Vaginal colonization by Candida in asymptomatic women with and without a history of recurrent vulvovaginal candidiasis

Giraldo, Paulo César; Nowaskonski, Angele von; Gomes, Francis A. M.; Linhares, Iara M.; Neves, Neuza Maria Alcântara; Witkin, Steven S.

doi:10.1016/s0029-7844(99)00577-3

Cited by 59 publications

(25 citation statements)

References 13 publications

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“…34,35 In this situation, the epithelial cells no longer tolerate it and produce chemotactic factors to attract neutrophils to the vagina, thus ending the fungus commensalism relationship and triggering a symptomatic response. 34,35 In this situation, the epithelial cells no longer tolerate it and produce chemotactic factors to attract neutrophils to the vagina, thus ending the fungus commensalism relationship and triggering a symptomatic response.…”

Section: Discussionmentioning

confidence: 99%

Identification of Immune Cells by Flow Cytometry in Vaginal Lavages from Women with Vulvovaginitis and Normal Microflora

Giraldo

Carvalho

Amaral³

et al. 2011

American J Rep Immunol

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Section: Discussionmentioning

confidence: 99%

Identification of Immune Cells by Flow Cytometry in Vaginal Lavages from Women with Vulvovaginitis and Normal Microflora

Giraldo

Carvalho

Amaral³

et al. 2011

American J Rep Immunol

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“…[18][19][20] Polymerase chain reaction is currently of use only as a research tool. [21][22][23] Antifungal sensitivities There is no proved utility of antifungal sensitivity testing for complicated VVC 24 (evidence level III, recommendation grade B). It is possibly indicated for women with a chronic immunological abnormality 25 (evidence level III, recommendation grade B); or repeated isolation of a non-albicans yeast 26 27 (evidence level IV, recommendation grade C).…”

Section: Processing Of Samplesmentioning

confidence: 99%

Vulvovaginal candidiasis

White

Vanthuyne

2006

Sexually Transmitted Infections

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“…Candida microorganisms, especially Candida albicans , often colonize the genital tract in women, and under certain conditions are responsible for mucosal inflammation (Hurley, 1977; Fleury, 1981; Odds, 1988; Fidel and Sobel, 1996; Giraldo et al, 2000; Sobel, 2007). Vulvovaginal candidiasis (VVC) is a frequent consequence of Candida infection, accompanied by variable pruritus, soreness, rash, and vaginal discharge, with patients experiencing a strong discomfort.…”

Section: Introductionmentioning

confidence: 99%

Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis

Rosentul¹,

Delsing²,

Jaeger³

et al. 2014

Front. Microbiol.

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Objective: Approximately 5% of women suffer from recurrent vulvovaginal candidiasis (RVVC). It has been hypothesized that genetic factors play an important role in the susceptibility to RVVC. The aim of this study was to assess the effect of genetic variants of genes encoding for pattern recognition receptors (PRRs) on susceptibility to RVVC.Study design: For the study, 119 RVVC patients and 263 healthy controls were recruited. Prevalence of polymorphisms in five PRRs involved in recognition of Candida were investigated in patients and controls. In silico and functional studies were performed to assess their functional effects.Results: Single nucleotide polymorphisms (SNPs) in TLR1, TLR4, CLEC7A, and CARD9 did not affect the susceptibility to RVVC. In contrast, a non-synonymous polymorphism in TLR2 (rs5743704, Pro631His) increased the susceptibility to RVVC almost 3-fold. Furthermore, the TLR2 rs5743704 SNP had deleterious effects on protein function as assessed by in silico analysis, and in vitro functional assays suggested that it reduces production of IL-17 and IFNγ upon stimulation of peripheral blood mononuclear cells with Candida albicans. No effects were observed on serum mannose-binding lectin concentrations.Condensation: This study demonstrates the association of susceptibility to RVVC with genetic variation in TLR2, most likely caused by decreased induction of mucosal antifungal host defense.Conclusion: Genetic variation in TLR2 may significantly enhance susceptibility to RVVC by modulating host defense mechanisms against Candida. Additional studies are warranted to assess systematically the role of host genetic variation for susceptibility to RVVC.

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Vaginal colonization by Candida in asymptomatic women with and without a history of recurrent vulvovaginal candidiasis

Cited by 59 publications

References 13 publications

Identification of Immune Cells by Flow Cytometry in Vaginal Lavages from Women with Vulvovaginitis and Normal Microflora

Identification of Immune Cells by Flow Cytometry in Vaginal Lavages from Women with Vulvovaginitis and Normal Microflora

Vulvovaginal candidiasis

Gene polymorphisms in pattern recognition receptors and susceptibility to idiopathic recurrent vulvovaginal candidiasis

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