Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Hallböök, Tove; Lundgren, Johan; Köhler, Sven; Blennow, Gösta; Strömblad, Lars-Göran; Rosén, Ingmar

doi:10.1016/j.ejpn.2005.08.004

Cited by 62 publications

(39 citation statements)

References 37 publications

(34 reference statements)

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“…Quality of life was improved in 13/15, of whom 11 also had improved seizure severity and mood; five, in addition, had an improvement in depressive parameters. The same group (Hallböök et al ., ) examined the sleep structure in these 15 children. 10 children had increased slow‐wave sleep and, of these, eight had improved quality of life.…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Psychiatric and Behavioural Disorders in Children with Epilepsy: an ILAE Task Force Report

Besag¹,

Aldenkamp²,

Caplan³

et al. 2016

Epileptic Disorders

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A subtle behavioural or cognitive manifestation of epilepsy can be defined in two ways. First, epileptiform discharges not presenting as obvious seizures may nevertheless affect cognition and/or behaviour. Second, the actual seizures may be obvious but the way they affect cognition or behaviour may not be. There is a growing body of evidence indicating that the epileptiform discharges in benign epilepsy with centrotemporal spikes can affect behaviour and cognition. The focal discharges in other forms of epilepsy can also be associated with behavioural change. The Landau‐Kleffner syndrome, the CSWS syndrome, transitory cognitive impairment and transient epileptic amnesia provide further examples of cognitive and behavioural manifestations resulting from subtle manifestations of the epilepsy. Prompt, effective antiepileptic treatment with medication or surgery can improve behaviour and cognition in at least some cases.

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Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Psychiatric and Behavioural Disorders in Children with Epilepsy: an ILAE Task Force Report

Besag¹,

Aldenkamp²,

Caplan³

et al. 2016

Epileptic Disorders

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“…VNS seizure patients report enhanced mood, 70,71 reduced daytime sleepiness and increase alertness 72 independent of seizure control, increased slow wave sleep, 73 improved cognition, 74 memory, 75 and quality of life. 71,76 Children with VNS are noted to have enhanced verbal communication, school performance, 77 quality of life, and cost savings.…”

Section: Vns For Epilepsymentioning

confidence: 99%

Vagus nerve stimulation to augment recovery from severe traumatic brain injury impeding consciousness: a prospective pilot clinical trial

Chen

Flanagan

Samadani

2013

Neurological Research

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Objectives-Traumatic brain injury has a high morbidity and mortality in both civilian and military populations. Blast and other mechanisms of traumatic brain injury damage the brain by causing neurons to disconnect and atrophy. Such traumatic axonal injury can lead to persistently vegetative and minimally conscious states, for which limited treatment options exist, including physical, occupational, speech and cognitive therapies.More than 60,000 patients have received vagus nerve stimulation for epilepsy and depression. In addition to decreased seizure frequency and severity, patients report enhanced mood, reduced daytime sleepiness independent of seizure control, increased slow wave sleep, and improved cognition, memory, and quality of life.Early stimulation of the vagus nerve accelerates the rate and extent of behavioral and cognitive recovery after fluid percussion brain injury in rats.Methods-We recently obtained FDA approval for a pilot prospective randomized crossover trial to demonstrate objective improvement in clinical outcome by placement of a vagus nerve stimulator in patients who are recovering from severe traumatic brain injury. Our hypothesis is that stimulation of the vagus nerve results in increased cerebral blood flow and metabolism in the forebrain, thalamus and reticular formation, which promotes arousal and improved consciousness, thereby improving outcome after traumatic brain injury resulting in minimally conscious or persistent vegetative states.Discussion-If this study demonstrates that vagus nerve stimulation can safely and positively impact outcome, then a larger randomized prospective crossover trial will be proposed.

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“…Quality of life was improved in 13/15, of whom 11 also had improved seizure severity and mood; five, in addition, had an improvement in depressive parameters. The same group (Hallböök et al, 2005a) examined the sleep structure in these 15 children. 10 children had increased slow-wave sleep and, of these, eight had improved quality of life.…”

Section: Vagus Nerve Stimulationmentioning

confidence: 99%

Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Behavioural effects of epilepsy surgery

Besag

Caplan

Aldenkamp

et al. 2016

Epileptic Disorders

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There are relatively few studies of the behavioural outcome of epilepsy surgery in children that have used standardised behavioural measures before and after the procedure. Those investigations that have used such measures are often on mixed groups with mixed pathology, implying that the numbers, when stratified, are very small. They are also often retrospective. Furthermore, because placebo surgery is generally not an option, the studies have been open and they are usually uncontrolled. The few available data suggest that, although individual children may benefit or deteriorate, there is little overall group effect of temporal or extratemporal surgery on behavioural/psychiatric outcome. Hemispherectomy has traditionally been associated with the expectation of marked behavioural improvement but firm data are lacking. Multiple subpial transection performed for electrical status epilepticus of slow‐wave sleep in the Landau‐Kleffner syndrome can result in marked improvements in cognition and behaviour. Vagus nerve stimulation appears to improve quality of life and mood/behaviour but again the quality of the data has been questioned. There is a need for large, prospective, multicentre, collaborative studies using standardised cognitive and behavioural measures before and after surgery to provide an adequate database on the outcome of various categories of procedures, pathologies and patients.

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Beneficial effects on sleep of vagus nerve stimulation in children with therapy resistant epilepsy

Cited by 62 publications

References 37 publications

Psychiatric and Behavioural Disorders in Children with Epilepsy: an ILAE Task Force Report

Psychiatric and Behavioural Disorders in Children with Epilepsy: an ILAE Task Force Report

Vagus nerve stimulation to augment recovery from severe traumatic brain injury impeding consciousness: a prospective pilot clinical trial

Psychiatric and Behavioural Disorders in Children with Epilepsy (ILAE Task Force Report): Behavioural effects of epilepsy surgery

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