Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Karolewicz, Bożena; Gajda, Maciej; Owczarek, Artur; Pluta, Janusz; Gòrniak, Agata

doi:10.4314/tjpr.v13i8.5

Cited by 26 publications

(20 citation statements)

References 11 publications

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“…20 The increased dissolution of drug from solid dispersions possibly be related to the decreased drug crystallinity or effective wetting of the reduced drug particles. [45][46][47][48] Coprocessing of ibuprofen with magnesium trisilicate for enhanced dissolution possibly be a promising approach for improvement of ibuprofen bioavailability. 47 …”

Section: In-vitro Release Of Ibuprofenmentioning

confidence: 99%

“…[45][46][47][48] Coprocessing of ibuprofen with magnesium trisilicate for enhanced dissolution possibly be a promising approach for improvement of ibuprofen bioavailability. 47 …”

Section: In-vitro Release Of Ibuprofenmentioning

confidence: 99%

“…15,16 Ball milling presents a greener route for many processes compared to the use of microwave and ultrasound as energy sources. Impact and attrition during ball milling can bring about changes in the crystal structure of the drug and can induce amorphization [17][18][19][20][21][22] and improve bioavailability. 23 Freeze drying is a standard process used to stabilize and store the drug products in the pharmaceutical industries.…”

Section: Introductionmentioning

confidence: 99%

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Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

Acharya¹,

Mishra²,

Sahoo³

et al. 2017

ACSi

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Assessment of interactions of ibuprofen and magnesium trisilicate after co-processing has been carried out by infrared spectroscopy. Dry-state ball-milling and, aqueous state kneading and freeze-drying were performed. FTIR spectroscopy of co-processed materials described acid-base reaction between the carboxylic acid containing ibuprofen to a significant extent. Increased absorbance of carboxylate peak accompanied by a consistently reduced absorbance of the carbonyl acid peak was evident. Absorbance of carboxylate peak was more in freeze-dried sample compared to milled product. Intermolecular hydrogen bonding between ibuprofen and magnesium trisilicate in the co-processed material has been suggested. Inhibition of crystal morphology has been noticed in the photomicrographs of both the products. DSC report has shown absence or significantly decreased melting endotherm representing almost complete amorphization of ibuprofen. Release of drug increased greatly after co-processing in comparison to crystalline ibuprofen. Freeze-dried samples have improved drug release more significantly compared to ball-milled samples.

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Section: In-vitro Release Of Ibuprofenmentioning

confidence: 99%

“…[45][46][47][48] Coprocessing of ibuprofen with magnesium trisilicate for enhanced dissolution possibly be a promising approach for improvement of ibuprofen bioavailability. 47 …”

Section: In-vitro Release Of Ibuprofenmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

Acharya¹,

Mishra²,

Sahoo³

et al. 2017

ACSi

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“…PVPK30 and HPMC 4000cps are widely accepted excipients for solid dosage forms; used in the preparation and stabilization of solid PAGE | 72 | dispersions [35][36][37][38][39]. Pluronic acid F 127(PLF 127) was investigated as carrier in the preparation of solid dispersions for its surfactant properties [40,41] The selection of hydrophilic carrier in the preparation of solid dispersions is based on number of factors such as method of preparation; for example PVP, HPMC and carbomers are not suitable carriers for hot melt method as these polymers are completely burn down at high temperature, hence suitable to be used in solvent evaporation method [42]. The other factor involved is the determination of drug solubility in the aqueous solution of the polymer [43].…”

Section: Introductionmentioning

confidence: 99%

Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

Sharma¹,

Middha²

2017

ijdd

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A b s t r a c tThe solid dispersions of indomethacin with hydrophilic polymers were prepared by lyophilization. The polymers used in the investigation were HPMC, PVP K30, CBR and PLF 127. The solubility and dissolution of indomethacin from prepared lyophilized solid dispersions were investigated in 0.1 N HCl, purified water and USP-NF dissolution media. Out of fifteen lyophilized formulations from F1 to F15, five formulations F2, F5, F8, F12 and F14 showed highest solubility in purified water. Formulation F2, F8 failed to comply with the USP-NF dissolution test for indomethacin capsules. Formulation F14 showed maximum dissolution in the respective dissolution media within 60 min. Sustained drug release was observed for 6 h with formulations F2 and F8 in USP-NF media. The formulations F2, F5, F8, F12 and F14 were characterized by modulated DSC and FT-IR spectroscopy. Some Formulations on stability testing were found physico-chemically stable at accelerated temperature conditions.

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“…It was recently shown by our group and other authors that Pluronic F127 can be used successfully as a carrier for dissolution rate improvement of poorly water-soluble drugs, including simvastatin (18) and ketoconazole (19)(20)(21)(22). The aim of this study was to increase acyclovir dissolution rate by preparing physical mixtures and solid dispersions of anhydrous acyclovir form I (ACV) with Pluronic F127 (PLU).…”

mentioning

confidence: 99%

Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method

et al. 2016

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The dissolution rate of anhydrous acyclovir was improved by the preparation of physical mixtures and solid dispersions with the non-ionic polymer Pluronic F127 using the kneading method at diff erent drug-to-polymer ratios. The obtained physical mixtures and solid dispersions were examined in terms of drug content and possible physical and chemical interactions between the drug and polymer using FTIR spectral studies, diff erential scanning calorimetry and powder X-ray diff raction analysis. The dissolution rate of acyclovir was determined using the rotating disk method. It was found that the minimal content of the polymer within the mixtures needed to increase the dissolution rate of the drug was 50 %.

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Physicochemical Characterization and Dissolution Studies of Solid Dispersions of Clotrimazole with Pluronic F127

Cited by 26 publications

References 11 publications

Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

Infrared spectroscopy for analysis of co-processed ibuprofen and magnesium trisilicate at milling and freeze drying

Investigations on noval method for the formulation of solid dispersions part- I Formulation, characterization and selection

Physicochemical characterization and dissolution studies of acyclovir solid dispersions with Pluronic F127 prepared by the kneading method

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