Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Tsai, Chia‐Kuang; Liang, Chih‐Sung; Lin, Guan‐Yu; Tsai, Chia‐Lin; Lee, Jiunn‐Tay; Sung, Yueh‐Feng; Lin, Yu‐Kai; Hung, Kuo‐Sheng; Chen, Wei‐Liang; Yang, Fu‐Chi

doi:10.1186/s10194-021-01301-y

Cited by 17 publications

(13 citation statements)

References 49 publications

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“…Studies have suggested that the link between migraine and diabetes may be caused by insulin resistance, which plays a vital role in developing metabolic syndrome and is also a risk factor for migraine [26,107]. A GWAS study conducted in 715 patients with Han Chinese ethnicity in Taiwan discovered that one SNP (rs146094041) in the Oestrogen related receptor gamma gene (ESRRG) was genome-wide significantly associated (p = 3.40 × 10 −9 ) with migraine onset before the age of 12 years (www.ebi.ac.uk/gwas/, accessed on 13 March 2022) [242]. Given the involvement of sex hormones, especially oestrogen, in migraine pathophysiology [107,243], the link between migraine and diabetes may be partially explained by sex hormones.…”

Section: Discussionmentioning

confidence: 99%

Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration

Islam

Nyholt

2022

Genes

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Migraine and glucose-related (glycaemic) traits (fasting glucose, fasting insulin, and type 2 diabetes) are common and complex comorbid disorders that cause major economic and social burdens on patients and their families. Studies on the relationship between migraine and glucose-related traits have yielded inconsistent results. The purpose of this review is to synthesise and discuss the information from the available literature on the relationship between fasting glucose, fasting insulin, and type 2 diabetes (T2D) with migraine. Publications on migraine and fasting glucose, migraine and fasting insulin, and migraine and T2D were identified from a PubMed and Google Scholar database search and reviewed for this article. Multiple publications have suggested that the comorbidity of migraine and glucose-related traits may have a similar complex pathogenic mechanism, including impaired glucose homeostasis, insulin resistance, reduced cerebrovascular reactivity, abnormal brain metabolism, shared genetic factors, neurotransmitters, and sex hormones. Furthermore, several studies have found a bi-directional link between migraine with insulin resistance and T2D. There is strong evidence for a biological association between migraine headache and glucose-related traits, and burgeoning evidence for shared genetic influences. Therefore, genetic research into these comorbid traits has the potential to identify new biomarkers and therapeutic targets and provide biological insight into their relationships. We encourage healthcare professionals to consider the co-occurrence of migraine with glucose-related traits in the evaluation and treatment of their patients.

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Section: Discussionmentioning

confidence: 99%

Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration

Islam

Nyholt

2022

Genes

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“…Stritt reported that exercise increased serotonin (5-HT) levels, even with low intensity exercise [ 39 ], and 5-HT played an important role in many cognitive processes. Tsai reported that acute exercise-induced neurocognitive changes were associated with real-time changes in circulating levels of neuroprotective growth factors, and acute exercise increased the amplitude of the event-related potential, P3 [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Normal pace walking is beneficial to young participants’ executive abilities

Zhang

Xiang

Shi

et al. 2022

BMC Sports Sci Med Rehabil

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Background Exercise can improve cognitive function. The impact of acute exercise on cognition is related to exercise intensity. This study aimed to explore whether normal walking had a beneficial effect on cognition. Methods Compared with standing still, thirty healthy young men walked on a treadmill at a normal pace, and completed the Stroop test. Near-infrared spectroscopy was used to monitor the hemodynamic changes of the prefrontal cortex during the entire experiment. Results Studies showed that normal walking did not stimulate higher average cerebral oxygen in the PFC, but the peak cerebral oxygen in cognitive tests during walking was higher (Stroop Word: 2.56 ± 0.43 and 3.80 ± 0.50, P < 0.01, Stroop Color: 2.50 ± 0.37 and 3.66 ± 0.59, P < 0.05, Stroop Color-Word: 4.13 ± 0.55 and 5.25 ± 0.66, P < 0.01, respectively), and better results were achieved in the Stroop Color-Word test, which was reflected in faster reaction times (49.18 ± 1.68 s, 56.92 ± 2.29 s, respectively, P < 0.001) and higher accuracies (46.19 ± 0.69, 44.15 ± 0.91, respectively, P = 0.018). Conclusion For healthy young people, even a normal walk is therefore good for cognition.

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“…It was also found that first-degree relatives had an increased risk of migraines with and without aura [37]. In the GWAS study, which included the determination of genes involved in the age of onset and pathology of migraines in Asians, one SNP was associated with 12 years of age and five SNPs were associated with migraines [38]. However, an important limitation of these studies is the patient grouping method, with grouping based on aura and family history.…”

Section: Discussionmentioning

confidence: 99%

Screening for Copy Number Variations of the 15q13.3 Hotspot in CHRNA7 Gene and Expression in Patients with Migraines

Özaltun

Geyik

Yılmaz

2021

CIMB

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Background: a migraine is a neurological disease. Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated. We investigated the effects of the CNV and gene expression at the location 15q13.3 in the Cholinergic Receptor Nicotinic Alpha 7 Subunit (CHRNA7) gene, which we believe to be effective in the migraine clinic. Methods: we evaluated changes in CHRNA7 gene expression levels and CNV of 15q13.3 in patients with migraine (n = 102, with aura, n = 43; without aura, n = 59) according to healthy controls (n = 120) by q-PCR. The data obtained were analyzed against the reference telomerase reverse transcriptase (TERT) gene with the double copy number by standard curve analysis. Copy numbers were graded as a normal copy (2), gain (2>), and loss (<2). Results: we analyzed using the 2−ΔΔCT calculation method. The CHRNA7 gene was significantly downregulated in patients (p < 0.05). The analysis of CNV in the CHRNA7 gene was statistically significant in the patient group, according to healthy controls (p < 0.05). A decreased copy number indicates a dosage loss. However, no significant difference was observed among gain, normal, and loss copy numbers and expression values in patients (p > 0.05). The change in CNV was not associated with the downregulation of the CHRNA7 gene. Conclusion: Downregulation of the CHRNA7 gene may contribute to the formation of migraine by inactivation of the alpha-7 nicotinic receptor (α7nAChR). The association of CNV gains and losses with migraines will lead to better understanding of the molecular mechanisms and pathogenesis, to better define the disease, to be used as a treatment target.

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Identifying genetic variants for age of migraine onset in a Han Chinese population in Taiwan

Cited by 17 publications

References 49 publications

Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration

Glucose-Related Traits and Risk of Migraine—A Potential Mechanism and Treatment Consideration

Normal pace walking is beneficial to young participants’ executive abilities

Screening for Copy Number Variations of the 15q13.3 Hotspot in CHRNA7 Gene and Expression in Patients with Migraines

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