Vaginal misoprostol versus intravenous oxytocin for the management of second‐trimester pregnancies with intrauterine fetal death: A randomized clinical trial

Abediasl, Zhila; Sheikh, Mahdi; Pooransari, Parichehr; Farahani, Zahra; Kalani, F

doi:10.1111/jog.12910

Cited by 13 publications

(13 citation statements)

References 17 publications

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“…Women with stillbirth usually deliver vaginally unless otherwise there is an absolute indication for caesarean section [ 39 ]. Once the stillbirth is diagnosed there is higher chance to go for inducing labour to avoid complications [ 40 ]. Association of preterm birth with.stillbirth also noticed in our study like other studies [ 35 – 37 ].…”

Section: Discussionmentioning

confidence: 99%

Level, causes, and risk factors of stillbirth: a population-based case control study from Chandigarh, India

Newtonraj

Kaur

Gupta

et al. 2017

BMC Pregnancy Childbirth

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BackgroundGlobally, India ranks first in the absolute number of stillbirths. Hence, the level, causes, and risk factors of stillbirths were estimated to facilitate designing of prevention strategy.MethodsCapture and recapture method was used to identify 301 stillbirths from 1st July 2013 to 31st August 2014 in Chandigarh Union Territory of India. Verbal autopsies (n = 181) were done at household level to identify causes of stillbirths. Risk factors were determined using case-control approach. Women who had a stillbirth in the past 3 months were enrolled as cases (n = 181) and those who had live-birth in same neighbourhood were included as controls (n = 181). Statistical differences in the distribution of characteristics of cases and controls were tested by t test and chi square test respectively for quantitative and categorical variables. In logistic regression models adjusted odds ratios (aOR) and 95% confidence intervals (CIs) were estimated for various risk factors.ResultsStillbirth rate was estimated to be 16/1000 birth. Antepartum causes were more common (68%) than intrapartum causes (32%). Among maternal conditions, hypertension (18.2%) and chorio-amnionitis (13.8%), and among foetal conditions, growth restriction (19.9%) and congenital anomalies (18.8%) were the leading causes. In about half of the stillbirths foetal (48%) and maternal (44.7%) causes were unidentifiable. Risk factors of stillbirths were: higher maternal age (aOR 1.1, 95%CI 1.0–1.2), vaginal delivery (aOR 8.1, 95%CI 2.6–26), induced labour (aOR 2.6, 95%CI 1.5–4.5), green or light brown liquor (aOR 2.0, 95%CI 1.1–3.8), preterm delivery (aOR 6.4, 95%CI 3.7–11) and smaller household size (aOR 1.2, 95% CI 1.1–1.3).ConclusionsStillbirth rate was high in Chandigarh Union Territory of India. Major causes and risk factors amenable to interventions were infections, hypertension, congenital malformations, foetal growth restriction, pre-maturity and household size. Therefore, better maternity ante-natal and intra-natal care is required to achieve a single digit stillbirth rate.Electronic supplementary materialThe online version of this article (10.1186/s12884-017-1557-4) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Level, causes, and risk factors of stillbirth: a population-based case control study from Chandigarh, India

Newtonraj

Kaur

Gupta

et al. 2017

BMC Pregnancy Childbirth

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“…Indikasi ketuban pecah dini (KPD) pada penelitian ini juga menggunakan induksi Misoprostol. Induksi persalinan dengan Misoprostol pada kasus KPD mayoritas memberikan keberhasilan persalinan dengan metode persalinan normal [36]. Keberhasilan Misoprostol dinilai lebih baik daripada Oksitosin karena Oksitosin hanya bekerja dengan meningkatkan kontraktilitas rahim dengan cara memengaruhi otot miometrium tanpa efek pematangan serviks [28,37].…”

Section: Indikasi Yang Memerlukan Induksi Persalinanunclassified

“…Terdapat beberapa penelitian yang menyatakan bahwa penggunaan Misoprostol efektif dan aman untuk induksi persalinan pada kejadian IUFD [38][39][40]. Mayoritas pasien dapat melahirkan secara normal setelah diinduksi menggunakan Misoprostol daripada menggunakan induksi Oksitosin [36]. Onset Misoprostol sebagai induksi persalinan dinilai lebih cepat dengan komplikasi yang lebih sedikit dibandingkan dengan Oksitosin [36].…”

