2015
DOI: 10.1016/j.cell.2015.03.022
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Vagal Sensory Neuron Subtypes that Differentially Control Breathing

Abstract: SUMMARY Breathing is essential for survival and under precise neural control. The vagus nerve is a major conduit between lung and brain required for normal respiration. Here, we identify two populations of mouse vagus nerve afferents (P2ry1, Npy2r), each a few hundred neurons, that exert powerful and opposing effects on breathing. Genetically guided anatomical mapping revealed that these neurons densely innervate the lung and send long-range projections to different brainstem targets. Npy2r neurons are largely… Show more

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Cited by 310 publications
(387 citation statements)
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References 48 publications
(75 reference statements)
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“…To overcome these obstacles, we used the bilateral delivery of an shRNA-expressing viral vector into the NG to accomplish an inducible molecular manipulation of VAN function in adult rats. To our knowledge, NG injection has so far been limited to nonsurvival administration of compounds for electrophysiological recordings (24) and, more recently, to the unilateral delivery of viral tracers and optogeneticsrelated tools (25). Here, we demonstrate that bilateral NG injection of a viral-mediated shRNA yields a specific and long-lasting reduction of GLP-1R expression in the VANs.…”
Section: Discussionmentioning
confidence: 77%
“…To overcome these obstacles, we used the bilateral delivery of an shRNA-expressing viral vector into the NG to accomplish an inducible molecular manipulation of VAN function in adult rats. To our knowledge, NG injection has so far been limited to nonsurvival administration of compounds for electrophysiological recordings (24) and, more recently, to the unilateral delivery of viral tracers and optogeneticsrelated tools (25). Here, we demonstrate that bilateral NG injection of a viral-mediated shRNA yields a specific and long-lasting reduction of GLP-1R expression in the VANs.…”
Section: Discussionmentioning
confidence: 77%
“…Ultimately, a more detailed phenotypic and functional characterization of these afferents and their central connections will require genetic approaches similar to those recently implemented for the study of cutaneous and vagal afferents (Abraira and Ginty, 2013; Chang et al, 2015). The projections from lamina I to the brainstem convey multiple modalities of interoceptive and exteroceptive information, and the challenge remains to identify which particular neurons relay inputs from muscle afferents that are relevant to exercise hyperpnea.…”
Section: Discussionmentioning
confidence: 99%
“…Identifying selective patterns of afferent vagus nerve activity (neurograms) in response to different cytokines, including IL-1β and TNF, is an important first step toward addressing these questions (37). This line of research may further benefit from molecular tools recently used to perform genetic molecular profiling of vagal afferents with a role in pulmonary and gastrointestinal regulation (133, 134). Brain neuronal activation (c-Fos) following intestinal infection with C. jejuni has been detected in the NTS, the area postrema, the ventrolateral medulla, the LC, the thalamus, different hypothalamic nuclei, the amygdala, and the insular cortex (54).…”
Section: The Role Of the Central Nervous Systemmentioning
confidence: 99%