Vacuolized Lymphocytes in CNS Diseases with Special Reference to Amaurotic Familial Idiocy

Increased Lysolecithin in Serum Extracts of Lipidoses, Particularly of Tay-Sachs Patients

“…T h ree o f th e four T ay -S ach s p a tie n ts to w hich T able II refers (X X X V , X L V , L V II) M'ere in different stages of the disease. T he d u ra tio n in th e first was m ore th a n 4 years an d 4 m o n th s [7], in the second a b o u t 2 y e a rs, in th e th ird less th a n 6 m o n th s. T here was a c e rta in parallelism b etw een th e d u ra tio n of th e disease and th e am o u n t of lysolecithin co n tain ed in th e serum e x tra c ts m easured in m ultiples of th e no rm al scrum . Tw o different serum specim ens w ere tak en from case X L V a t an in te rv a l of one y ear.…”

Acid Phosphatase Activity in Lymphocytes from Patients with Spielmeyer-Vogt-Batten’s Syndrome

“…On the other hand, they demonstrated wide variations in the number of vacuolated lymphocytes in the patients from week to week, without any relation to the clinical condition. Spiegel-Adolf et al (14) performed some histochemical studies on smears. Oil-red 0 and Sudan Black stains gave to a certain extent similar results.…”