Val66Met polymorphism is associated with decreased likelihood for pediatric headache and migraine

Koute, Vasiliki; Michalopoulou, Amalia; Siokas, Vasileios; Aloizou, Athina‐Maria; Rikos, Dimitrios; Bogdanos, Dimitrios P.; Kontopoulos, E.; Grivea, Ioanna N.; Syrogiannopoulos, George A.; Papadimitriou, Alexandros; Hadjigeorgiou, Georgios M.; Dardiotis, Efthimios

doi:10.1080/01616412.2021.1922181

Cited by 5 publications

(4 citation statements)

References 65 publications

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“…The comparison and validation of the results in an independent population are needed. Besides, we tried to replicate previously reported variants contributing to migraine in our cohort [10,[12][13][14]47]. However, all these variants were not included in the TWB array, because it was designed based on genotyping data of Taiwanese Han Chinese participants [19].…”

Section: Discussionmentioning

confidence: 99%

“…Chang et al reported that common variants at 5q33.1 correlate with migraine in African-American children [13]. Koute et al reported that the existence of BDNF rs6265 correlates with a lower risk of pediatric headache and migraine in Greece [14]. However, limited studies have examined the correlation of genetic susceptibility markers and age-at-onset of migraine in an Asian population.…”

Section: Introductionmentioning

confidence: 99%

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Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

et al. 2021

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Background Considering the involvement of genetics in migraine pathogenesis in diverse ethnic populations, genome-wide association studies (GWAS) are being conducted to identify migraine-susceptibility genes. However, limited surveys have focused on the onset age of migraine (AoM) in Asians. Therefore, in this study, we aimed to identify the susceptibility loci of migraine considering the AoM in an Asian population. Methods We conducted a GWAS in 715 patients with migraine of Han Chinese ethnicity, residing in Taiwan, to identify the susceptibility genes associated with AoM. Based on our standard demographic questionnaire, the population was grouped into different subsets. Single-nucleotide polymorphism (SNP) associations were examined using PLINK in different AoM onset groups. Results We discovered eight novel susceptibility loci correlated with AoM that reached the GWAS significance level in the Han Chinese population. First, rs146094041 in ESRRG was associated with AoM $$\le$$ ≤ 12 years. The other SNPs including rs77630941 in CUX1, rs146778855 in CDH18, rs117608715 in NOL3, rs150592309 in PRAP1, and rs181024055 in NRAP were associated with the later AoM. Conclusions To our knowledge, this is the first GWAS to investigate the AoM in an Asian Han Chinese population. Our newly discovered susceptibility genes may have prospective associations with migraine pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

et al. 2021

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“…In a recent case control study conducted in Greece on a pediatric population [111], a possible protective role of the Val66Met polymorphism in the pathogenesis of migraine was investigated. It would act by reducing the release of BDNF (brain-derived neurotrophic factor) [105] and participating in the regulation of pain signalling and central sensitization [112,113].…”

Section: Future Perspectivesmentioning

confidence: 99%

Migraine and Its Equivalents: What Do They Share? A Narrative Review on Common Pathophysiological Patterns

Frattale

Ruscitto

Papetti

et al. 2021

Life

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Migraine is the first in order of frequency of the neurological disorders, affecting both adult and paediatric populations. It is also the first cause of primary headaches in children. Migraine equivalents are periodic disorders that can be associated with migraine or considered as prognostic features of a future migraine manifestation. Despite the mechanisms underlying migraine and its equivalents are not entirely clear, several elements support the hypothesis of common pathophysiological patterns shared by these conditions. The aim of this review is thus to analyze the literature in order to highlight which currently known mechanisms may be common between migraine and its equivalents.

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“… 11 Furthermore, several genetic studies on pediatric migraine have reported polymorphisms associated with migraine. 12 , 13 Similarly, numerous studies have shown novel susceptibility genes associated with insomnia. Hammerschlag et al identified three loci and seven genes associated with insomnia.…”

Section: Introductionmentioning

confidence: 99%

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

An¹,

Tsai²,

Liang³

et al. 2022

NSS

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Purpose Although insomnia and migraine are often comorbid, the genetic association between insomnia and migraine remains unclear. This study aimed to identify susceptibility loci associated with insomnia and migraine comorbidity. Patients and Methods We performed a genome-wide association study (GWAS) involving 1063 clinical outpatients at a tertiary hospital in Taiwan. Migraineurs with and without insomnia were genotyped using the Affymetrix Axiom Genome-Wide TWB 2.0. We performed association analyses for the entire cohort and stratified patients into the following subgroups: episodic migraine (EM), chronic migraine (CM), migraine with aura (MA), and migraine without aura (MoA). Potential correlations between SNPs and clinical indices in migraine patients with insomnia were examined using multivariate regression analysis. Results The SNP rs1178326 in the gene HDAC9 was significantly associated with insomnia. In the EM, CM, MA, and MoA subgroups, we identified 30 additional susceptibility loci. Multivariate regression analysis showed that SNP rs1178326 also correlated with higher migraine frequency and the Migraine Disability Assessment (MIDAS) questionnaire score. Finally, two SNPs that had been previously reported in a major insomnia GWAS were also significant in our migraineurs, showing a concordant effect. Conclusion In this GWAS, we identified several novel loci associated with insomnia in migraineurs in a Han Chinese population in Taiwan. These results provide insights into the possible genetic basis of insomnia and migraine comorbidity.

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Val66Met polymorphism is associated with decreased likelihood for pediatric headache and migraine

Cited by 5 publications

References 65 publications

Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Migraine and Its Equivalents: What Do They Share? A Narrative Review on Common Pathophysiological Patterns

Identification of Novel Genetic Variants Associated with Insomnia and Migraine Comorbidity

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