Validated 1H and 13C Nuclear Magnetic Resonance Methods for the Quantitative Determination of Glycerol in Drug Injections

Jiang, Lu; Wang, Pengli; Wang, Qiuying; Wang, Yanan; Jiang, Miaomiao

doi:10.3390/molecules23051177

Cited by 11 publications

(5 citation statements)

References 18 publications

(17 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…50 The sharp peak at 3.5 ppm is related to the glycerol (1-CH 2 , 3-CH 2 groups). 51 This further conforms that the byproducts of the degradable materials showed pectin and glycerol compounds. The sharp signal at 4.67 ppm is assigned to the D 2 O solvent.…”

Section: Nanoscale Papersupporting

confidence: 83%

Eco-friendly pectin polymer film-based triboelectric nanogenerator for energy scavenging

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Nanoscale Papersupporting

confidence: 83%

Eco-friendly pectin polymer film-based triboelectric nanogenerator for energy scavenging

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The seventeen known isolates of G. theophrastifolium were identified by comparison of their spectroscopic data with those reported in the literature for chondrosterin G ( 3 ), [20] 1,2‐ O ‐isopropylidene‐ β ‐D‐fructopyranose ( 4 ), [28] 1,2 : 4,5‐Di‐ O ‐isopropylidene‐ β ‐D‐fructopyranose ( 5 ), [28] glycerol ( 6 ), [29] and 1‐ O ‐hex‐3‐enyl β ‐D‐glucopyranosyl ( 7 ), [30] 1‐ O ‐benzyl β ‐D‐glucopyranoside ( 8 ), [31] pinoresinol ( 9 ), [32] Balanophonin B ( 10 ), [33] syringaresinol ( 11 ), [34] (−)‐glaberide I ( 12 ), [35] 4‐hydroxybenzoic acid ( 13 ), [36] methyl 4‐hydroxybenzoate ( 14 ), [37] apigenin ( 15 ), [38] luteolin ( 16 ), [39] diosmetin ( 17 ), [40] lutein ( 18 ), [41] and β ‐sitosterol‐3‐ O ‐ β ‐D‐glucopyranoside‐6′‐ O ‐palmitate ( 19 ) [38] ( Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Elemane‐Type Sesquiterpene, Acetonide Derived Polyacetylene and Other Constituents from the Whole Plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. and Their Chemophenetic Significance

Tsakou

Ndontsa

Nono

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

The chemical investigation of the methanol extract of the whole plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. (Asteraceae) led to the isolation of a new elemane-type sesquiterpene (1), a new acetonide derived polyacetylene (2) and a naturally occurring compound (3) from the plant kingdom along with sixteen known compounds (4 -19). Their structures were elucidated by extensive NMR and MS analysis. This is the first report on the chemical constituents of G. theophrastifolium. Furthermore, compounds 12, 13, and 14 are reported for the first time from the family Asteraceae, while compound 9 is reported for the first time from the genus Gymnanthemum. Thus, the present results provide valuable insights to the chemophenetic knowledge of G. theophrastifolium, which is also discussed in this work.

show abstract

“…The spectrum without the saturation transfer from the protein was obtained for Zuogui-CSS ( Figure 8A ). In the STD difference spectrum (the upper spectrum in Figure 8B ), the only observed peaks were those from glycerol (3.54, 3.63, and 3.77 ppm) and H 2 O (4.70 ppm) in the solution ( Lu et al, 2018 ). These were nonspecific peaks due to their high concentrations as they also were present in the spectrum without the protein (lower spectrum in Figure 8B ).…”

Section: Resultsmentioning

confidence: 99%

An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

Lan

Liang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Ethnopharmacological relevance: Two types of traditional Chinese formulas of botanical drugs are prescribed for treating perimenopausal syndrome (PMS), a disorder in middle-aged women during their transition to menopause. One is for treating PMS as kidney deficiency (KD) due to senescence and declining reproductive functions, and the other is for treating it as liver qi stagnation (LQS) in association with stress and anxiety. Despite the time-tested prescriptions, an objective attestation to the effectiveness of the traditional Chinese treatment of PMS is still to be established and the associated molecular mechanism is still to be investigated.Materials and methods: A model for PMS was generated from perimenopausal rats with chronic restraint stress (CRS). The effectiveness of traditional Chinese formulas of botanical drugs and a combination of two of the formulas was evaluated based on 1H NMR plasma metabolomic, as well as behavioral and physiological, indicators. To investigate whether the formulas contained ligands that could compensate for the declining level of estrogen, the primary cause of PMS, the ligand-based NMR technique of saturation transfer difference (STD) was employed to detect possible interacting molecules to estrogen receptors in the decoction.Results: Each prescription of the classical Chinese formula moderately attenuated the metabolomic state of the disease model. The best treatment strategy however was to combine two traditional Chinese formulas, each for a different etiology, to adjust the metabolomic state of the disease model to that of rats at a much younger age. In addition, this attenuation of the metabolomics of the disease model was by neither upregulating the estrogen level nor supplementing an estrogenic compound.Conclusion: Treatment of PMS with a traditional Chinese formula of botanical drugs targeting one of the two causes separately could ameliorate the disorder moderately. However, the best outcome was to treat the two causes simultaneously with a decoction that combined ingredients from two traditional prescriptions. The data also implicated a new paradigm for phytotherapy of PMS as the prescribed decoctions contained no interacting compound to modulate the activity of estrogen receptors, in contrast to the treatment strategy of hormone replacement therapy.

show abstract

Validated 1H and 13C Nuclear Magnetic Resonance Methods for the Quantitative Determination of Glycerol in Drug Injections

Cited by 11 publications

References 18 publications

Eco-friendly pectin polymer film-based triboelectric nanogenerator for energy scavenging

Eco-friendly pectin polymer film-based triboelectric nanogenerator for energy scavenging

Elemane‐Type Sesquiterpene, Acetonide Derived Polyacetylene and Other Constituents from the Whole Plant of Gymnanthemum theophrastifolium (Schweinf. ex Oliv. & Hiern) H.Rob. and Their Chemophenetic Significance

An Effective Treatment of Perimenopausal Syndrome by Combining Two Traditional Prescriptions of Chinese Botanical Drugs

Contact Info

Product

Resources

About