Eosinophil Count and Neutrophil-Lymphocyte Count Ratio as Prognostic Markers in Patients with Bacteremia: A Retrospective Cohort Study

Terradas, Roser; Grau, Santiago; Blanch, Jordi; Riu, Marta; Saballs, Pere; Castells, Xavier; Horcajada, Juan Pablo; Knobel, Hernando

doi:10.1371/journal.pone.0042860

Cited by 154 publications

(143 citation statements)

References 32 publications

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“…Again, numerous studies suggested that NLR is an important criterion in making diagnostic and prognostic decisions in psoriasis, infective endocarditis, pneumonia, bacteremia and acute appendicitis. [13][14][15][16][17] In our study, we found that lymphocyte was higher in the patient group than the control group, and as a result, NLR was significant. This result supports the cause of chronic inflammation which plays an etiologic role in children with LAP.…”

Section: Discussionmentioning

confidence: 91%

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Sarıca¹,

Bilal²,

Orhan³

et al. 2017

ENT Updates

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Lymphadenopathies constitute most of the neck masses of the children. Lymph nodes are arranged along the lymphatic canal. They are rich in lymphocytes and antigenpresenting cells and surrounded by a fibrous capsule. Lymph node enlargement in local and systemic infectious cases is seen as lymphadenomegaly or lymphadenopathy Yöntem: Muayene s›ras›nda saptanan herhangi bir neden olmaks›z›n boyunda fliflme flikayetiyle 2014 ile 2017 y›llar› aras›nda KBB klini¤i-ne kabul edilen ve idiyopatik patolojik LAP tan›s› konulan toplam 100 çocuk retrospektif çal›flmaya dahil edildi. Kontrol grubu herhangi bir enfeksiyonu olmayan ve muayene ve laboratuvar tahlillerine göre sa¤-l›kl› oldu¤u düflünülen 100 çocuktan oluflmaktayd›. Hastalar ve kontrol grubu klinikteki hasta kay›tlar›na bak›larak yafl, cinsiyet, klinik öykü, hastal›k süreci ve muayene bulgular› aç›s›ndan tarand›. Bulgular:Hasta grubunda ortalama lökosit ve lenfosit say›lar› kontrol grubundan daha yüksek olup farkl›l›k istatistiksel olarak anlaml›yd› (s›ra-s›yla p=0.008 ve p=0.001). Hasta grubunda ortalama NLO ve TLO de¤erleri kontrol grubuna göre anlaml› derecede daha düflüktü (s›ras›yla p=0.009 ve p=0.020). Sonuç:Bilinmeyen etiyolojili patolojik servikal LAP nedeniyle takip edilen çocuklarda NLO ve TLO enflamasyonla iyi bir korelasyon gös-terebilir.Anahtar sözcükler: Nötrofil/lenfosit orant›s›, trombosit/lenfosit orant›s›, lenfadenopati. AbstractObjective: To reveal whether if neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) rates are useful or not in children followed-up due to pathological cervical lymphadenopathy (LAP) of unknown etiology who have a normal hematologic examination. Methods:A total of 100 children admitted to the otorhinolaryngology clinic between 2014 and 2017 with the complaint of swelling in the neck without any etiology revealed on examination and established with the diagnosis of idiopathic pathological LAP were retrospectively included in the study. The control group consisted of 100 children who did not have any infectious condition and could be considered healthy in terms of examination and laboratory findings. Patients' and the control group's age, gender, clinical history, disease course and examination findings were screened from the patients' records in the clinic. Results:Mean white blood cell and lymphocyte count parameters in the patient group were higher than the control group, and the difference was statistically significant (p=0.008 and p=0.001, respectively). In the patient group, mean NLR and PLR values were significantly lower than the control group (p=0.009 and p=0.020, respectively).Conclusion: NLR and PLR rates may be well correlated with inflammation in children followed-up due to pathologic cervical LAP with unknown etiology.

