Vaginal mucoadhesive drug delivery systems

Pereira, Raphaela Regina de Araújo; Bruschi, Marcos Luciano

doi:10.3109/03639045.2011.623355

Cited by 106 publications

(76 citation statements)

References 53 publications

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“…Clotrimazole is, however, a very effective drug when used topically in the form of vaginal tablets, lozenges, ointments, creams, gels, and suppositories [1,4,5]. However, its low solubility is also a problem in the treatment of cutaneous diseases through a topical application of the drug.…”

Section: Clotrimazolementioning

confidence: 99%

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Karolewicz¹,

Gajda

Owczarek³

et al. 2014

Trop. J. Pharm Res

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Purpose: To evaluate the physicochemical properties of clotrimazole (CLT) solid dispersion with Pluronic F127 (PLU). Methods: Solid dispersions of the antifungal drug, clotrimazole, were prepared with Pluronic F127 using grinding (PM) and fusion (FUS) methods. Physicochemical characterization of the dispersions were performed using differential scanning calorimetry (DSC), x-ray powder diffraction (XRPD) and Fourier transform infrared spectroscopy (FTIR

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Section: Clotrimazolementioning

confidence: 99%

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Karolewicz¹,

Gajda

Owczarek³

et al. 2014

Trop. J. Pharm Res

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“…The different dosage forms of the vaginal route include solutions, suppositories, gels, foams, vaginal rings, tampons, sponges, creams, ointments, doushes, pessaries, soft gelatin capsules and tablets [215]. Recently, polymeric films have been considered as a novel dosage form in vaginal mucosal delivery.…”

Section: Polysaccharide-based Vaginal Mucoadhesive Systemsmentioning

confidence: 99%

“…Its diameter range from 2.1 to 5.0cm whiles its length range from 8.4 to 11.3cm. The walls of the vagina consist of three layers: the stratified squamous epithelial layer, the lamina propria, the muscular layer and the tunica adventitia made up areolar connective tissues [214,215] …”

Section: Vaginal Physiology and Anatomymentioning

confidence: 99%

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Boateng

Okeke²,

Khan³

2015

CPD

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There has been increased interest in novel drug delivery systems to be administered via mucosal routes as an alternative to the currently used traditional routes such as parenteral (injections) and oral routes of administration. This is due to the several advantages they offer including avoiding first pass metabolism in the liver for oral administration and local activity which avoids the need for high systemic doses. To achieve the foregoing objectives, bioadhesive vehicles are required that ensure prolonged residence time to achieve systemic bioavailability via substantial drug absorption or significant drug concentration for local action.The drug delivery system is also required to be non-deleterious to the site of application and be well tolerated by vulnerable groups such as paediatric and geriatric patients. These essential characteristics are mainly satisfied by naturally occurring polymers, including polysaccharide based polymers which have the advantage of biocompatibility, biodegradability and therefore safety. This review discusses various bioadhesive polymers of polysaccharide origin formulated into a variety of dosage forms for drug delivery via the body's mucosal (moist) surfaces including ocular, oral (buccal and sublingual), nasal, gastrointestinal and vaginal mucosa, as well as moist wound sites. The anatomy and / or physiology of each site, coupled with the unique challenges each poses, the strategies employed for ensuring therapeutic efficacy, as well as the current state of the art will also be covered.

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“…This is a bioadhesive gel, which delivers the spermicide into the cervix by using a dosing device specially designed for this purpose. It releases the trace effective spermicide slowly and continuously within 24h (94).…”

Section: Synthetic Polymers Poly Acrylic Acidmentioning

confidence: 99%

Intravaginal Delivery Approaches for Contraception: An Overview with Emphasis on Gels

Gupta

Prabha

2017

J Pharm Pharm Sci

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ABSTRACT-The rising population with grave ramifications for the future is a fundamental issue, demanding for newer and better contraceptive modalities. Also, in order to achieve the contraceptive purpose, the choice of the most suitable delivery system is of unquestionable importance. Out of all dosage forms, vaginal gel formulations present indubitable benefits for contraceptive administration. Therefore, this review summarizes the history of research in the field of vaginal delivery systems with special emphasis on the development of vaginal gels containing safer and more effective contraceptive agents.

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Vaginal mucoadhesive drug delivery systems

Abstract: We provide a review of several vaginal mucoadhesive DDS currently in developmental stages or available in the market, immunization via the vagina and special emphasis on the challenges and difficulties associated with delivery of drugs via the vaginal route.

Cited by 106 publications

References 53 publications

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Polysaccharide Based Formulations for Mucosal Drug Delivery: A Review

Intravaginal Delivery Approaches for Contraception: An Overview with Emphasis on Gels

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