Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Rajendraprasad, N.; Basavaiah, K.; Vinay, K. B.

doi:10.5562/cca1770

Cited by 20 publications

(14 citation statements)

References 24 publications

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“…The oxidation reactions of some compounds are very rapid when perchloric acid (HClO 4 ) medium is maintained. [5][6][7][8] This is attributed to the highest oxidation potential of cerium(IV) in HClO 4 (E o D 1.75V) as compared to that of cerium(IV) in H 2 SO 4 (E o D 1.44), HNO 3 (E o D 1.61V) or HCl (E o D1.28V). [9] In sulfuric acid and sulfate media, cerium(IV) forms several sulfato complexes.…”

Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Jattinagoudar

Byadagi

Nandibewoor

et al. 2015

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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The kinetics of the oxidation of fosfomycin disodium salt by cerium(IV) in an aqueous perchloric acid medium at constant ionic strength, I D 1.10 mol dm ¡3 , has been investigated spectrophotometrically at 25 C. The reaction is of first order in cerium(IV) concentration, fractional order in both fosfomycin and H C ion concentrations. The active species of oxidant is found to be Ce (OH) 3C . Based on the experimental results a suitable mechanism is proposed. The reaction constants involved in the different steps of the reaction mechanism and the activation parameters with respect to the slow step of the mechanism are determined and discussed.

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Section: Introductionmentioning

confidence: 99%

Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Jattinagoudar

Byadagi

Nandibewoor

et al. 2015

Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-

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“…Quetiapine fumarate is not official in any pharmacopoeia 2 . Literature survey reveals that LC-MS/MS 3 , LC-Electrospray-Tandem Mass Spectroscopy 4 , HPLC 5 methods have been reported for determination of QTF in human plasma.…”

Section: Quick Response Codementioning

confidence: 99%

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2018

IJPSR

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A new, simple, sensitive, accurate and precise RP-HPLC method was developed for the estimation of quetiapine fumarate in human plasma. Full factorial design was used for the optimization of an extraction method. The main effect of volume of deproteinating agent, speed of centrifugation, time of centrifugation and temperature of centrifugation was found to be significant at P<0.0001 on all the responses. After deproteinization, the drug was analyzed on a C18 (150 × 4.6mm, 5 µm) column using UV detector. The mobile phase consisting acetonitrile and phosphate buffer (pH 3) in the ratio of 50:50 (v/v) at a flow rate of 1.0 ml/min. The standard calibration curve was constructed in the concentration range of 5 µg/ml to 30 µg/ml and linearity was found to be 0.999. Irbesartan was used as the internal standard. The retention time of quetiapine fumarate and the internal standard was found to be 5.42 and 2.89 min, respectively. No interference peak was perceived. The high performance liquid chromatography method was successfully demonstrated as rapid and sensitive method which can be used as an alternative for the analysis of quetiapine fumarate in plasma samples.

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“…A variety of analytical techniques such as high-performance liquid chromatography [4][5][6][7][8], gas chromatography [9], thin layer chromatography [10], micellar liquid chromatography [11], capillary zone electrophoresis [3], voltammetry [12], LC-MS [13], potentiometry [14,15], gravimetry [16] and titrimetry [17][18][19][20][21][22] have been reported for the determination of HDH in biological fluids and pharmaceuticals. The official USP method available for the assay of the drug in tablets employs a chromatographic system equipped with a UV-detector, where HDH can be detected at 232 nm [23].…”

Section: Introductionmentioning

confidence: 99%

Sensitive and Selective Extractive Spectrophotometric Method for the Determination of Hydroxyzine Dihydrochloride in Pharmaceuticals

et al. 2019

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Hydroxyzine dihydrochloride (HDH), a piperazine H1-receptor antagonist and antihistamine, is a rapid acting anxiolytic used principally as an anti-emetic. A sensitive, selective, and precise and accurate spectrophotometric method based on the formation of an ion-pair with orange II (ORG II) as ion-pair complexing agent was developed and validated for the determination of HDH in pharmaceuticals. The chloroform-extractable ion-pair complex exhibited an absorption maximum at 480 nm. Optimization of different experimental conditions is described. Beer’s law is obeyed in the range of 1.5-15 μg mL-1 with an apparent molar absorptivity value of 2.07 x 104 L mol-1 cm-1 and Sandell’s sensitivity value of 0.0216 μg cm-2. The limit of detection (LOD) and limit of quantification (LOQ) are 0.14 and 0.41 μg mL-1, respectively. A Job’s plot of absorbance versus molar ratio of HDH to ORG II indicated (1:2) stoichiometric ratio. Within- and between-day relative standard deviations at three different concentration levels were < 3%. The developed method was successfully applied to commercial tablets. The results obtained were in good agreement with those obtained using the official method. No interference was encountered from co-formulated substances. Recoveries were 96-109 %.

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Extractive Spectrophotometric Determination of Quetiapine Fumarate in Pharmaceuticals and Spiked Human Urine

Cited by 20 publications

References 24 publications

Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

Kinetics and Mechanism of Cerium(IV) Oxidation of Fosfomycin Disodium Salt: An Antibiotic Drug in Acid Perchlorate Solutions

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Sensitive and Selective Extractive Spectrophotometric Method for the Determination of Hydroxyzine Dihydrochloride in Pharmaceuticals

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