Vacuum pouch microfluidic system and its application for thin-film micromixers

Lee, Cheng-Je; Hsu, Yu-Hsiang

doi:10.1039/c8lc01286e

Cited by 13 publications

(6 citation statements)

References 27 publications

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“…The VPM micromixer was designed by embedding a thin-film micromixer with curved microchannel in a polypropylene vacuum pouch. After piercing the vacuum pouch, fluids (reagents) are absorbed into the micromixer due to pressure difference between the atmospheric pressure and the negative pressure released from the previous vacuum system, initiating the mixing process [ 69 ]. PDMS thin film patterned with microchannels rolled around a core, using plasma bonding, formed an out-of-plane (3D) single- and double-spiral microchannel with very good performances for heat sink and heat exchanging applications [ 70 ].…”

Section: Mems Type Devices Based On Magnetic Polymer Filmsmentioning

confidence: 99%

Microelectromechanical Systems Based on Magnetic Polymer Films

et al. 2022

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Microelectromechanical systems (MEMS) have been increasingly used worldwide in a wide range of applications, including high tech, energy, medicine or environmental applications. Magnetic polymer composite films have been used extensively in the development of the micropumps and valves, which are critical components of the microelectromechanical systems. Based on the literature survey, several polymers and magnetic micro and nanopowders can be identified and, depending on their nature, ratio, processing route and the design of the device, their performances can be tuned from simple valves and pumps to biomimetic devices, such as, for instance, hearth ventricles. In many such devices, polymer magnetic films are used, the disposal of the magnetic component being either embedded into the polymer or coated on the polymer. One or more actuation zones can be used and the flow rate can be mono-directional or bi-directional depending on the design. In this paper, we review the main advances in the development of these magnetic polymer films and derived MEMS: microvalve, micropump, micromixer, microsensor, drug delivery micro-systems, magnetic labeling and separation microsystems, etc. It is important to mention that these MEMS are continuously improving from the point of view of performances, energy consumption and actuation mechanism and a clear tendency in developing personalized treatment. Due to the improved energy efficiency of special materials, wearable devices are developed and be suitable for medical applications.

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Section: Mems Type Devices Based On Magnetic Polymer Filmsmentioning

confidence: 99%

Microelectromechanical Systems Based on Magnetic Polymer Films

et al. 2022

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“…145 Alternatively, where practical, devices composed of gas permeable materials, such as PDMS can be degassed prior to loading directly. [146][147][148] This bulk degassing can be used as a means of fluidic actuation, or to remove bubbles by directly absorbing gas into permeable channel walls, and where this method is practical, it is an effective means of bubble-free loading dead-ended geometries. 149 The removal or prevention of spontaneously formed bubbles is critical to ensure long-term device operation.…”

Section: Design and Experimental Considerations For Hemocompatible MImentioning

confidence: 99%

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Szydzik

Brazilek

Nesbitt

2020

Semin Thromb Hemost

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The manipulation of blood within in vitro environments presents a persistent challenge, due to the highly reactive nature of blood, and its multifaceted response to material contact, changes in environmental conditions, and stimulation during handling. Microfluidic Lab-on-Chip systems offer the promise of robust point-of-care diagnostic tools and sophisticated research platforms. The capacity for precise control of environmental and experimental conditions afforded by microfluidic technologies presents unique opportunities that are particularly relevant to research and clinical applications requiring the controlled manipulation of blood. A critical bottleneck impeding the translation of existing Lab-on-Chip technology from laboratory bench to the clinic is the ability to reliably handle relatively small blood samples without negatively impacting blood composition or function. This review explores design considerations critical to the development of microfluidic systems intended for use with whole blood from an engineering perspective. Material hemocompatibility is briefly explored, encompassing common microfluidic device materials, as well as surface modification strategies intended to improve hemocompatibility. Operational hemocompatibility, including shear-induced effects, temperature dependence, and gas interactions are explored, microfluidic sample preparation methodologies are introduced, as well as current techniques for on-chip manipulation of the whole blood. Finally, methods of assessing hemocompatibility are briefly introduced, with an emphasis on primary hemostasis and platelet function.

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“…It can easily be peeled off from molded substrate with minimal damage to the molded chip. This method have been applied for poly(methyl methacrylate) (PMMA) [13,14], poly-propylene (PP) [15,16], polystyrene (PS) [17][18][19][20], and COC [21]. The challenge of this method is the fidelity transfer of height cannot be as good as metal and polymer molds.…”

Section: Introductionmentioning

confidence: 99%

Study on soft hot embossing process for making microstructures in a cyclo-olefin polymeric (COP) film

Lee

Hsu²

2022

J. Micromech. Microeng.

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Thermoplastic polymers are the primary materials for fabricating commercial microfluidic devices. Despite many excellent properties, the low thermal conductivity is a common limiting factor in speeding up temperature-dependent biological processes, particularly for polymerase chain reactions. There is a need to develop a fabrication process to create thin-film microfluidic devices that can have a small thermal mass and a short microchannel-to-surface distance. This type of device requires the depth of micropatterns to be very close to the film thickness, which can encounter serious fractures during the demolding process. To overcome this challenge, we develop a soft hot embossing process to create micropatterns in a 188 µm thick cyclo-olefin polymeric (COP) film with a high embossing-depth to film-thickness ratio. The advantage of using a soft master is it can easily be peeled off from the molded film without causing a fracture from micropatterns. Polydimethylsiloxane (PDMS) is used as the soft silicone master, and four different 110 µm high micropatterns are studied, including ribs, grooves, and circular columns and cavities. PDMS masters for creating a 110 µm deep microchannel with different arrays of 70 µm deep microwells are also investigated. The heights of these one-layer and two-layer PDMS masters are 58.8% and 95.7% of the film thickness. Experimental findings show that less than 3% height variation can be achieved using a single-layer PDMS master with a low aspect ratio. For the two-layer micropatterns, it was found that a dense array with a smaller gap between microwells can have a better pattern transfer. In summary, this study demonstrates the feasibility of using a soft master to create deep or tall micropatterns in a COP film. The possibility of using a soft hot embossing process to create micropatterns for thin-film microfluidic devices is verified.

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Vacuum pouch microfluidic system and its application for thin-film micromixers

Abstract: Vacuum pouch microfluidic system: a new type of lab-on-a-chip device that uses an on-chip vacuum pouch to drive a thin-film micromixer with a wide operation range.

Cited by 13 publications

References 27 publications

Microelectromechanical Systems Based on Magnetic Polymer Films

Microelectromechanical Systems Based on Magnetic Polymer Films

A Review of Design Considerations for Hemocompatibility within Microfluidic Systems

Study on soft hot embossing process for making microstructures in a cyclo-olefin polymeric (COP) film

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