Valeur de l’éosinopénie dans le diagnostic des syndromes inflammatoires : un « vieux » marqueur revisité

Gil, H.; Magy, N.; Mauny, Frédéric; Dupond, J.L.

doi:10.1016/s0248-8663(03)00138-3

Cited by 68 publications

(20 citation statements)

References 14 publications

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“…In fact, eosinophil numbers typically decrease in response to bacterial infection in both humans 69 and mice 70 . However, eosinophils have been shown to promote defense in murine models against some bacteria, such as Pseudomonas aeruginosa 71 .…”

Section: Role In Host Defensementioning

confidence: 99%

Eosinophils in mucosal immune responses

2015

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Eosinophils, multifunctional cells that contribute to both innate and adaptive immunity, are involved in the initiation, propagation and resolution of immune responses, including tissue repair. They achieve this multifunctionality by expression of a diverse set of activation receptors, including those that directly recognize pathogens and opsonized targets, and by their ability to store and release preformed cytotoxic mediators that participate in host defense, to produce a variety of de novo pleotropic mediators and cytokines and to interact directly and indirectly with diverse cell types, including adaptive and innate immunocytes and structural cells. Herein, we review the basic biology of eosinophils and then focus on new emerging concepts about their role in mucosal immune homeostasis, particularly maintenance of intestinal IgA. We review emerging data about their development and regulation and describe new concepts concerning mucosal eosinophilic diseases. We describe recently developed therapeutic strategies to modify eosinophil levels and function and provide collective insight about the beneficial and detrimental functions of these enigmatic cells.

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Section: Role In Host Defensementioning

confidence: 99%

Eosinophils in mucosal immune responses

2015

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“…In 2003 Gil et al [6] showed that eosinophil count was a marker of infection, demonstrating that a leukocyte count of above 10,000/mm 3 and an eosinophil count of below 40/mm 3 were strongly related to the presence of bacterial infections.…”

Section: Introductionmentioning

confidence: 99%

Eosinophil Count and Neutrophil-Lymphocyte Count Ratio as Prognostic Markers in Patients with Bacteremia: A Retrospective Cohort Study

et al. 2012

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IntroductionThere is scarce evidence on the use of eosinophil count as a marker of outcome in patients with infection. The aim of this study was to evaluate whether changes in eosinophil count, as well as the neutrophil-lymphocyte count ratio (NLCR), could be used as clinical markers of outcome in patients with bacteremia.MethodsWe performed a retrospective study of patients with a first episode of community-acquired or healthcare-related bacteremia during hospital admission between 2004 and 2009. A total of 2,311 patients were included. Cox regression was used to analyze the behaviour of eosinophil count and the NLCR in survivors and non-survivors.ResultsIn the adjusted analysis, the main independent risk factor for mortality was persistence of an eosinophil count below 0.0454·103/uL (HR = 4.20; 95% CI 2.66–6.62). An NLCR value >7 was also an independent risk factor but was of lesser importance. The mean eosinophil count in survivors showed a tendency to increase rapidly and to achieve normal values between the second and third day. In these patients, the NLCR was <7 between the second and third day.ConclusionBoth sustained eosinopenia and persistence of an NLCR >7 were independent markers of mortality in patients with bacteremia.

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“…The relatively lower eosinophil counts seen among the infected patients was interpreted to be a reflection of the inflammatory response to TB, which was consistent with the considerably higher ESR values seen among the infected patients. Even though eosinopenia was typically associated with acute inflammations and acute phase reactions due to acute bacterial infections, our findings would suggest that chronic inflammations due to TB could also cause eosinopenia 20,21. However, mildly elevated ESRs were also found among our uninfected patients.…”

Section: Discussionmentioning

confidence: 50%

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

Ahmed

Bukar²,

Jolayemi³

2010

Mediterr J Hematol Infect Dis

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Nigeria has the fourth highest prevalence of TB and the highest prevalence of Sickle cell anaemia (SCA) in the world. SCA patients have impaired immunity and are vulnerable to TB. Hence, we studied the haematological indices of SCA patients with TB in Nigeria. A total of 23 SCA patients with TB were studied in parallel with equal number of age and sex matched SCA patients without TB. SCA patients with TB had significantly lower haematocrit, higher level of circulating sickle cells (CSCs) and similar level of reticulocyte count in comparison to patients without TB. SCA patients with TB had significantly higher mean WBC count associated with higher frequency of neutrophilia in comparison to those without TB. Monocytosis and eosinopenia were exclusively found in SCA patients with TB at frequencies of 52% and 65% respectively. Lymphocyte and basophil counts were normal in all patients with and without TB. Mean platelet counts were high in both patient groups but the frequency of thrombocytosis was significantly higher in patients with TB. SCA patients with TB had significantly higher mean ESR than their counterparts without the infection. The findings of this study revealed that TB in SCA patients was associated with rising level of CSCs, falling level of haematocrit, sub-optimal reticulocytosis, neutrophilia, monocytosis, thrombocytosis, eosinopenia and rising level of ESR. Hence, SCA patients presenting with these haematological indices should be investigated for TB.

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Valeur de l’éosinopénie dans le diagnostic des syndromes inflammatoires : un « vieux » marqueur revisité

Cited by 68 publications

References 14 publications

Eosinophils in mucosal immune responses

Eosinophils in mucosal immune responses

Eosinophil Count and Neutrophil-Lymphocyte Count Ratio as Prognostic Markers in Patients with Bacteremia: A Retrospective Cohort Study

Hematological Indices of Sickle Cell Anaemia Patients with Pulmonary Tuberculosis in Northern Nigeria.

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