Vaginal vs. oral misoprostol for mid‐trimester abortion

Nigam, Aruna; Singh, Virender; Prakash, Anjali

doi:10.1016/j.ijgo.2005.11.010

Cited by 22 publications

(10 citation statements)

References 4 publications

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“…Out of these, 32 (32.3%) patients had anhydramnios (study group) and 67 (67.7%) had some anomalies with normal amniotic fluid (control group). Mean patient age was 28.10 ± 5.72 (15-41) and mean gestational age was 17.94 ± 3.40 (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27) weeks. Sixty-one (61.6%) patients had previous vaginal delivery, 28 (28.3%) had previous cesarean section, and 10 (10.1%) patients were nulliparous.…”

Section: Resultsmentioning

confidence: 99%

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Does the presence of anhydramnios affect the duration of medical abortion?

Karapınar

Güngören²,

Dolapçıoğlu³

et al. 2016

Ginekol Pol

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Objectives: The aim of the study was to determine whether anhydramnios affected the duration of medical abortion in cases with various indications as compared to cases with normal amniotic fluid volume. Material and methods:Patients who were admitted to our clinic because of medical abortion between January 2010-December 2013 were included in this retrospective study. A total of 32 pregnant women with anhydramnios (study group) and 67 pregnant women with normal amniotic fluid volume but with fetal abnormality (control group) were included in the study. Patient age, gravidity, parity, gestational age, previous delivery route, and duration of the abortion were recorded.Results: Mean duration of the abortion in the study group was 71.93 ± 47.51 h as compared to 79.08 ± 52.62 h in the control group. There were no statistically significant differences between the two groups in terms of duration of the abortion (p = 0.516). Also, we found no statistically significant differences in duration of the abortion with regard to previous delivery route (p = 0.220).Conclusions: There were no statistically significant differences between the study group and controls in terms of duration of the abortion. In addition, neither parity nor previous delivery route affected the duration of the abortion.

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Section: Resultsmentioning

confidence: 99%

“…Doses of 600 and 800 μg had comparable effects on the abortion rates, but are associated with higher incidence of fever, diarrhea, nausea, and vomiting [16]. Vaginal administration of misoprostol is more effective than other routes of administration and the incidence of side effects is lower [17][18].…”

Section: Discussionmentioning

confidence: 97%

Does the presence of anhydramnios affect the duration of medical abortion?

Karapınar

Güngören²,

Dolapçıoğlu³

et al. 2016

Ginekol Pol

View full text Add to dashboard Cite

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“…5,6 Although vaginal misoprostol is more effective in the first trimester many studies have reported no difference in efficacy for second trimester abortion. 7,8 Also it has often been found that absorption through the vaginal route is inconsistent and that the patients find vaginal administration uncomfortable. Oral misoprostol reaches a high peak concentration in blood very quickly followed by a rapid fall in plasma level.…”

Section: Discussionmentioning

confidence: 99%

Randomised comparison of oral and vaginal misoprostol when combined with mifepristone for termination of second trimester pregnancy

Madhuri

Veena

Manjunath

2016

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONAdvances in fetal diagnosis have resulted in increased number of second trimester pregnancy terminations. Invasive means of second trimester medical abortion have long been available. In the past few years, however, the ability to safely and effectively accomplish non invasive second trimester abortions has evolved considerably.A combination of mifepristone, a progesterone antagonist, and misoprostol, a synthetic prostaglandin E1 analogue, is effective for medical abortion in second trimester. The latter has the advantages of being cost effective, stable at room temperature and is a strong uterotonic. Mifepristone, (RU 486, a substitute 19-norethisterone derivative) is a progesterone receptor blocker, causes intrauterine fetal demise and sensitises the uterus to the activity of prostaglandins.1 The two drugs together have proven efficacy in first trimester abortion. 2The optimal regimen for second trimester is still under investigation, but is required to have a high complete abortion rate, short induction-abortion interval, low Methods: 60 women who were pregnant between 13 and 20 weeks were included in the study. They were divided into two groups by random sampling method and they all received 200 mg of mifepristone orally on day 1. 36 hours later they received 200 µg of misoprostol vaginally or 400 µg of misoprostol orally every 3 hours as determined by the random sampling method. Main outcome measures were induction abortion interval, complete abortion rate and side effects. Results: There was a statistical difference in the amount of misoprostol required in the oral and the vaginal group, the total dose being higher in the oral group. The mean induction-abortion interval in the vaginal group was 6.2 hrs and oral group was 11.6 hrs and this difference was statistically significant. There was no statistical difference in the complete abortion rate of the two groups. There was no difference in the side effects caused by both routes of misoprostol administration. Conclusion: 200 µg misoprostol inserted vaginally is better than 400 µg of oral misoprostol, 36 hours after administration of tab. Mifepristone 200 mg for termination of second trimester pregnancy.

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“…Misoprostol is available as an oral tablet, is inexpensive (USD 2.01/tablet) and can be kept at room temperature 4 6–8. Pharmacokinetic and clinical studies9 have shown that vaginal administration of misoprostol demonstrates better efficacy in TOP compared with oral administration 10. The common side effects are dose-dependent11 and include nausea, vomiting, diarrhoea, abdominal pain, chills and fever 11.…”

Section: Introductionmentioning

confidence: 99%