Dermatologic surgery, including cancer surgery, cosmetic surgery, and laser and energy device procedures, is a well-established branch of dermatology known for minimally invasive, effective, and safe solutions to patient problems. Over time, clinical research pertaining to dermatologic surgery has improved in terms of methodologic rigor, with dermatologic surgery accounting for a large proportion of the comparative effectiveness studies and randomized controlled trials in dermatology. Further improvements in the quality of studies examining dermatologic surgery therapies will require understanding and overcoming several remaining challenges.