Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Ahmad, Feroz; Alam, Mohammad Mumtaz; Khan, Zeenat; Khar, Roop K.; Ali, Mushir

doi:10.2478/v10007-008-0023-2

Cited by 40 publications

(20 citation statements)

References 17 publications

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“…Also chlorhexidine carried by carboxymethylcellulose or by chitosan/carboxymethylcellulose have been investigated [138]. These dosage forms were prepared, polycarbophil and sodium carboxymethylcellulose, both formulations being buffered with monosodium citrate [139,140]. Tablet and gel formulations exhibited enhanced mucoadhesion when compared with commercial products and were able to completely release clotrimazole and metronidazole.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

New strategies for local treatment of vaginal infections

Palmeira‐de‐Oliveira

Martinez-de-Oliveira

2015

Advanced Drug Delivery Reviews

148

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Section: Accepted Manuscriptmentioning

confidence: 99%

New strategies for local treatment of vaginal infections

Palmeira‐de‐Oliveira

Martinez-de-Oliveira

2015

Advanced Drug Delivery Reviews

148

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“…Sustained release for 6 h. Excellent in-vitro anti-fungal activity (Ahmad et al, 2008) Nonoxynol-9 Bio-adhesive gel Carbopol934P Initial high burst for 2min followed by sustained release for 7 h (Lee et al, 1996) Clotrimazole Bio-adhesive gel Combination of Xanthan gum and HPMC-K4M Sustained release for 6 h. …”

Section: Cyclodextrin In Vaginal Therapymentioning

confidence: 99%

Advanced topical drug delivery system for the management of vaginal candidiasis

et al. 2014

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Vaginal candidiasis or vulvovaginal candidiasis (VC) is a common mucosal infection of vagina, mainly caused by Candida species. The major symptoms of VC are dyspareunia, pruritis, itching, soreness, vagina as well as vulvar erythema and edema. Most common risk factors that lead to the imbalance in the vaginal micro biota are the use of antibiotics, pregnancy, diabetes mellitus, immuno suppression as in AIDS or HIV patients, frequent sexual intercourse, spermicide and intra-uterine devices and vaginal douching. Various anti-fungal drugs are available for effective treatment of VC. Different conventional vaginal formulations (creams, gels, suppositories, powder, ointment, etc.) for VC are available today but have limited efficacy because of lesser residence time on vaginal epithelium due to self-cleansing action of vagina. So to overcome this problem, an extended and intimate contact with vaginal mucosa is desired; which can be accomplished by utilizing mucoadhesive polymers. Mucoadhesive polymers have an excellent binding capacity to mucosal tissues for considerable period of time. This unique property of these polymers significantly enhances retention time of different formulations on mucosal tissues. Currently, various novel formulations such as liposomes, nano-and microparticles, micro-emulsions, bio-adhesive gel and tablets are used to control and treat VC. In this review, we focused on current status of vaginal candidiasis, conventional and nanotechnology inspired formulation approaches.

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“…An applied force 150 g was given to allow the wafers to adhere to the bovine buccal mucosa membrane with return distance 10 mm. The experiment was carried out at room temperature (Ahmad et al, 2008).…”

Section: In Vitro Analysis Of Buccoadhesionmentioning

confidence: 99%

“…Radial swelling was calculated by diameter method from the following equation (Ahmad et al, 2008). Â 100…”

Section: Estimation Of Radial Swelling Index Of the Wafersmentioning

confidence: 99%

Comparative study on the predictability of statistical models (RSM and ANN) on the behavior of optimized buccoadhesive wafers containing Loratadine and their in vivo assessment

Chakraborty

Parcha²,

Chakraborty

et al. 2014

Drug Delivery

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Objective: Buccoadhesive wafer dosage form containing Loratadine is formulated utilizing Formulation by Design (FbD) approach incorporating sodium alginate and lactose monohydrate as independent variable employing solvent casting method. Methods: The wafers were statistically optimized using Response Surface Methodology (RSM) and Artificial Neural Network algorithm (ANN) for predicting physicochemical and physico-mechanical properties of the wafers as responses. Morphologically wafers were tested using SEM. Quick disintegration of the samples was examined employing Optical Contact Angle (OCA). Results: The comparison of the predictability of RSM and ANN showed a high prognostic capacity of RSM model over ANN model in forecasting mechanical and physicochemical properties of the wafers. The in vivo assessment of the optimized buccoadhesive wafer exhibits marked increase in bioavailability justifying the administration of Loratadine through buccal route, bypassing hepatic first pass metabolism.

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Development and in vitro evaluation of an acid buffering bioadhesive vaginal gel for mixed vaginal infections

Cited by 40 publications

References 17 publications

New strategies for local treatment of vaginal infections

New strategies for local treatment of vaginal infections

Advanced topical drug delivery system for the management of vaginal candidiasis

Comparative study on the predictability of statistical models (RSM and ANN) on the behavior of optimized buccoadhesive wafers containing Loratadine and their in vivo assessment

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