Validated HPLC–MS/MS method for determination of quetiapine in human plasma

Barrett, B.; Holčapek, Michal; Huclová, Jitka; Bořek-Dohalský, V.; Fejt, P.; Němec, B.; Jelı́nek, Ivan

doi:10.1016/j.jpba.2007.03.034

Cited by 68 publications

(44 citation statements)

References 10 publications

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“…Sorbents available include C 18 , C 8 , C 2 , phenyl, amino, HLB, polymer, WAX, SAX, WCX and SCX. SPE methods are very popular for the determination of antipsychotics in biological samples Berna et al, 1998;Bogusz et al, 1999;Catlow et al, 1995;Lara et al, 2005;Olesen and Poulsen, 1993;Gupta, 1995;Barrett et al, 2007;Josefsson et al, 2003;Frahnert et al, 2003;Mercolini et al, 2007;Hasselstrom and Linnet, 2003). Remmerie et al (2003) used LC-MS/MS method for the determination of RISP and 9-OH RISP in human plasma using a mixed-mode phase SPE cartridge (Bond Elut Certify).…”

Section: Solid-phase Extractionmentioning

confidence: 99%

“…The selection of specific analyte ion(s) with the first quadrupole and diagnostic abundant fragment ion(s) with the third quadrupole results in a technique called multiple reaction monitoring. Many sensitive GC-MS, LC-MS or LC-MS/MS methods for bioanalysis of antipsychotics have been published (Niederländer et al, 2006;Zhang et al, 2007a,b,d;Janiszewski et al, 1997;Al-Dirbashi et al, 2006;Aravagiri and Marder, 2000;Aravagiri et al, 2007;Lin et al, 2004;Barrett et al, 2007;Kubo et al, 2005;Josefsson et al, 2003;Kollroser and Schober, 2002;Zhou et al, 2004;Kirchherr and Kuhn-Velten, 2006;Li et al, 2007;Remmerie et al, 2003;Bhatt et al, 2006;Flarakos et al, 2004;Berna et al, 1998Berna et al, , 2002Bogusz et al, 1999;Gervasini et al, 2003;Nirogi et al, 2006;Hattori et al, 1986;Arinobu et al, 2002;McKay et al, 1982). Zhang et al (2005) described a LC-MS method for the quantitation of RISP and 9-OH RISP in human plasma.…”

Section: Mass Spectrometersmentioning

confidence: 99%

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Bioanalytical methods for the determination of antipsychotic drugs

Zhang

Terry

Bartlett

2008

Biomedical Chromatography

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Antipsychotic drugs are popular for the treatment of schizophrenia and other psychoses. In general, antipsychotics are administered in oral doses of only a few milligrams per day and they are widely metabolized in the body. Therefore, the concentration of these drugs in plasma is very low (pg-ng/mL levels). In addition, therapeutic drug monitoring (TDM) of antipsychotic drugs has proven to be of notable value for determining poor compliance of patients and addressing the challenges associated with considerable genetic variability in their metabolism. Thus, in order to conduct pharmacology and toxicology studies and clinical TDM of antipsychotics, as well as address the challenges associated with polypharmacy and drug metabolism, highly sensitive, selective and accurate bioanalytical methods are essential. The most recent studies on the determination of antipsychotics will be reviewed, including separation techniques, sample pretreatment, detectors and validation.

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Section: Solid-phase Extractionmentioning

confidence: 99%

Section: Mass Spectrometersmentioning

confidence: 99%

Bioanalytical methods for the determination of antipsychotic drugs

Zhang

Terry

Bartlett

2008

Biomedical Chromatography

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“…5 QTF is not official in any pharmacopoeia. Several analytical methods such as HPLC, [6][7][8][9][10][11][12][13] chemiluminescence spectrometry, 14 electrospray ionization MS, [15][16][17][18] tandem MS/MS detection, [19][20][21][22] UPLC with tandem MS detection, 23,24 GC 25,26 and voltammetry 27 are found in the literature for the determination of QTF in biological materials.…”

Section: Introductionmentioning

confidence: 99%

Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Rajendraprasad¹,

Basavaiah²,

Vinay³

2012

Croat. Chem. Acta

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A simple, sensitive and selective extractive spectrophotometric method for the determination of quetiapine fumarate (QTF) in bulk drug, tablets and spiked human urine sample is described. The method is based on the formation of a chloroform extractable yellow ion-pair complex between basic nitrogen of the drug (QTF) and the dye quinoline yellow (QY) in acetate-hydrochloride buffer (pH 2.56) medium. The formed ion-pair complex exhibited an absorption maximum at 420 nm. Beer's law is obeyed over the concentration range 2.5-25 µg mL -1 with an apparent molar absorptivity value of 2.02 × 10 4 L mol -1 cm -1 . The Sandell sensitivity, limits of detection (LOD) and quantification values are also reported. The composition of the ion-pair was established by Job's continuous variations method and it was found to be 1:1 (QTF:QY). The proposed method was successfully applied for the determination of QTF in bulk drug, tablets and spiked human urine without any interference. (doi: 10.5562/cca1770)

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“…Recently few LC-MS/MS methods have been reported for quantification of quetiapine (Barrett et al, 2007;Hasselstrom and Linnet, 2003;Li et al, 2004;Lin et al, 2004;Zhou et al, 2004). Zhou et al (2004) reported an LC-MS/MS method for simultaneous determination of clozapine, olanzapine, risperidone and quetiapine in 0.5 mL plasma with an lower limit of quantification (LLOQ) of 20 ng/ mL.…”

Section: Introductionmentioning

confidence: 99%

Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma

Nirogi

Bhyrapuneni

Kandikere

et al. 2008

Biomedical Chromatography

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A sensitive high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of quetiapine in rat plasma. Following liquid-liquid extraction, the analyte was separated using a gradient mobile phase on a reverse-phase column and analyzed by MS/MS in the multiple reaction monitoring mode using the respective [M + H]+ ions, m/z 384 to m/z 221 for quetiapine and m/z 327 to m/z 270 for the internal standard. The assay exhibited a linear dynamic range of 0.25-500 ng/mL for quetiapine in rat plasma. The lower limit of quantification was 0.25 ng/mL with a relative standard deviation of less than 7%. Acceptable precision and accuracy were obtained for concentrations over the standard curve range. The validated method was successfully used to analyze rat plasma samples for application in pre-clinical pharmacokinetic studies. This method in rodent plasma could be adapted for quetiapine assay in human plasma.

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Validated HPLC–MS/MS method for determination of quetiapine in human plasma

Cited by 68 publications

References 10 publications

Bioanalytical methods for the determination of antipsychotic drugs

Bioanalytical methods for the determination of antipsychotic drugs

Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma

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