1975
DOI: 10.1007/bf01317965
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Vaccinia virus variants as presumable cause of vaccinial complications

Abstract: Two vaccinia viruses isolated from patients with vaccinial complications (vaccinial ulcer, postvaccinial seizures) showed qualitative differences from the original parental strain. After intradermal injection of the viruses into the rabbit marked necroses developed, which the original strains did not produce. While the parental virus did not grow on the chorioallantoic membrane at 41 degrees C after 2 days incubation, the vaccinia variant produced typical lesions at that temperature. Also the yield of infectio… Show more

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Cited by 8 publications
(1 citation statement)
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“…However, there is reason to believe that a welldefined clonal product has advantages. Ehrengut et al 19,20 recovered vaccinia virus from patients who had dermatologic (vaccinia ulcer) or neurological complications. The viruses isolated from the affected patients differed from the parental vaccine in being resistant to high temperature, growing to higher titer in cell culture, producing larger plaque sizes, and causing marked necrosis in rabbit skin after intradermal inoculation.…”
Section: Discussionmentioning
confidence: 99%
“…However, there is reason to believe that a welldefined clonal product has advantages. Ehrengut et al 19,20 recovered vaccinia virus from patients who had dermatologic (vaccinia ulcer) or neurological complications. The viruses isolated from the affected patients differed from the parental vaccine in being resistant to high temperature, growing to higher titer in cell culture, producing larger plaque sizes, and causing marked necrosis in rabbit skin after intradermal inoculation.…”
Section: Discussionmentioning
confidence: 99%