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Section: Discussionmentioning

confidence: 91%

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Sarıca¹,

Bilal²,

Orhan³

et al. 2017

ENT Updates

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“…Study from Netherlands reported that NLR >10 has 77.2% sensitivity and 63% specificity for predicting bacteremia 6 . Interestingly, another study reported that NLR with cut off >7 can be used as a prognostic marker in patients with bacteremia sepsis and in that study the NLR >7 was an independent risk factor for mortality in sepsis patients with bacteremia 18 . Acute physiology and chronic health evaluation (APACHE) II scoring system is designed to measure the severity of disease in patients admitted to the intensive care unit.…”

Section: Discussionmentioning

confidence: 96%

Comparison of Neutrophils-lymphocytes Ratio and Procalcitonin Parameters in Sepsis Patient Treated in Intensive Care Unit Dr. Wahidin Hospital, Makassar, Indonesia

Arif¹,

Rukka²,

Wahyuni³

2016

J. of Medical Sciences

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Neutrophils-lymphocytes ratio (NLR) is regarded as a cheap, simple and promising parameter to predict sepsis severity. This study was aimed to compare NLR and procalcitonin (PCT) parameters and its correlation with acute physiology and chronic health evaluation (APACHE) II scoring system in sepsis and severe patients. This retrospective study investigated 65 sepsis patients data in the medical record that been treated in Intensive Care Unit (ICU) in the last 2015 at Dr. Wahidin Sudirohusodo Hospital Makassar. Data collected including neutrophil, lymphocytes, PCT and the APACHE II score. Based on clinical finding and the dependency to vasopressor, the patients were divided into sepsis and severe sepsis groups. The NLR, PCT and APACHE II scores in sepsis and severe sepsis were compared, the cut off point for NLR and PCT were determined and the sensitivity and specificity were calculated. Procalcitonin level was significantly different in sepsis and severe sepsis groups (p<0.001), the difference was not seen for NLR. The Cut off Point (COP) to distinguish between sepsis and severe sepsis for NLR was 9.05 with sensitivity and specificity 59.6 and 50.0%, respectively. For PCT it was 2.89 with sensitivity and specificity 98.2 and 75.0%, respectively. There was a significant positive correlation between APACHE II score with NLR (p = 0.036) and with PCT (p = 0.027). Procalcitoninis superior than NLR in distinguishing sepsis and severe sepsis, however, since a positive correlation found between APACHE II score with NLR and with PCT, NLR can be used as parameter to predict the severity of sepsis in the hospital with limited laboratory facilities.

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“…18 Some studies showed that NLR is promising marker in predicting bacteremia in patients with emergency medical admissions. [19][20][21] NLR was used as prognostic marker in patient with bacteremia. 20 We aimed to investigate whether NLR is a predictor of AKI in patients with septic shock.…”

Section: Introductionmentioning

confidence: 99%

Can neutrophil–lymphocyte ratio be independent risk factor for predicting acute kidney injury in patients with severe sepsis?

Yılmaz

Çakmak

İnan³

et al. 2014

Renal Failure

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Aim: Neutrophil-lymphocyte ratio (NLR) is an easily calculated, sensitive, and accurate marker for prognosis and diagnosing sepsis, cardiovascular disease and cancer. As sepsis and septic shock are main causes of acute kidney injury (AKI) intensive care unit (ICU), we investigated whether NLR is an early predictor of AKI in patients with severe sepsis. We compared NLR's predictive power with that of other inflammation-related variables. Methods: Between December 2011 and November 2013, we enrolled 118 consecutive cases with severe sepsis admitted to ICU in this retrospective study. Levels of C-reactive protein (CRP), NLR, and white blood cell count (WBC) were recorded on admission and patients' renal function was monitored for seven consecutive days. Results: The rate of AKI occurrence 7 days after enrollment was 57.6%. NLR levels were higher in the AKI group (Group 1) than in the non-AKI group (Group 2) on the day of ICU admission (p50.001). AKI development was independently associated with NLR, Acute Physiology and Chronic Health Evaluation II (APACHE II) and duration of invasive mechanical ventilation (MV) in multivariate logistic regression analysis. The area under the receiver-operating characteristic (ROC) curve of NLR for predicting AKI was 0.986, which was superior to WBC and CRP (p50.05). The cut-off value of 10.15 for NLR had the highest validity for predicting AKI in patients with severe sepsis. The sensitivity, specificity, negative-predictive value (NPV), and positive-predictive value (PPV), for this cut-off value was 90.2%, 92.9%, 90.4%, and 92.7%, respectively. Conclusion: NLR is superior to CRP, and WBC for predicting the development of AKI in patients with severe sepsis.

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Eosinophil Count and Neutrophil-Lymphocyte Count Ratio as Prognostic Markers in Patients with Bacteremia: A Retrospective Cohort Study

Cited by 154 publications

References 32 publications

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

The investigation of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio in children with pathological cervical lymphadenopathy

Comparison of Neutrophils-lymphocytes Ratio and Procalcitonin Parameters in Sepsis Patient Treated in Intensive Care Unit Dr. Wahidin Hospital, Makassar, Indonesia

Can neutrophil–lymphocyte ratio be independent risk factor for predicting acute kidney injury in patients with severe sepsis?

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