Vacina contra a febre amarela: reações adversas e populações de risco

Egg allergy and yellow fever vaccination

“… 1 , 2 , 3 , 4 , 5 , 6 , 7 Patients with hen's egg allergy have restrictions on the use of some vaccines due to the possibility of adverse events after immunization (AEAI) resulting from the presence of hen's egg allergens in the vaccine, generated during the manufacturing process. 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 …”

“…: hen embryo cells). 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 Regarding hen's egg proteins, the maximum allowed and accepted concentration at 2μg/mL is established as safe for patients with a previous history of anaphylaxis to hen's egg. 8 …”

“…YFV is grown on embryonated hen eggs and since it is not heated during its production, it presents residual amounts of egg proteins. 8 , 9 , 10 , 11 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 This amount is variable according to the origin of the vaccine, often above what is allowed, and other times not informed by the manufacturer. 18 , 19 In Brazil, there are two types of YFV available, one produced by Biomanguinhos-Fiocruz and distributed by the public network, and another produced by Sanofi Pasteur (Stamaril®) which is used in the private network.…”

“… 18 , 19 In Brazil, there are two types of YFV available, one produced by Biomanguinhos-Fiocruz and distributed by the public network, and another produced by Sanofi Pasteur (Stamaril®) which is used in the private network. 14 The YFV produced by Biomanguinhos-Fiocruz has in its composition: live attenuated virus of 17DD substrain, derived from an African sample of wild YF virus, grown in hen embryo cells, and sucrose, sodium glutamate, sorbitol, hydrolyzed bovine gelatin, erythromycin, kanamycin as excipients. 25 The concentration of ovalbumin is not described in the package insert, however, levels of up to 4.42 µg/mL have been identified, depending on the manufacturing batch.…”

“…Due to the yellow fever epidemic, it was not possible to delay vaccination, and patients with a history of egg allergies were vaccinated after skin tests with YFV. 8 , 9 , 10 , 13 , 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 …”