Validated determination of losartan and valsartan in human plasma by stir bar sorptive extraction based on acrylate monolithic polymer, liquid chromatographic analysis and experimental design methodology

A Comprehensive Review on Developed Pharmaceutical Analysis Methods by Iranian Analysts in 2018

“…Ghani et al 96 reported a HPLC-UV method for determination of diclofenac in urine and plasma samples after its microextraction by a Mg-Al-layered double hydroxide (LDH)-GO mixed-matrix membrane. Similar works were performed for determination of L-cysteine in spiked plasma and urine samples after extraction by using zinc organic polymer (Zn-MOP) as a sorbent, 97 for simultaneous determination of losartan and valsartan in spiked plasma samples after extraction with stir bar sorptive extraction (SBSE) based on acrylate monolithic polymer, 98 for determination of vincristine in spiked plasma and urine samples by using a solvent bar microextraction (SBME) with water at pH 10.7 as donor phase, 1-octanol as the supported liquid membrane and an aqueous receiving phase (pH =3.1), 99 for simultaneous determination of oxazepam, flurazepam, and diazepam in hair, nail and blood samples after extraction by using a vortex assisted dispersive solid phase extraction approach based on crab shell powder as micro-sorbent, 100 for determination of rizatriptan in spiked plasma and urine samples after extraction by using SBME technique, 101 for determination of diclofenac, ibuprofen, and mefenamic acid in spiked plasma and urine samples after extraction with centrifugeless ultrasoundassisted dispersive micro solid-phase extraction with Zn-Al-LDH-MWCNT nanohybrid as a nanosorbent coupled with salting-out ultrasound-assisted liquid-liquid microextraction based on solidification of a floating organic droplet, 102 for determination of zolpidem in spiked plasma and serum samples after an EME procedure, 103 for determination of phenazopyridine after a extraction procedure by coupling EME and packing a sorbent (a cation exchanger) with reported value of 33 µg L -1 and 237.3 µg L -1 for phenazopyridine in urine sample of patients treated with it respectively after 9 and 12 hour, 104 for determination of diclofenac in spiked plasma and urine samples after extraction by HF-LPME, 105 for determination of valproic acid in spiked plasma samples after extraction by using HF-EME method, 106 and for determination of exemestane, letrozole and paclitaxel in spiked urine samples after extraction by using three-phase HF-LPME based on two immiscible organic solvents (acetonitrile and n-dodecane). 107 Magnetic solid phase extraction (MSPE) as an alternative method for SPE have mostly been used for sample preparation before HPLC-UV.…”

Interpol review of toxicology 2016–2019

“…Determination of dimethyl trisulfide in rabbit blood [ 471 ], Ghrelin hormone (aka. hunger hormone) [ 472 ], losartan and valsartan in human plasma [ 473 ] were reported by different research groups. The aforementioned examples made use of commercially available stir bars.…”

Modern Approaches to Preparation of Body Fluids for Determination of Bioactive Compounds

“…Taking into account the time of sample preparation (3 h), low cost of each coated bar, and possibility to reuse it 50 times, the authors recommended the proposed method as a reliable tool for routine analysis. Novel coatings for bars in the SBSE approach were introduced for body fluid preparation for the determination of antihypertensive drugs [50] and illicit drugs [51]. A monolithic vinylpyrroli-doneethylene glycol dimethacrylate (VPD-EDMA) polymer was applied to the extraction of losartan and valsartan from plasma samples [50].…”

“…Novel coatings for bars in the SBSE approach were introduced for body fluid preparation for the determination of antihypertensive drugs [50] and illicit drugs [51]. A monolithic vinylpyrroli-doneethylene glycol dimethacrylate (VPD-EDMA) polymer was applied to the extraction of losartan and valsartan from plasma samples [50]. Compared to commercially available PDMS (polydimethylsiloxane) and PA (polyacrylamide) stir bars, the proposed coated stir bar exhibited higher physical stability and, therefore, it was suitable for the use of an ultrasonic stirring mode, which was profitable in terms of requiring less time and less solvent for the performed extraction.…”