Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study∗∗See accompanying Editorial, in this issue.

Rush, A. John; George, Mark S.; Sackeïm, Harold A.; Marangell, Lauren B.; Husain, Mustafa M.; Giller, Cole A.; Nahas, Ziad; Haines, Stephen J.; Simpson, Richard K.; Goodman, Robert

doi:10.1016/s0006-3223(99)00304-2

Cited by 572 publications

(227 citation statements)

References 34 publications

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“…The efficacy of VNS for treatment-resistant depression was evaluated in a randomized, controlled acute-phase trial with a one-year continuation. 80 Of 266 participants enrolled in the acute-phase trial, 235 received the implanted VNS device; subsequently, 112 received active treatment and 110 received sham treatment (i.e., the implanted device was not activated). After 10 weeks, there were statistically significant improvements on the Inventory of Depressive Symptomatology (IDS)-Self Report (IDS-SR; a secondary measure for depression) and a trend for the primary measure (HAM-D) for VNS versus sham treatment.…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

2007

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Summary: Antiepileptic drugs (AEDs) are commonly utilized for nonepileptic conditions, including various psychiatric disorders and pain syndromes. Evidence for their benefit in these nonepileptic conditions varies widely among different drugs, but there is, in general, a paucity of published multicenter randomized double-blind trials. Variable levels of evidence suggest that lamotrigine and the vagal nerve stimulator have antidepressant properties. Carbamazepine, valproate, lamotrigine, and oxcarbazepine appear to have mood stabilizing properties while gabapentin, pregabalin, and tiagabine have anxiolytic benefits. Barbiturates, topiramate, and possibly phenytoin may precipitate or exacerbate depression. Underlying depression and anxiety symptoms may be exacerbated by levetiracetam, while psychotic symptoms have rarely been reported with topiramate, levetiracetam, and zonisamide. Pregabalin, gabapentin, carbamazepine, and oxcarbazepine have been used to treat neuropathic pain such as postherpetic neuralgia, and diabetic polyneuropathy. Topiramate and divalproex sodium have utility in the prophylaxis or acute treatment of migraine. Further rigorous studies are needed to clarify the utility of AEDs in nonepileptic conditions.

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Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

2007

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“…In adults without epilepsy, VNS has caused a significant reduction in depressive symptoms. 7 Armitage et al 8 presented an improvement in both depression and sleep architecture. Galli et al 9 recently confirmed the positive effect of VNS on QOL in adults with epilepsy and learning disability and presented improvement in daytime vigilance.…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Hallböök

Lundgren

Köhler

et al. 2005

European Journal of Paediatric Neurology

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“…Rush et al conducted the first study to evaluate VNS efficacy in treatment-resistant depression. 45 In this multicenter, open-label study, 30 patients had a VNS device implanted. It was turned on after completion of a 2-week, post implantation, single-blind "recovery period".…”

Section: Rtms For Other Psychiatric Disordersmentioning

confidence: 99%

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

Braga

Petrides²

2007

Rev. Bras. Psiquiatr.

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A b s t r a c t Objective: This paper reviews the current knowledge of somatic treatment in psychiatry, with a focus on treatment-resistant psychiatric disorders. Method: A computerized search of the literature was conducted on Medline using the words "electroconvulsive therapy", "transcranial magnetic stimulation", "vagus nerve stimulation", "deep brain stimulation", and "magnetic seizure therapy". References from each paper were also screened. Results: The development of new non-pharmacological psychiatric interventions in the past decades has renewed the clinical and research interest in somatic therapies. Although electroconvulsive therapy remains the only somatic treatment with undisputed efficacy; transcranial magnetic stimulation, vagus nerve stimulation and deep brain stimulation all offer potential as novel means of psychiatric treatment. Conclusions: New treatment modalities still have an insufficient body of data. Notwithstanding, biological strategies continue to hold promise as a safer and more effective approach to psychiatric treatment. Descriptors: Brain diseases; Electroconvulsive therapy; Transcranial magnetic stimulation; Vagus nerve; Deep brain stimulationResumo Objetivo: O presente artigo é uma revisão do conhecimento atual relativo às terapias somáticas em psiquiatria, com foco em transtornos psiquiátricos resistentes ao tratamento usual. Método: Foi realizada uma pesquisa computadorizada da literatura no Medline utilizando as palavras "eletroconvulsoterapia", "estimulação magnética transcraniana ", "terapia magnética convulsiva", "estimulação do nervo vago" e "estimulação cerebral profunda", com todos os termos traduzidos para o idioma inglês. Referên-cias listadas em cada artigo foram também analisadas. Resultados: O desenvolvimento de novos tratamentos psiquiátricos não farmacológicos nas últimas décadas renovou o interesse em terapias somáticas. A despeito de a eletroconvulsoterapia continuar a ser o único tratamento somático com eficácia estabelecida, a estimulação magnética transcraniana, a terapia magnética convulsiva, a estimulação do nervo vago e a estimulação cerebral profunda são potencialmente novas modalidades de tratamento psiquiátrico. Conclusões: Novas modalidades de tratamento ainda padecem de falta de conhecimento cientifico adequado. Entretanto, estratégias somáticas ainda representam uma promessa como formas mais eficazes e seguras de tratamento psiquiátrico.

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Vagus nerve stimulation (VNS) for treatment-resistant depressions: a multicenter study∗∗See accompanying Editorial, in this issue.

Cited by 572 publications

References 34 publications

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

Use of Antiepileptic Drugs for Nonepileptic Conditions: Psychiatric Disorders and Chronic Pain

Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Terapias somáticas para transtornos psiquiátricos resistentes ao tratamento

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