Vagina

Robboy, Stanley J.; Russell, Peter

doi:10.1016/b978-0-443-07477-6.50010-x

Cited by 9 publications

(9 citation statements)

References 135 publications

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“…Differential diagnoses of primary ovarian carcinoid include metastatic carcinoid, granulosa cell tumours, poorly differentiated primary or metastatic adenocarcinoma, Brenner tumours and androblastoma [ 2 ] [13]. Approximately 5% of primary carcinoid tumours of the non-mucinous type have a malignant clinical course, but so far there are no histological parameters that can predict malignancy [ 2 ] [ 9 ]. Insular carcinoids are among the tumours with low malignant potential.…”

Section: Discussionmentioning

confidence: 99%

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Ovarian Strumal Carcinoid Tumour: Case Report

Antovska

Krstevska

Trajanova

et al. 2018

Open Access Maced J Med Sci

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BACKGROUND:Ovarian strumal carcinoid is a germ cell tumour characterised by a mixture of thyroid tissue and carcinoid. Ovarian struma is a very rare occurrence with 0.3-1% incidence of all ovarian tumours and 3% of mature teratomas. Primary carcinoid ovarian tumours are still uncommon as a part of mature teratoma or mucinous cystadenoma. There are four major variants of a carcinoid tumour: insular, trabecular, strumal and mucinous. A strumal carcinoid is an unusual form of ovarian teratoma composed of an intimate admixture of thyroid/carcinoid tissues.CASE REPORT:This is a case report of a 59-year old woman with a 5-year clinical history of perimenopausal uterine bleeding and three explorative curettages. Gynaecological and ultrasound examinations revealed ovarian enlargement with a diameter of 50 mm with hypoechoic zones suspected of benign teratoma. The diagnostic test such as Ca-125, AFP, free-T4 and TSH was in normal range. A smooth, solid right ovarian 50 an mm-size tumour, as well as small amount of fluid in the Douglas pouch, was found during the total abdominal hysterectomy, bilateral salpingo-oophorectomy and staging biopsy. The histopathology revealed teratoma with strumal carcinoid tumour IA stage according to AJCC 2010 of the right ovary and negative cytopathology of the fluid from the Douglas pouch. On the postoperative 2-year control, the patient was tumour free, and Ca-125, free-T4 and TSH were in normal range.CONCLUSION:We would like to point out those specific diagnostic tools, such as ultrasound and Ca-125 have low specificity and sensitivity in detection of this rare ovarian malignancy.

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Section: Discussionmentioning

confidence: 99%

“…Insular carcinoids are among the tumours with low malignant potential. Cases of strumal carcinoid metastases which consist of both the carcinoid and thyroidal type are rarely reported [ 9 ]. Mucinous carcinoids tend to be more aggressive in the clinical course.…”

Section: Discussionmentioning

confidence: 99%

Ovarian Strumal Carcinoid Tumour: Case Report

Antovska

Krstevska

Trajanova

et al. 2018

Open Access Maced J Med Sci

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“…Microscopically, primary OCTs present a variety of patterns, including insular, trabecular, strumal and mucinous. 10 A mixed type has also been reported, which is composed of any combination of the pure types. Primary ovarian carcinoids also arise in association with mucinous tumors; therefore, a preoperative diagnosis is extremely difficult.…”

Section: Discussionmentioning

confidence: 99%

Primary ovarian carcinoid tumor: a report of 4 cases

Salhi¹,

Laamouri²,

Boujelbène³

et al. 2017

Int Surg J

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Ovarian carcinoid tumor is a rare neoplasm that account for 0.3% of all ovarian tumors. It is commonly seen in perimenopausal and postmenopausal women. The aim of this study is to investigate the clinical features and to evaluate the treatment of this rare tumor. The study reviewed retrospectively the clinical and pathological findings of 4 cases of primary OCT treated in Salah Azaiez Institute between 1994 and 2012. The median age was 50 years (ranging from 28 to 75 years). All the patients underwent radical surgery. Two patients had carcinoid tumors occurring in mature cystic teratoma. Three patients had stage I diseases, and one patient had stage III disease, this patient had adjuvant chemotherapy. The follow up median was 23 months. There was one case of bone and lung metastasis diagnosed in the patient who had stage III disease, fourteen months after the surgery but the patient died of her disease four month later. The other patients were alive without evidence of disease recurrence. Primary Ovarian carcinoid tumors are most of the time associated with good clinical results. Surgical excision of the tumor is usually sufficient treatment for most of the patients

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“…Ovarian carcinoma (OC) makes up 90% of all ovarian cancers [ 1 ] and is the leading cause of gynecological cancer death in Western countries [ 2 ]. Two thirds of OC patients present with metastases at diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status

et al. 2011

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Endoglin (CD105), a cell surface co-receptor for transforming growth factor-β, is expressed in proliferating endothelial cells, as well as in cancer cells. We studied endoglin expression and its clinical relevance in effusions, primary tumors, and solid metastatic lesions from women with advanced-stage ovarian serous carcinoma. Endoglin expression was analyzed by immunohistochemistry in effusions (n = 211; 174 peritoneal, 37 pleural). Cellular endoglin staining was analyzed for association with the concentration of soluble endoglin (previously determined by ELISA) in 95 corresponding effusions and analyzed for correlation with clinicopathologic parameters, including survival. Endoglin expression was additionally studied in 34 patient-matched primary tumors and solid metastases. Carcinoma and mesothelial cells expressed endoglin in 95/211 (45%) and 133/211 (63%) effusions, respectively. Carcinoma cell endoglin expression was more frequent in effusions from patients aged ≤60 years (p = 0.048) and in post- compared to prechemotherapy effusions (p = 0.014), whereas mesothelial cell endoglin expression was higher in prechemotherapy effusions (p = 0.021). No association was found between cellular endoglin expression and its soluble effusion concentration. Endoglin was expressed in 17/34 (50%) primary tumors and 19/34 (56%) metastases, with significantly higher percentage of immunostained cells in solid metastases compared to effusions (p = 0.036). Endoglin expression did not correlate with survival. Tumor cell endoglin expression is higher in post- vs. prechemotherapy effusions, whereas the opposite is seen in mesothelial cells. Together with its upregulation in solid metastases, this suggests that the expression and biological role of endoglin may differ between cell populations and change along tumor progression in ovarian carcinoma.

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Vagina

Cited by 9 publications

References 135 publications

Ovarian Strumal Carcinoid Tumour: Case Report

Ovarian Strumal Carcinoid Tumour: Case Report

Primary ovarian carcinoid tumor: a report of 4 cases

Endoglin (CD105) expression in ovarian serous carcinoma effusions is related to chemotherapy status

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