“…In addition, other brain regions have been implicated in GLP-1-mediated modification of appetite and food intake, including the lateral parabrachial nucleus (16), lateral and dorsomedial hypothalamus (13), ventral tegmental area, and nucleus accumbens, all of which may be affected by the DREADD-driven activation of the hindbrain GCG neurons. These actions likely complement the ability of peripherally derived GLP-1 to produce satiety, acting at vagal afferents (6). Conditioned taste aversion, meanwhile, could not be recapitulated with DREADD-driven activation of GCG neurons (18,19,24).…”