Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Das, Gitishree; Shin, Han‐Seung; Tundis, Rosa; Gonçalves, Sandra; Tantengco, Ourlad Alzeus G.; Campos, Maria Graça; Acquaviva, Rosaria; Malfa, Giuseppe Antonio; Romano, Anabela; Robles, Joyce Ann H.; Clores, Mariel Q; Patra, Jayanta Kumar

doi:10.3390/plants10050846

Cited by 24 publications

(11 citation statements)

References 163 publications

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“…Figure 3. Chemical structures of melatonin and valerenic acid Currently, studies with valerian focused on treating anxiety and insomnia continue to advance with very positive results (Das et al, 2021;Borrás et al, 2021). Also, in trials in patients with neuropathies (Soltani et al, 2021), mental disorders such as Alzheimer's (Marde et al, 2022), and in pregnancy (Kennedy et al, 2013), the beneficial effects of valerian extracts, as well as other phytotherapeutics, have been proven with interesting results.…”

Section: Resultsmentioning

confidence: 99%

Phytomelatonin content in Valeriana officinalis L. and some related phytotherapeutic supplements

LOSADA¹,

Caño²,

Hernández‐Ruíz³

et al. 2022

International Journal of Plant Based Pharmaceuticals

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The use of medicinal plants as an alternative phytotherapeutic remedy against mild illnesses and dysfunctions is increasingly embraced by people. Among these dysfunctions, episodes of nervousness and anxiety due to lack of sleep and insomnia are becoming more and more frequent among the population. To remedy these problems, several plants with sedative activity are recommended. In particular, valerian root (Valeriana officinalis L.) is the most recommended and studied with a significant difference. This study presented a quantification of the phytomelatonin contents in valerian root and several related and recommended herb supplements against nervousness, anxiety, and insomnia. The results showed the presence of phytomelatonin in all the samples analyzed. The high phytomelatonin contents in valerian root and its supplements indicated that, in addition to the known constituents of valerian root such as valerenic acid, phytomelatonin also contributed to the phytotherapeutic activity of this plant since the relaxing and sleep-inducing activity of melatonin is well documented. The recommended daily doses of valerian are analyzed according to their phytomelatonin content, and recommendations are given on the possible synergistic action of the components of valerian as a relaxant and sleep inducer in patients with these dysfunctions. It is also recommended to document the phytomelatonin contents in phytotherapeutic preparations.

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Section: Resultsmentioning

confidence: 99%

Phytomelatonin content in Valeriana officinalis L. and some related phytotherapeutic supplements

LOSADA¹,

Caño²,

Hernández‐Ruíz³

et al. 2022

International Journal of Plant Based Pharmaceuticals

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“…The roots of the Valeriana plant have traditionally been used in European countries to treat central nervous system disorders [3]. In this study, we focused on a crude drug, the dried root of Valeriana fauriei Briq.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of capsules containing Valeriana fauriei root extract for sleep improvement: A randomized, double‐blind, placebo‐controlled, cross‐over comparative trial

Ota

Oiwa

Maki

et al. 2023

Traditional & Kampo Medicine

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AimThis clinical trial aimed to clarify the sleep‐ameliorating effects of capsules containing Valeriana fauriei root (VF) extract and their adverse effects.MethodsThe trial was a randomized, double‐blind, placebo‐controlled, cross‐over comparative clinical trial involving participants with an Athens Insomnia Scale (AIS) of 6 or higher, selected by prescreening questionnaires. After randomization, the participants took VF (2 g as VF/day) or placebo capsules for two weeks and were asked to complete the Obstructive Sleep Apnea (OSA) sleep questionnaire daily to assess their sleep status and any changes in their physical condition. On the last day of each term, the participants reported their sleep improvement experience.ResultsNo significant differences were found between the VF and placebo groups on the OSA sleep questionnaire. Significantly, more participants in the VF‐treated group experienced improvements in sleep onset and quality than those in the placebo group. The sleep onset improved particularly in those with early awakening, whereas the sleep quality particularly improved in those with midnight awakening. Although a few participants experienced physical, gastrointestinal and psychological changes when taking VF capsules, there was no significant difference from the placebo group, and no serious adverse events occurred.ConclusionWe clinically determined that VF, a folk medicine, improves sleep onset and sleep quality in people with suspected insomnia without serious adverse events at the dosage of 2 g VF/day.

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“…The roots of the Valeriana plant have traditionally been used in European countries to treat central nervous system disorders [1]. In particular, various preparations utilizing the root of V. officinalis L. (VO), registered in the 10th edition of the European Pharmacopoeia [2], are available and have sleep‐improving effects and no serious adverse events.…”

Section: Introductionmentioning

confidence: 99%

Safety evaluation of continuous administration of a high dose of Valeriana fauriei root extract in mice and in humans through an open‐label study

Ota,

Oiwa,

Maki

et al. 2023

Traditional & Kampo Medicine

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AimThis study aimed to clarify the safety of Valeriana fauriei root (VF) ethanol extract through in vivo and clinical trials.MethodsMice were divided into VF and control groups. They were given VF (4 g VF/kg/day) or the vehicle mixed in the powdered food for four weeks. Food consumption and body weight changes were evaluated, and blood biochemistry and organ weights were assessed on the last day. In addition, an open‐label study was conducted on healthy subjects who took VF capsules (10 g VF/body/day) for four weeks and were asked to report any changes in their physical condition. Physical, hematologic, blood biochemical examination and urinalysis were performed before, two weeks, and four weeks into the study.ResultsFood consumption and weight gain in mice did not differ between the VF and control groups, except for experimental error, and there were no particular differences in the weights of the brain, lung, heart, liver, spleen, and kidney. In mice, VF administration resulted in small but significant decreases in albumin in males and females, and total cholesterol and high‐density lipoprotein cholesterol in females only. These levels were unchanged, but daytime sleepiness was observed in humans.ConclusionSince there was little change in the experimental values at continuous high doses of VF at 10 g/day, it can be concluded that approximately one‐fifth of this dose (2 g VF/day) is less harmful. However, daytime sleepiness should be considered.

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Plant Species of Sub-Family Valerianaceae—A Review on Its Effect on the Central Nervous System

Cited by 24 publications

References 163 publications

Phytomelatonin content in Valeriana officinalis L. and some related phytotherapeutic supplements

Phytomelatonin content in Valeriana officinalis L. and some related phytotherapeutic supplements

Evaluation of capsules containing Valeriana fauriei root extract for sleep improvement: A randomized, double‐blind, placebo‐controlled, cross‐over comparative trial

Safety evaluation of continuous administration of a high dose of Valeriana fauriei root extract in mice and in humans through an open‐label study

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