VagiSite Bioadhesive Technology

Levinson, R. Saul; Thompson, Daniel

doi:10.1201/9780203910337.ch66

Cited by 3 publications

(2 citation statements)

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“…Xanthan gum and HPMC-K4M were used to provide smoothness and better spreadability along with improved release properties. All of these bioadhesive polymers are stable over a wide range of pH (3)(4)(5)(6)(7)(8)(9)(10). In the ex vivo experiment, the ABBV gel retention time was up to 12-13 h. The developed ABBV gel showed more resistance to viscosity changes due to SVF absorption and thus showed better retention than the commercial vaginal gel/cream which started to leak within 5-6 h. Besides, creams do not have the capacity to absorb and hold fluid since bioadhesive gels do and leak out when the surface of the vaginal wall gets lubricated by simulated vaginal fluid.…”

Section: Acid Buffering Bioadhesive Vaginal Gelmentioning

confidence: 99%

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Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Ahmad¹,

Alam²,

Khan³

et al. 2008

Acta Pharmaceutica

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Development andin vitroevaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infectionsAn acid buffering bioadhesive vaginal (ABBV) gel was developed for the treatment of mixed vaginal infections. Different bioadhesive polymers were evaluated on the basis of their bioadhesive strength, stability and drug release properties. Bioadhesion and release studies showed that guar gum, xanthan gum and hydroxypropyl methylcelullose K4M formed a good combination of bioadhesive polymers to develop the ABBV gel. Monosodium citrate was used as an acid buffering agent to provide acidic pH (4.4). The drugs clotrimazole (antifungal) and metronidazole (antiprotozoal as well as antibacterial) were used in the formulation along withLactobacillusspores to treat mixed vaginal infections. Theex vivoretention study showed that the bioadhesive polymers hold the gel for 12-13 hours inside the vaginal tube. Results of thein vitroantimicrobial study indicated that the ABBV gel had better antimicrobial action than the commercial intravaginal drug delivery systems and retention was prolonged in anex vivoretention experiment.

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Section: Acid Buffering Bioadhesive Vaginal Gelmentioning

confidence: 99%

“…To overcome this problem, bioadhesive polymers are added to VDDS. Bioadhesive polymers can hold the drug delivery systems in the vaginal tube by interacting with vaginal mucosa and thereby increase patient compliance as well of delivery system efficiency (8,9).…”

mentioning

confidence: 99%

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Ahmad¹,

Alam²,

Khan³

et al. 2008

Acta Pharmaceutica

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Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems

et al. 2009

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The vagina has been studied as a suitable site for local and systemic delivery of drugs. There are a large number of vaginal medications on the market. Most of them, however, require frequent applications due to their short vaginal residence time. A prolonged vaginal residence time of formulations is therefore a key parameter for improved therapeutic efficacy. Promising approaches for prolonging the residence time base on mucoadhesion, were in-situ sol-to-gel transition and mechanical fixation. Mucoadhesive drug delivery systems can be tailored to adhere to the vaginal tissue. In-situ gelling systems offer the advantage of increased viscosity in vaginal cavity and consequently reduce outflow from the vagina. Mechanical fixation needs specially shaped drug delivery systems and reduce the frequency of administration significantly. In this review, an overview on these different strategies and systems is provided. Furthermore, the techniques to evaluate the potential of these systems for prolonged vaginal residence time are described. _______________________________________________________________________________________

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Formulation and Evaluation of In Situ forming Polymeric Drug Delivery Systems for Mixed Vaginal Infection

Abass

Kamel

2014

BJPR

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VagiSite Bioadhesive Technology

Cited by 3 publications

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Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Strategies to Prolong the Intravaginal Residence Time of Drug Delivery Systems

Formulation and Evaluation of In Situ forming Polymeric Drug Delivery Systems for Mixed Vaginal Infection

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