Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A design of experiments concept for comprehensive method development

With the aim to determine the features of the concentration of C-reactive protein in the blood in carrageenan secondary chronic inflammation on the background of blockade of substance P an experimental prospective controlled randomized study was performed on 132 WAG rats in series of 6 rats each in the natural course and using a pharmacological aprepitant praparationinhibitor of NK-1R in the control and simulated inflammation series for 6 hours, as well as 1, 2, 3, 5, 7, 10, 14, 21, 28 days. the peculiarities of the concentration of C-reactive protein in the blood in carrageenan secondary chronic inflammation on the background of blockade of substance P have been developed.

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Validated mass spectrometric assay for the quantification of substance P and human hemokinin-1 in plasma samples: A design of experiments concept for comprehensive method development

Cited by 2 publications

References 25 publications

Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids

Mass spectrometric studies on the peptide integrity of substance P and related human tachykinins in human biofluids

Dynamics of C-reactive protein in conditions of substance P block

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