Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Shinjyo, Noriko; Waddell, Guy; Green, Julia

doi:10.1177/2515690x20967323

Cited by 90 publications

(80 citation statements)

References 154 publications

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“…[308]. Valerian preparations have further been shown to encourage sleep, improve sleep quality, and reduce blood pressure [309]. Additionally, the root is known for its mild anodyne, hypnotic, carminative, and hypotensive properties [301].…”

Section: Valeriana Officinalismentioning

confidence: 99%

“…Additionally, the root is known for its mild anodyne, hypnotic, carminative, and hypotensive properties [301]. Sleep promotion and anxiolytic effects are the major therapeutic benefits expected from V. officinalis herb [308,309], and thus have been a major research focus, as extensively reviewed only recently [309]. Neverthless, those responsible components and underlying mechanisms remain obscure [310].…”

Section: Valeriana Officinalismentioning

confidence: 99%

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Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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Since ancient times, plant roots have been widely used in traditional medicine for treating various ailments and diseases due to their beneficial effects. A large number of studies have demonstrated that—besides their aromatic properties—their biological activity can often be attributed to volatile constituents. This review provides a comprehensive overview of investigations into the chemical composition of essential oils and volatile components obtained from selected aromatic roots, including Angelica archangelica, Armoracia rusticana, Carlina sp., Chrysopogon zizanioides, Coleus forskohlii, Inula helenium, Sassafras albidum, Saussurea costus, and Valeriana officinalis. Additionally, their most important associated biological impacts are reported, such as anticarcinogenic, antimicrobial, antioxidant, pesticidal, and other miscellaneous properties. Various literature and electronic databases—including PubMed, ScienceDirect, Springer, Scopus, Google Scholar, and Wiley—were screened and data was obtained accordingly. The results indicate the promising properties of root-essential oils and their potential as a source for natural biologically active products for flavor, pharmaceutical, agricultural, and fragrance industries. However, more research is required to further establish the mechanism of action mediating these bioactivities as well as essential oil standardization because the chemical composition often strongly varies depending on external factors.

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Section: Valeriana Officinalismentioning

confidence: 99%

Section: Valeriana Officinalismentioning

confidence: 99%

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Lunz

Stappen

2021

Molecules

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“…One of the most commonly used herbal medicines for insomnia is Valeriana officinalis. In a recent study, Shinjyo and colleagues, in their systematic review with meta‐analysis, concluded that valerian root could be a safe and useful herb to treat sleep problems 99 . Notably, they also reported no severe adverse events associated with valerian intake.…”

Section: Non‐pharmacologic Therapiesmentioning

confidence: 99%

Non‐pharmacologic treatment of insomnia in primary care settings

Hrehová

Mezian

2021

Int J Clin Pract

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Introduction Prevalence of insomnia is higher in females and increases with higher age. Besides primary insomnia, comorbid sleep disorders are also common, accompanying different conditions. Considering the possible adverse effects of commonly used drugs to promote sleep, a non‐pharmacologic approach should be preferred in most cases. Although generally considered first‐line treatment, the non‐pharmacologic approach is often underestimated by both patients and physicians. Objective To provide primary care physicians an up‐to‐date approach to the non‐pharmacologic treatment of insomnia. Methods PubMed, Web of Science, and Scopus databases were searched for relevant articles about the non‐pharmacologic treatment of insomnia up to December 2020. We restricted our search only to articles written in English. Main message Most patients presenting with sleep disorder symptoms can be effectively managed in the primary care setting. Primary care physicians may use pharmacologic and non‐pharmacologic approaches, while the latter should be generally considered first‐line treatment. A primary care physician may opt to refer the patient to a subspecialist for refractory cases. Conclusions This paper provides an overview of current recommendations and up‐to‐date evidence for the non‐pharmacologic treatment of insomnia. This article emphasizes the importance of cognitive‐behavioral therapy for insomnia, likewise, exercise and relaxation techniques. Complementary and alternative approaches are also covered, eg, light therapy, aromatherapy, music therapy, and herbal medicine.

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“…Recently, Shinjyo et al [ 173 ], based on a systematic review of 60 studies and meta-analyses, updated and re-evaluated the most reliable literature data to assess the effectiveness of V. officinalis in ameliorating sleep and sleep-associated disorders, yet controversial and not fully conclusive. The authors reported that the inconsistent and conflicting results of the clinical trials are maybe due to the quality and to the differences in herbal preparation in addition to the aforementioned methodological limits verified.…”

Section: Preclinical and Clinical Effectiveness In Humans And Patentsmentioning

confidence: 99%

“…The therapeutic effects on sleep were found with the use of doses of 450–1410 mg of the whole root per day for up to 8 weeks. These positive biological activities could be ensured by the standardization and characterization of the phytochemical profile of the diverse active compounds present in extracts and could be improved by the combination with different sleep-promoting herbs [ 173 ]. N. grandiflora is another species tested in a preliminary clinical study; the principle compound jatamansone obtained from the rhizomes significantly reduced aggressiveness and restlessness in hyperkinetic children [ 153 ].…”

Section: Preclinical and Clinical Effectiveness In Humans And Patentsmentioning

confidence: 99%

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Das

Shin

Tundis

et al. 2021

Plants

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Valerianaceae, the sub-family of Caprifoliaceae, contains more than 300 species of annual and perennial herbs, worldwide distributed. Several species are used for their biological properties while some are used as food. Species from the genus Valeriana have been used for their antispasmodic, relaxing, and sedative properties, which have been mainly attributed to the presence of valepotriates, borneol derivatives, and isovalerenic acid. Among this genus, the most common and employed species is Valerianaofficinalis. Although valerian has been traditionally used as a mild sedative, research results are still controversial regarding the role of the different active compounds, the herbal preparations, and the dosage used. The present review is designed to summarize and critically describe the current knowledge on the different plant species belonging to Valerianaceae, their phytochemicals, their uses in the treatment of different diseases with particular emphasis on the effects on the central nervous system. The available information on this sub-family was collected from scientific databases up until year 2020. The following electronic databases were used: PubMed, Scopus, Sci Finder, Web of Science, Science Direct, NCBI, and Google Scholar. The search terms used for this review included Valerianaceae, Valeriana, Centranthus, Fedia, Patrinia, Nardostachys, Plectritis, and Valerianella, phytochemical composition, in vivo studies, Central Nervous System, neuroprotective, antidepressant, antinociceptive, anxiolytic, anxiety, preclinical and clinical studies.

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Valerian Root in Treating Sleep Problems and Associated Disorders—A Systematic Review and Meta-Analysis

Cited by 90 publications

References 154 publications

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Back to the Roots—An Overview of the Chemical Composition and Bioactivity of Selected Root-Essential Oils

Non‐pharmacologic treatment of insomnia in primary care settings

Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

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