Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium

Four

Larebeke

Janssen

2004

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium

Four

Larebeke

Janssen

2004

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…Only the highest concentration resulted in a result statistically significantly different from control (1.2-fold increase only). A second experiment was not EFSA Journal 2011; 9(5):1990 (Bartsch et al, 1980) As only two strains were used the quality of the study must be considered insufficient for the purpose of this Flavouring Group Evaluation Validity cannot be evaluated as details of the result were not reported. Negative 17.…”

Section: Annex Iv: Toxicitymentioning

confidence: 99%

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring‐substituted phenolic substances from chemical groups 21 and 25

Flavourings¹

2011

EFS2

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The Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids of the European Food Safety Authority was requested to evaluate 28 flavouring substances in the Flavouring Group Evaluation 22, Revision 1, using the Procedure in Commission Regulation (EC) No 1565/2000. The substance 3,4-methylenedioxyphenol [FL-no: 04.080] was reported to have a genotoxic potential in vitro, while in vivo studies were not available. Therefore, the Panel concluded that the Procedure could not be applied to this substance until adequate genotoxicity data become available. The remaining 27 substances were evaluated through a stepwise approach (the Procedure) that integrates information on structure-activity relationships, intake from current uses, toxicological threshold of concern, and available data on metabolism and toxicity. The Panel concluded that these 27 candidate substances do not give rise to safety concerns at their levels of dietary intake, estimated on the basis of the MSDI approach. Adequate specifications for the materials of commerce are available for all 27 flavouring substances evaluated through the Procedure.

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“…In rats, the activity was low, and hepatic microsomes from hamster showed the highest activity, although there was no appreciable difference between the sexes. Therefore, S-9 mixes obtained from several species are an important factor for the efficient detection of mutagenicityr [8,9].…”

Section: Introductionmentioning

confidence: 99%

Mutagenicity of Analgesics, Their Derivatives, and Anti-inflammatory Drugs with S-9 Mix of Several Animal Species.

Kuboyama

Fujii

1992

The Journal of Nihon University School of Dentistry

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An investigation was undertaken to determine whether analgesics and their derivatives (13 compounds), and anti-inflammatory drugs (4 compounds) had mutagenicity. Rec-assay was used to clarify specific DNA-damaging properties, and the Ames test was used to find back-mutations, using S-9 fractions obtained from the liver of 4 animal species pretreated with polychlorobiphenyl.In the Rec-assay, salicylic acid (2 mg), aspirin (5 mg), benzoic acid (4 mg), sulpyrine (0.4 mg), indomethacin (0.1 mg), oxyphenbutazone (0.1 mg) and diclofenac sodium (0.1 mg) showed a DNA-damaging tendency.In the Ames test, mutagenicity of methyl salicylate was demonstrated using the Salmonella typhimurium TA98 strain upon addition of hamster S-9 mixture. Weak mutagenicity was also found using the TA100 strain with rat S-9 mixture for salicylic acid, sulpyrine, indomethacin and oxyphenbutazone, and with hamster S-9 mixture for methyl salicylate, acetaminophen and phenacetine.

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Validation and comparative studies on 180 chemicals with S. typhimurium strains and V79 Chinese hamster cells in the presence of various metabolizing systems

Cited by 246 publications

References 63 publications

Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium

Genotoxic and mutagenic activity of environmental air samples in Flanders, Belgium

Scientific Opinion on Flavouring Group Evaluation 22, Revision 1 (FGE.22Rev1): Ring‐substituted phenolic substances from chemical groups 21 and 25

Mutagenicity of Analgesics, Their Derivatives, and Anti-inflammatory Drugs with S-9 Mix of Several Animal Species.

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