Vacuna de la tos ferina. Reemergencia de la enfermedad y nuevas estrategias de vacunación

Llop, F.A. Moraga; Campins-Martí, Magda

doi:10.1016/j.eimc.2015.02.001

Cited by 11 publications

(7 citation statements)

References 32 publications

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“…This is a similar pattern to that described for other communicable diseases, and requires greater focus on this disease and its control [6, 7, 9, 16]. Despite the periodicity of the disease we can see in other studies that the last epidemic wave of pertussis shows an increasing trend of the disease [6, 14, 17].…”

Section: Discussionsupporting

confidence: 75%

“…Proper vaccination status was defined as follows: people older than 2 years who had been given at least 4 vaccination doses; toddlers between 1 and 2 years of age who had been given at least 3 doses (proper primary vaccination), babies between 6 months and 1 year who had received at least 2 doses; babies between 3 and 6 months who had received at least 1 vaccination doses; all babies less than 3 months old [14]. The age groups used to analyse the vaccination variables were under 1 year old and under 6 years old.…”

Section: Methodsmentioning

confidence: 99%

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Does the economic recession influence the incidence of pertussis in a cosmopolitan European city?

et al. 2019

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BackgroundIn the last few years, pertussis has re-emerged worldwide. The aim of this article is to study how the incidence of the disease has evolved in Barcelona city over a 16-year period, and determine which factors are associated with the evolution of the disease. We discuss the causes of the observed changes considering different possibilities such as vaccination coverage, vaccine effectiveness, increased surveillance or the effect of the current economic recession.MethodsWe performed a cross-sectional, observational, population-based descriptive study using data for the 2000–2015 period from the notifiable diseases register maintained by Barcelona Public Health Agency. We used Poisson regression to compute adjusted odds ratios (aOR) and their corresponding 95% confidence intervals (CI).ResultsA total of 1791 cases were registered. The incidence of the disease increased throughout the city from 2011 onwards. While children under 1 year of age had the highest-incidence and were the most at risk (aOR = 27.18, CI:23.51–31.44), we found that the age of affected children was higher in the last years. Incidence proportion (PRR) was lower among foreign-born children than native children (PRR = 0.43 CI:0.32–0.58). In the whole-cell vaccine period (2000–2004), the percentage of cases under 1 year of age who received the vaccine was lower than in 2005–2015 when the acellular vaccine was used (p = 0.01), suggesting a lower efficacy of the acellular vaccine. However, vaccination coverage in children under 6 years remained high (~ 90%), and there were no significant year-to-year variations (p = 0.757). Moreover, there did not appear to be any significant restrictions in medical care. According to the index of disposable household income (DHI), pertussis incidence increased from 2011 onwards in all neighbourhoods and remained higher in those with lower DHI.ConclusionsThe noteworthy increase in pertussis incidence does not seem to be due to the economic recession, but to other factors here described.

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Section: Discussionsupporting

confidence: 75%

Section: Methodsmentioning

confidence: 99%

Does the economic recession influence the incidence of pertussis in a cosmopolitan European city?

et al. 2019

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“…En la actualidad las vacunas en uso son las hexavalentes, que dan una cobertura contra DTPa-HB-VPI-Hib, la otra es la pentavalente conformada de DTPa-VPI-Hib y la trivalente; DTPa. Esta última tiene una carga baja antigénica para el agente B. pertussis (Moraga & Campins, 2015).…”

Section: Tipos De Vacunasunclassified

La tosferina, enfermedad re-emergente en Honduras

Benitez

Calix

Euceda

et al. 2018

Innovare: Rev. Ciencia Tecnol.

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La Tosferina es una infección que afecta las vías respiratorias altas y es causado por un agente bacteriano que afecta exclusivamente a los seres humanos llamado Bordetella pertussis. El cuadro clínico ocurre en diferentes fases (catarral, paroxística y convalecencia). La similitud con otras patologías, la falta de conocimiento en personal de salud y de reconocimiento en la población general, dificulta la detección temprana de casos y conlleva a diagnosticarla tardíamente con el riesgo de complicaciones. Pese a que existe vacunación con altas coberturas, la tosferina ha reaparecido en la última década en Latinoamérica y Honduras, perjudicando a diferentes grupos etarios y mostrando una alta carga de morbilidad y de mortalidad en caso de no tener un tratamiento adecuado oportuno. Este artículo de revisión pretende proveer al sector salud con conocimiento actualizado sobre prevención, diagnóstico, tratamiento y recomendaciones para el manejo de brotes de tosferina. Se enfatiza la importancia de reforzar la vigilancia epidemiológica como herramienta de detección precoz de brotes

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“…Despite widespread pertussis primary immunization in childhood, the pathogen continues to circulate in the population and has even reemerged with increased incidence. The limited ability of vaccines to provide long-term immunity within vaccinated individuals is one of the reasons for this re-emergence [ 5 ]. Published data report that protection following vaccination wanes after 4–12 years.…”

Section: Introductionmentioning

confidence: 99%

Neonatal Pertussis, an Under-Recognized Health Burden and Rationale for Maternal Immunization: A Systematic Review of South and South-East Asian Countries

et al. 2019

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Pertussis is an under-recognized cause of neonatal morbidity and mortality. To review information on the epidemiology and disease burden of neonatal pertussis in South and Southeast Asian countries, a systematic literature review of three bibliographic databases was undertaken. Peer-reviewed original studies on neonatal pertussis epidemiology and burden published since 2000, with a geographical scope limited to South and Southeast Asian countries, were included. Data were systematically extracted based on parameters defined a priori. Our findings show that the burden of neonatal pertussis and its complications is substantial. An increase in the number of pertussis cases has been noted since early 2000, ranging from 61 to 92.9% in infants 0–3 months old. The most common symptoms an infant is likely to present with are cough with or without paroxysms, cyanosis, apnea, tachypnea, difficulty in breathing and leukocytosis. In addition, it can lead to hospitalization (length of stay: 5–7 days), complications (e.g., pneumonia, seizures) and mortality ranging from 5.6 to 14.7%. Other observations indicate that diagnosis is challenging because of non-specific clinical symptoms. Specifically, for obstetricians and gynecologists, the information available for making informed decisions on the prevention of neonatal pertussis is unreliable. Maternal immunization against pertussis during late stages of pregnancy has proven to be efficacious and well tolerated. A high burden of neonatal pertussis, as well as its complications, is observed in South and Southeast Asian countries. There is a need to intensify efforts to protect this vulnerable population with maternal vaccination. Funding : GlaxoSmithKline Biologicals SA Plain Language Summary : Plain language summary available for this article. Please see Fig. 1 and the following link: https://doi.org/10.6084/m9.figshare.7951187 .

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Vacuna de la tos ferina. Reemergencia de la enfermedad y nuevas estrategias de vacunación

Cited by 11 publications

References 32 publications

Does the economic recession influence the incidence of pertussis in a cosmopolitan European city?

Does the economic recession influence the incidence of pertussis in a cosmopolitan European city?

La tosferina, enfermedad re-emergente en Honduras

Neonatal Pertussis, an Under-Recognized Health Burden and Rationale for Maternal Immunization: A Systematic Review of South and South-East Asian Countries

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