Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations

Richardson, Julie; Armstrong, Tom

doi:10.1201/b14099-22

Cited by 12 publications

(6 citation statements)

References 2 publications

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“…Bioadhesive polymers that have been used for intravaginal formulations include polycarbophil, hydroxypropylcellulose and polyacrylic acid (70). The first bioadhesive systems for vaginal drug delivery were in the form of tablets for the delivery of bleomycin, an anti-caner agent (70)(71)(72)(73)(74)(75). Attempts have also been made to delivery of microbicides using bioadhesive microparticulate vaginal systems (73)(74)(75)(76)(77)(78)99).…”

Section: Bioadhesive Intravaginal Systemsmentioning

confidence: 99%

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

et al. 2008

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Abstract. The objective of this review is to describe the current status of several intravaginal anti-HIV microbicidal delivery systems these delivery systems and microbicidal compounds in the context of their stage within clinical trials and their potential cervicovaginal defence successes. The global Human Immuno-Deficiency Virus (HIV) pandemic continues to spread at a rate of more than 15,000 new infections daily and sexually transmitted infections (STIs) can predispose people to acquiring HIV infection. Male-to-female transmission is eight times more likely to occur than female-to-male transmission due to the anatomical structure of the vagina as well as socio-economic factors and the disempowerment of women that renders them unable to refuse unsafe sexual practices in some communities. The increased incidence of HIV in women has identified the urgent need for efficacious and safe intravaginal delivery of anti-HIV agents that can be used and controlled by women. To meet this challenge, several intravaginal anti-HIV microbicidal delivery systems are in the process of been developed. The outcomes of three main categories are discussed in this review: namely, dual-function polymeric systems, non-polymeric systems and nanotechnology-based systems. These delivery systems include formulations that modify the genital environment (e.g. polyacrylic acid gels and lactobacillus gels), surfactants (e.g. sodium lauryl sulfate), polyanionic therapeutic polymers (e.g. carageenan and carbomer/lactic acid gels), proteins (e.g. cyanovirin-N, monoclonal antibodies and thromspondin-1 peptides), protease inhibitors and other molecules (e.g. dendrimer based-gels and the molecular condom). Intravaginal microbicide delivery systems are providing a new option for preventing the transmission of STIs and HIV.

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Section: Bioadhesive Intravaginal Systemsmentioning

confidence: 99%

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

et al. 2008

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“…The combination of the sheep model and the gamma scintigraphy method has been proved to be an extremely useful tool for evaluating the distribution, spreading, and clearance of administered stomach mucoadhesive microspheres. [49] The surface morphology of microspheres and the morphological changes produced through polymer degradation can be investigated and documented using scanning electron microscopy (SEM), electron microscopy, and scanning tunneling microscopy (STM). To assess the effect of surface morphology on the mucoadhesive properties, the microsphere samples are lyophilized and analyzed under SEM at 150 3 and 1000 3.…”

Section: Measurement Of the Residence Time/in Vivo Techniquesmentioning

confidence: 99%

“…Mucoadhesives labeled with Cr-51, Tc-99m, In-113m, or I-123 have been used to study the transit of the microspheres in the GI tract. [49] Distribution and retention time of the mucoadhesive microspheres can be studied using the gamma scintigraphy technique. A study has reported the intensity and distribution of radioactivity in the genital tract after administration of technetium-labeled HYAFF microspheres.…”

Section: Measurement Of the Residence Time/in Vivo Techniquesmentioning

confidence: 99%

See 1 more Smart Citation

Stomach-specific mucoadhesive microsphere as a controlled drug delivery system

Rajput¹,

Majmudar²,

Patel³

et al. 2010

Syst Rev Pharm

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“…The use of mucoadhesive polymers for the development of delivery system helps in increasing the migration of the drug to target site, thereby promoting better therapeutic efficacy 29 . The polymers used in the development of vaginal and rectal delivery systems include mucin, gelatin, polycarbophil and poloxamer [30][31][32] . These polymers are able to swell rapidly when placed in aqueous environment and therefore exhibiting a controlled drug release [34][35][36] .…”

mentioning

confidence: 99%

Untitled

Senthil

Harsha

Moteriya

et al. 2017

IJPSR

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ABSTRACT:The aim of the present investigation was to prepare and evaluate novel bioadhesive vaginal microspheres containing Terbinafine (TBH) in order to provide long-term therapeutic activity at the site of infection and prove the same using in vitro anti fungal activity of the same using Candida albicans. Microspheres were prepared by the Solvent extraction technique using sodium hyaluronate and Arlacel A. Microspheres were characterized by SEM, DSC, FTIR, particle size analysis and evaluated for percentage yield, drug loading, encapsulation efficiency and in vitro drug release. FTIR and DSC studies showed that no chemical changes or alterations occurred in the drug and polymers. The sphericity factor indicated that the prepared microspheres were spherical. Formulation (TBHMs) indicated a controlled in vitro drug release and good bioadhesive strength. The in vitro anti fungal activity confirmed for a controlled and prolonged capacity of the prepared novel formulation. The results indicated that this drug delivery system can be explored for controlled intra-vaginal drug release.

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Vaginal Delivery of Calcitonin by Hyaluronic Acid Formulations

Cited by 12 publications

References 2 publications

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

A Review of Current Intravaginal Drug Delivery Approaches Employed for the Prophylaxis of HIV/AIDS and Prevention of Sexually Transmitted Infections

Stomach-specific mucoadhesive microsphere as a controlled drug delivery system

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