Section: Indikasi Yang Memerlukan Induksi Persalinanunclassified

“…Mayoritas pasien dapat melahirkan secara normal setelah diinduksi menggunakan Misoprostol daripada menggunakan induksi Oksitosin [36]. Onset Misoprostol sebagai induksi persalinan dinilai lebih cepat dengan komplikasi yang lebih sedikit dibandingkan dengan Oksitosin [36]. Jika dibandingkan dengan PGE2 (Dinoprostone), selain onset yang lebih cepat Misoprostol juga menghasilkan pematangan serviks yang lebih baik [29].…”

Section: Indikasi Yang Memerlukan Induksi Persalinanunclassified

“…Misoprostol yang diberikan secara vaginal berhasil menginduksi persalinan pada wanita dengan IUFD lebih singkat dan dengan efek samping yang lebih sedikit dibandingkan dengan pemberian Misoprostol secara oral [9,36]. Penggunaan Misoprostol secara vaginal dinyatakan aman dan efektif untuk mengakhiri kehamilan pada kasus IUFD yang terjadi pada saat umur kehamilan berada pada trimester 2 dan 3 [40,41].…”

Section: Off-label Rute Pemberian Misoprostolunclassified

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Penggunaan Off-Label Misoprostol Pada Pasien Obstetri-Ginekologi Di Rumah Sakit Swasta Kab. Banyumas

et al. 2021

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Penggunaan obat off-label pada pasien obstetri-ginekologi memerlukan kewaspadaan karena berisiko tinggi bagi kehamilan. Meskipun masih terjadi perdebatan, data profil penggunaannya pada praktik klinik masih kurang. Penelitian ini bertujuan untuk mengobservasi penggunaan obat off-label pada pasien obstetri dan ginekologi di rumah sakit swasta, khususnya obat Misoprostol. Penelitian ini menggunakan pendekatan deskriptif observasional terhadap data rekam medis rumah sakit. Pengambilan data penelitian secara retrospektif di RSU Bunda (RS X) periode Juli 2017 – Desember 2017 dan RS Sinar Kasih (RS Y) periode Januari 2018 – Desember 2018. Jumlah sampel ditentukan menggunakan rumus Slovin, dengan teknik sampling systematic random sampling di RS X dan total sampling di RS Y. Jumlah keseluruhan sampel adalah 220 RM di RS X 130 dan RS Y 90. Penelitian dilakukan pada rentang waktu bulan Januari 2019 – Maret 2019. Hasil dianalisis secara univariat menggunakan beberapa referensi terkait. Hasil penelitian menunjukan adanya penggunaan obat off-label misoprostol sebanyak 26,92% di RS X dan sebanyak 4% di RS Y. Obat off-label yang ditemukan adalah Misoprostol yang tergolong ke dalam kategori off-label indikasi (Missed Abortion, Abortus Incomplete, Blighted Ovum, dan Induksi persalinan pada kasus Serotinus, KPD, dan IUFD), off-label dosis (50 µg, 100 µg dan 400 µg), dan off-label rute pemberian (sublingual dan vaginal).

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Medical treatment for early fetal death (less than 24 weeks)

Lemmers

Verschoor

Kim

et al. 2019

Cochrane Database of Systematic Reviews

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Vaginal misoprostol versus intravenous oxytocin for the management of second‐trimester pregnancies with intrauterine fetal death: A randomized clinical trial

Abstract: Both vaginal misoprostol and high-dose i.v. oxytocin are highly effective in labor induction in second-trimester pregnancies with IUFD and an unripe cervix. However, vaginal misoprostol seems to be superior to i.v. oxytocin.

Cited by 13 publications

References 17 publications

Level, causes, and risk factors of stillbirth: a population-based case control study from Chandigarh, India

Level, causes, and risk factors of stillbirth: a population-based case control study from Chandigarh, India

Penggunaan Off-Label Misoprostol Pada Pasien Obstetri-Ginekologi Di Rumah Sakit Swasta Kab. Banyumas

Medical treatment for early fetal death (less than 24 weeks)

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