Vaginal
            <i>Lactobacillus</i>
            Flora of Healthy Swedish Women

Vásquez, Alejandra; Jakobsson, Tell; Ahrné, Siv; Forsum, Urban; Molin, Göran

doi:10.1128/jcm.40.8.2746-2749.2002

Cited by 283 publications

(258 citation statements)

References 28 publications

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“…Our results are in general agreement with other studies (17,19,20) showing that only one or a few Lactobacillus species colonize the healthy human vagina (1.94 species/individual) and that species within the L. acidophilus complex predominate (L. crispatus). Antonio et al (21) (20) found that L. crispatus was the only Lactobacillus species linked to a single grade (as determined by Gram stain-based grading of vaginal smears), namely grade Ia, while the other lactobacilli were more evenly distributed over all specimens.…”

Section: Discussionsupporting

confidence: 83%

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Identification and in vitro production of Lactobacillus antagonists from women with or without bacterial vaginosis

Branco

Nardi

Moreira

et al. 2010

Braz J Med Biol Res

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Section: Discussionsupporting

confidence: 83%

“…Additionally, some Lactobacillus species, such as L. iners, do not grow on Rogosa or MRS media traditionally used for lactobacillus recovery (16). This species seems to be dominant both among white (17) and black women (18). However, due to its culture characteristic (growth only on blood agar), its antagonistic ability is not known.…”

Section: Discussionmentioning

confidence: 99%

Identification and in vitro production of Lactobacillus antagonists from women with or without bacterial vaginosis

Branco

Nardi

Moreira

et al. 2010

Braz J Med Biol Res

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“…iners is the predominant component of the vaginal microbiota in a significant proportion of healthy women (5,6,30,31). There is no clinical evidence to date that the presence of L. iners is associated with induction of discharge, inflammation, or discomfort.…”

mentioning

confidence: 99%

At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1

Macklaim

Gloor²,

Anukam

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

194

191

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Lactobacilli have long been regarded as important constituents of the healthy human vagina. Lactobacillus iners is the most frequently detected bacterial species in the vagina, but little is known about its characteristics. We report a description of the whole-genome sequence of L. iners AB-1 along with comparative analysis of published genomes of closely related strains of lactobacilli. The genome is the smallest Lactobacillus reported to date, with a 1.3-Mbp single chromosome. The genome seems to have undergone one or more rapid evolution events that resulted in large-scale gene loss and horizontal acquisition of a number of genes for survival in the vagina. L. iners may exhibit specialized adaptation mechanisms to the vaginal environment, such as an iron–sulfur cluster assembly system, and several unique σ factors to regulate gene transcription in this fluctuating environment. A potentially highly expressed homolog of a cholesterol-binding lysin may also contribute to host cell adhesion or act as a defense mechanism against other microbes. Notably, there is a lack of apparent adhesion proteins, but several cell-anchor proteins were identified and may be important for interaction with the host mucosal tissues. L. iners is widely present in healthy females as well as those suffering from bacterial vaginosis or who have undergone antimicrobial therapy, suggesting that it is an important indigenous species of the vagina.

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“…Первые данные о выделении L. iners у женщин без признаков нарушения микрофлоры вла-галища появились в 2002 г. [14]. Дальнейшие исследования показали, что данный вид часто встречается при БВ, обнаруживается у женщин с антенатальными потерями плода в анамнезе [15,16].…”

Section: вагинальный микробиомunclassified

Current views on vaginal microbiota and its impact on pregnancy outcomes

Siniakova

Александровна

2017

Z.akus.zen.bolezn

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ВведениеНевынашивание беременности -основ-ная причина перинатальной заболеваемости и смертности во всем мире и одна из важ-нейших проблем практического акушерства.Согласно данным ВОЗ частота встречаемости данной патологии в разных странах остается стабильно высокой и составляет 10-25 % от всех выявленных беременностей (20-25 % -самопроизвольные выкидыши, 5-10 % -пре- ■ Дисбиоз влагалища -одна из ведущих причин неблагоприятных исходов беременности. Основная роль в под-держании постоянства микробиоценоза влагалища принадлежит лактобациллам. Инфекционный процесс мо-гут вызвать как патогенные, так и условно-патогенные микроорганизмы, однако в подавляющем большинстве случаев возбудителями генитальной инфекции являются представители нормальной микрофлоры. Нарушение микробиоценоза влагалища в сочетании с несостоятельностью цервикального барьера ведет к миграции бак-терий в амниотическую полость и запуску патологических механизмов, приводящих к прерыванию беремен-ности. В статье представлены современные данные о роли инфекционного фактора в генезе невынашивания беременности. Рассмотрен вопрос о способности Lactobacillus iners предрасполагать к развитию патологической влагалищной микрофлоры. Уделено внимание основным подходам к профилактике и лечению дисбиотических нарушений. Затронут вопрос о применении бактериофагов в акушерстве и гинекологии.■ Ключевые слова: микробиоценоз влагалища; преждевременные роды; самопроизвольный выкидыш; бактери-альный вагиноз; аэробный вагинит. CURRENT VIEWS ON VAGINAL MICROBIOTA AND ITS IMPACT ON PREGNANCY OUTCOMES © A.A. SiniakovaThe ■ Vaginal dysbiosis is one of the leading causes of adverse pregnancy outcomes. The main role in maintaining the constancy of vaginal microbiocenosis belongs to lactobacilli. The infection process can be caused by both pathogenic and opportunistic microorganism, however, in the vast majority of cases vaginal infections is associated with the normal microflora. Violation of microbiocenosis of the vagina in combination with a cervical barrier failure leads to migration of bacteria in the amniotic cavity and the launch of the pathological mechanisms leading to pregnancy loss. The paper presents current data on the influence of vaginal infection on pregnancy loss. Consider the ability of Lactobacillus iners predispose to the development of pathological vaginal microflora. Attention was paid to the basic approaches to prevention and treatment of dysbiotic disorders. Discussion on the use of bacteriophages in obstetrics and gynecology.

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Vaginal Lactobacillus Flora of Healthy Swedish Women

Abstract: Species of the

Cited by 283 publications

References 28 publications

Identification and in vitro production of Lactobacillus antagonists from women with or without bacterial vaginosis

Identification and in vitro production of Lactobacillus antagonists from women with or without bacterial vaginosis

At the crossroads of vaginal health and disease, the genome sequence of Lactobacillus iners AB-1

Current views on vaginal microbiota and its impact on pregnancy outcomes

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