Stomach-specific mucoadhesive microsphere as a controlled drug delivery system

Rajput, Ganesh C.; Majmudar, Falguni; Patel, Jayvadan; R, Thakor; Nb, Rajgor

doi:10.4103/0975-8453.59515

Cited by 57 publications

(44 citation statements)

References 29 publications

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“…Mucoadhesive tablets are widely used because they release the drug for prolong period, reduce frequency of drug administration and improve the patient compliance. 9 The mucoadhesive drug delivery system may include the following: 9  Gastrointestinal delivery system  Sublingual delivery system  Vaginal delivery system  Nasal delivery system  Ocular delivery system  Rectal delivery system  Buccal delivery system…”

Section: Fig 4: In Situ Formation Of Floating Gelmentioning

confidence: 99%

Untitled

2017

IJPSR

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ABSTRACT:Oral drug delivery is the most preferred route for the various drug molecules among all other routes of drug delivery, because ease of administration which lead to better patient compliance. So, oral extended release drug delivery system becomes a very promising approach for those drugs that are given orally but having the shorter halflife and high dosing frequency. Extended release drug delivery system which reduce the dosing frequency of certain drugs by releasing the drug slowly over an extended period of time. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract. The purpose of writing this review was to compile recent literature on pharmaceutical approaches used in enhancing the Gastric Residence Time (GRT). Enhancing the GRT may explore new potentials of stomach as drug-absorbing organ. Several approaches are currently used including Floating drug delivery system, Matrix tablet, pulsatile drug delivery, In situ gel, Stomach specific Mucoadhesive tablets and Microsponge.

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Section: Fig 4: In Situ Formation Of Floating Gelmentioning

confidence: 99%

Untitled

2017

IJPSR

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“…stomach and small intestine. This is due to the relatively short transit time of the dosage forms in these anatomical segments [1] . Thus, after only a short period of less than 6 h, the CR-DF has already left the upper gastrointestinal tract and the drug is released in non absorbing distal segments of the gastrointestinal tract.…”

Section: Imentioning

confidence: 99%

Development and in-vitro evaluation of mucoadhesive gastroretentive matrix tablets of cephalexin

Yadav¹

2013

IOSR-JPBS

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“…Customarily, in these systems mucoadhesive polymers adhere to the mucin layer on the mucosal epithelium followed by a decrease in drug clearance rate from the GI absorption site, thereby increasing the time available for drug absorption [Rajput et al, 2010]. Polymers used in such system may have natural or synthetic origin.…”

Section: Polymers Used For Mucoadhesive Drug Deliverymentioning

confidence: 99%